Alterations of Parenchymal Microstructure, Neuronal Connectivity, and Cerebrovascular Resistance at Adolescence after Mild-to-Moderate Traumatic Brain Injury in Early Development.

Traumatic brain injury (TBI) is a leading cause of morbidity in children. To investigate outcome of early developmental TBI during adolescence, a rat model of fluid percussion injury was developed, where previous work reported deficits in sensorimotor behavior and cortical blood flow at adolescence. Based on the nonlocalized outcome, we hypothesized that multiple neurophysiological components of brain function, namely neuronal connectivity, synapse/axonal microstructural integrity, and neurovascular function, are altered and magnetic resonance imaging (MRI) methods could be used to determine regional alterations.

Solid papillary carcinoma with reverse polarity of the breast harbors specific morphologic, immunohistochemical and molecular profile in comparison with other benign or malignant papillary lesions of the breast: a comparative study of 9 additional cases.

Solid papillary carcinoma with reverse polarity is a rare breast cancer of favorable prognosis that can be difficult to diagnose. We report here nine additional cases of this tumor, and we describe its morphologic, immunohistochemical and molecular profile in comparison to other types of papillary and micropapillary lesions of the breast that are intraductal papilloma with usual ductal hyperplasia, encapsulated papillary carcinoma, solid papillary carcinoma and invasive micropapillary carcinoma. We studied nine cases of this special papillary tumor and six of each other types mentioned above.

The first case of bacillus Calmette-Guérin-induced small-vessel central nervous system vasculitis.

To present an unrecognized vascular complication of bacillus Calmette-Guérin (BCG) therapy administered for superficial bladder carcinoma. We also review the potential mimickers for primary angiitis of the central nervous system (PACNS) as well as complications of intravesical BCG therapy. An 89-year-old Caucasian man with a history of relapsing high-grade bladder carcinoma treated with intravesical BCG presented with recurring episodes of right upper limb paresthesia with clumsiness and dysarthria.

Understanding the patient perspective on research access to national health records databases for conduct of randomized registry trials.

Background: Use of health administrative databases is proposed for screening and monitoring of participants in randomized registry trials. However, access to these databases raises privacy concerns. We assessed patient's preferences regarding use of personal information to link their research records with national health databases, as part of a hypothetical randomized registry trial.

Glutathione: Antioxidant Properties Dedicated to Nanotechnologies.

Which scientist has never heard of glutathione (GSH)? This well-known low-molecular-weight tripeptide is perhaps the most famous natural antioxidant. However, the interest in GSH should not be restricted to its redox properties. This multidisciplinary review aims to bring out some lesser-known aspects of GSH, for example, as an emerging tool in nanotechnologies to achieve targeted drug delivery.

Indications for and clinical procedures resulting from magnetic resonance imaging of the knee in older patients: Are we choosing wisely?

Objective: To analyze the indications for and clinical procedures resulting from knee magnetic resonance imaging (MRI) in older patients.

Design: We retrospectively analyzed 215 medical records of patients 50 years of age and older who had undergone a unilateral knee MRI in 2009.

Setting: Centre hospitalier universitaire de Sherbrooke in Quebec.

The Co-Occurrence of Asexuality and Self-Reported Post-Traumatic Stress Disorder Diagnosis and Sexual Trauma Within the Past 12 Months Among U.S. College Students.

An increasing number of individuals identify as asexual. It is important to understand the relationship between a diagnosis of post-traumatic stress disorder or a history of sexual trauma co-occurs with asexual identity. We aimed to assess whether identification as asexual was associated with greater likelihood for self-reported PTSD diagnosis and history of sexual trauma within the past 12 months.

Lung cancer and socioeconomic status in a pooled analysis of case-control studies.

Background: An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study.

Methods: Twelve case-control studies from Europe and Canada were included in the analysis.

What Is Bad From the Gander Is Bad From the Goose: Development and Validation of the Women's Objectification of Women Scale.

Existing measures of experiences of sexualization and objectification of women focus on behaviors that men do toward women. However, women may also contribute to the objectification of other women. The aim of the present study was to develop the Women's Objectification of Women Scale (WOWS).

Mental Help Seeking Attitudes Scale (MHSAS): Development, reliability, validity, and comparison with the ATSPPH-SF and IASMHS-PO.

Attitudes is a key help-seeking construct that influences treatment seeking behavior via intention to seek help, per the theory of planned behavior (TPB). This article presents the development and psychometric evaluation of the Mental Help Seeking Attitudes Scale (MHSAS), designed to measure respondents' overall evaluation (unfavorable vs. favorable) of their seeking help from a mental health professional.

Is Minority Stress in the Eye of the Beholder? A Test of Minority Stress Theory with Christians.

Studies using minority stress theory have focused on the experiences of numerical and social power minorities, though majority individuals may also perceive themselves to be minorities. We explored minority stress theory among a sample of members of a numerically and socially dominant group: Christians in the USA. Perceiving oneself to be a member of a minority as a Christian was associated with stress indirectly via perceived experiences of faith-based discrimination (i.

A Description of Patient and Provider Experience and Clinical Outcomes After Heart Failure Shared Medical Appointment.

Background: Shared medical appointments (SMAs) are clinical visits in which several patients meet with 1 or more providers at the same time.

Objective: To describe the outcomes of an interdisciplinary SMA for veterans recently discharged for heart failure (HF).

Methods: A retrospective chart review for patients' readmission rates, survival, medication adherence, and medication-related problems.

Men's Mental Health Help-Seeking Behaviors: An Intersectional Analysis.

Men seek mental health treatment less often than women. The present study sought to elucidate identities and individual difference characteristics that are associated with enhanced or decreased mental health help-seeking in a large national sample of U.S.

Changes in Outcomes of Cardiac Allograft Vasculopathy Over 30 Years Following Heart Transplantation.

Objectives: This study investigated temporal changes in the demographics and the prognosis of cardiac allograft vasculopathy (CAV) over 30 years following heart transplantation (HTx).

Background: Effects of the changing HTx demographics on CAV outcomes, based on International Society for Heart and Lung Transplantation (ISHLT) classification of CAV, have been incompletely investigated.

Methods: Patients who underwent HTx at the Montreal Heart Institute were classified according to the severity of CAV (CAV 0 is no presence of CAV; CAV 1 is mild, CAV 2 to 3 is moderate to severe) and era of HTx (early: 1983 to 1998; recent: 1999 to 2011).

Perceived Workplace Stress Is Associated with an Increased Risk of Prostate Cancer before Age 65.

Background: Evidence is lacking regarding the potential role of chronic psychological stress on cancer incidence. The workplace is reported to be the main source of stress among Canadian men. We examined the association between perceived lifetime workplace stress and prostate cancer (PCa) risk in a large case-control study.

Prostate cancer in firefighting and police work: a systematic review and meta-analysis of epidemiologic studies.

Objectives: We conducted a systematic review and meta-analysis to evaluate potential associations between firefighting and police occupations, and prostate cancer incidence and mortality.

Methods: Original epidemiological studies published from 1980 to 2017 were identified through PubMed and Web of Science. Studies were included if they contained specific job titles for ever/never firefighting and police work and associated prostate cancer risk estimates with 95% confidence intervals (CI).

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.

Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences.

Multimodal Imaging in Rat Model Recapitulates Alzheimer's Disease Biomarkers Abnormalities.

Imaging biomarkers are frequently proposed as endpoints for clinical trials targeting brain amyloidosis in Alzheimer's disease (AD); however, the specific impact of amyloid-β (Aβ) aggregation on biomarker abnormalities remains elusive in AD. Using the McGill-R-Thy1-APP transgenic rat as a model of selective Aβ pathology, we characterized the longitudinal progression of abnormalities in biomarkers commonly used in AD research. Middle-aged (9-11 months) transgenic animals (both male and female) displayed mild spatial memory impairments and disrupted cingulate network connectivity measured by resting-state fMRI, even in the absence of hypometabolism (measured with PET [F]FDG) or detectable fibrillary amyloidosis (measured with PET [F]NAV4694).

Eyes have ears: Indexing the orienting response to sound using pupillometry.

The rare occurrence of a sound deviating from the auditory background tends to trigger attentional orienting. While some sympathetic physiological responses can be used to index this orienting response, findings surrounding the pupillary dilation response (PDR) as a proxy for the orienting response are conflicting. The current study was tailor-designed to examine whether the PDR satisfies specific criteria of an orienting response index, namely the classic habituation pattern and a sensitivity to the size of the deviation.

The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other chemical agents.

Background: Little is known about occupational risk factors for meningioma.

Objectives: To study whether risk of meningioma is associated with several occupational exposures, including selected combustion products, dusts and other chemical agents.

Methods: The INTEROCC study was an international case-control study of brain cancer conducted in seven countries.

Occupational solvent exposure and risk of glioma in the INTEROCC study.

Background: The aetiology of glioma remains largely unknown. Occupational solvent exposure has been suggested as a putative cause of glioma, but past studies have been inconsistent. We examined the association between a range of solvents and glioma risk within the INTEROCC project, a study of brain tumours and occupational exposures based on data from seven national case-control studies conducted in the framework of the INTERPHONE study.

Lifetime occupational exposure to metals and welding fumes, and risk of glioma: a 7-country population-based case-control study.

Background: Brain tumor etiology is poorly understood. Based on their ability to pass through the blood-brain barrier, it has been hypothesized that exposure to metals may increase the risk of brain cancer. Results from the few epidemiological studies on this issue are limited and inconsistent.

Sexual orientation, bullying for being labeled gay or bisexual, and steroid use among US adolescent boys.

Use of anabolic-androgenic steroids is a public health concern for adolescent boys. This study examined bullying based on being labeled gay/bisexual and steroid use among US adolescent boys, including sexual orientation disparities. Data from 2660 boys from the 2015 Youth Behavior Risk Survey were used.