Self-assembly of bile salts and their mixed aggregates as building blocks for smart aggregates.

The present communication offers a comprehensive overview of the self-assembly of bile salts emphasizing their mixed smart aggregates with a variety of amphiphiles. Using an updated literature survey, we have explored the dissimilar interactions of bile salts with different types of surfactants, phospholipids, ionic liquids, drugs, and a variety of natural and synthetic polymers. While assembling this review, special attention was also provided to the potency of bile salts to alter the size/shape of aggregates formed by several amphiphiles to use these aggregates for solubility improvement of medicinally important compounds, active pharmaceutical ingredients, and also to develop their smart delivery vehicles.

Interaction, solubilization and location of p-hydroxybenzoic acid and its sodium salt in micelles of moderately hydrophilic PEO-PPO-PEO triblock copolymers.

Micelles of ABA type triblock copolymers (where A is polyethylene oxide PEO and B is polypropylene oxide PPO) viz. Pluronic® P103, P104 and P105 (each containing almost the same PPO mol wt. ~ 3250 g/mol and 30, 40 and 50 wt.