Silica nanoparticles induce conformational changes of tau protein and oxidative stress and apoptosis in neuroblastoma cell line.

The adverse effects of SiO NPs on the biological systems like nervous system have not been well explored. This study aimed to evaluate the toxicity of SiO NPs on the nervous system in vitro. Therefore, human tau protein and neuroblastoma cell line (SH-SY5Y) were used as targets.