The relation of alcoholic myopathy to cardiomyopathy.

Objective: To evaluate the relation between skeletal muscle disease (myopathy) and degenerative changes in cardiac muscle (cardiomyopathy) in patients with chronic alcoholism.

Design: A cross-sectional study.

Setting: University medical center.

Left ventricular hypertrophy in asymptomatic essential hypertension: its relationship with aldosterone and the increase in sodium-proton exchanger activity.

In order to analyse the hormonal and erythrocyte ion transport systems in relation to left ventricular hypertrophy (LV) in essential hypertension, a prospective study of 50 consecutive hypertensive patients under 55 years of age and without prior antihypertensive therapy was performed. Twenty-seven normal subjects with no family history of hypertension served as controls. LV hypertrophy, as assessed by echocardiography, was present in 64% of the hypertensive patients.

Erythrocyte ion fluxes in essential hypertensive patients with left ventricular hypertrophy.

Background: Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity and mortality in essential hypertension (EH). Several hemodynamic and nonhemodynamic factors have been involved in the development of LVH in hypertension, including abnormalities in cellular ion mobilization.

Methods And Results: We measured different ion transport systems in erythrocytes from 50 patients with EH classified as having or not having LVH measured by M-mode echocardiography.

Effect of birthweight, total protein, serum IgG and packed cell volume on risk of neonatal diarrhea in calves on two California dairies.

The objective of the study was to determine if there was a relationship between hematological, immunological and physiological variables of newborn calves and risk of diarrhea during the neonatal period. Four hundred and seventeen heifer calves from two dairies (A and B) in the San Joaquin Valley of California were enrolled at birth and scored daily, to 28 days of age, for evidence and severity of diarrhea (0 to 3). Calves were weighted at birth and blood sampled at two to five days of age to determine packed cell volume (PCV), total protein (TP) and IgG serum concentration.

Isolation and structural characterization by spectroscopic methods of two glucuronide metabolites of mexiletine after N-oxidation and deamination.

Urine samples from control and mexiletine-treated human subjects or rabbits (test group) were collected and passed through an ion exchange resin to isolate polar compounds. Methanolic eluates from control and test urines were analyzed by TLC. Exposure to p-dimethylaminocinnamaldehyde gave an additional intense pink band at Rt 0.

[Preliminary data on dermatomycoses in Ouagadougou (Burkina Faso)].

This study is a contribution to a best knowledge of mycosis in Burkina Faso where the data concerning these diseases are very old. It has been focused on the clinical and mycological features of the dermoskeloton mycosis through the consultations at the two offices of dermatology in the city of Ouagadougou. From April to October, 1990, 216 patients have been taken census of, and they have shown 265 lesions among which 143 mycosis of the skinfolds (54 p.

[Serum myoglobin: evaluation of two immunolatex methods. Comparison with a radioimmunoassay method].

Latex immunoturbidimetric (ITA) and immunonephelemetric (INA) assays, were evaluated and compared to a radioimmunological assay (RIA) for the determination of serum myoglobin. Within-run and between-run assays and accuracy and linearity studies gave satisfactory results, very similar to those of RIA. Results were closely correlated with those of RIA for 100 samples of up to 2,000 micrograms/l (correlation coefficients respectively 0.

Severe ovarian hyperstimulation syndrome: role of peripheral vasodilation.

Objective: To investigate the pathogenesis of the systemic hemodynamic disturbance and the renal production of vasodilator prostaglandins (PGs) in the ovarian hyperstimulation syndrome.

Design: Prospective longitudinal study.

Setting: Assisted Reproduction Unit of the Hospital Clínic i Provincial in Barcelona.

[Acute fulminant myocarditis in a young man of 19].

We report the case of a 19-year-old male who developed an acute myocarditis, with restrictive hemodynamic pattern and cardiogenic shock, and who died 48 hours after hospital admission. We discuss the characteristics of this uncommon form of presentation of acute myocarditis, and the importance of early diagnosis and treatment.

Cardiac hemangioma with papillary endothelial hyperplasia: report of a resected case and review of the literature.

A case of left atrial hemangioma with papillary endothelial hyperplasia in a 42-year-old man is reported. With the aid of cardiopulmonary bypass, the tumor was resected, and the patient is well 22 months after operation. The clinical symptoms at initial examination, operative procedure, and pathological findings are reported, and the diagnostic and therapeutic approaches to cardiac tumors are described briefly.

[Infective endocarditis caused by coagulase-negative staphylococci: a review of 19 cases].

The clinical, microbiological and echocardiographical features as well as the response to therapy of 19 cases of infective endocarditis (IE) caused by coagulase-negative staphylococci (CNS) are reported. Six patients had native valve IE, 11 had prosthetic valve endocarditis and 2 were associated with catheters in right cardiac chambers. In the group of native valve IE, 11 patients were heroin abusers and 4 had previous valvular disease.

Mapping a gene for familial hypertrophic cardiomyopathy to chromosome 14q1.

To identify the chromosomal location of a gene responsible for familial hypertrophic cardiomyopathy, we used clinical and molecular genetic techniques to evaluate the members of a large kindred. Twenty surviving and 24 deceased family members had hypertrophic cardiomyopathy; 58 surviving members were unaffected. Genetic-linkage analyses were performed with polymorphic DNA loci dispersed throughout the entire genome, to identify a locus that was inherited with hypertrophic cardiomyopathy in family members.

[Myocardial infarction in a young woman with left atrial myxoma].

A 38 year old female patient without coronary risk factors suffered an acute myocardial infarction. Echocardiographic and cardiac catheterization was undertaken and a left atrial mass with normal coronary arteries was assessed. The tumor mass was successfully resected and pathological examination of the specimen disclosed a myxoma.

[Resection with removal of a primary fibrosarcoma of the left auricle. Value of two-dimensional echocardiography in the clinical diagnosis].

A primary fibrosarcoma was removed from the left atrium in a 58-year-old woman. We comment on the rareness of this cardiac neoplasm, the usefulness of two-dimensional echocardiogram in the clinical diagnosis of all cardiac tumors, and also the necessity for surgical treatment.

Long-term follow-up of drug abusers with intravenous talcosis.

Six patients who injected talc containing drugs intended for oral use were assessed over a period of ten or more years from the time of initiation of this habit. Despite discontinuation of the drug abuse, all developed severe respiratory disability and three died from their disease. An evolving spectrum of roentgenographic and functional patterns is considered to be virtually diagnostic of this disorder.

Characterization of digoxin and related cardiac glycosides by fast atom bombardment mass spectrometry.

The potential of using fast atom bombardment mass spectrometry for the detection and the characterization of digoxin and a series of related cardenolide analogues was investigated. The spectra were dependent upon the type of support-matrix in which they were recorded; thioglycerol proved to be satisfactory for the characterization of digoxin and allowed for its detection in human urine extract spiked with ca 11 ng ml(-1).

Systolic compression of coronary artery in hypertrophic cardiomyopathy.

To determine the prevalence and significance of the systolic compression of the anterior descending coronary artery in hypertrophic cardiomyopathy, we studied 54 consecutive patients out of a catheterization laboratory population of 1619. This angiographic finding was found to be more prevalent (P less than 0.001) and severe in myopathic than in secondary hypertrophy.