A Novel Device and Method for Assay of Bacterial Chemotaxis Towards Chemoattractants.

Capillary assemblies and microfluidic devices used for bacterial chemotaxis assays have certain inherent limitations. This opens opportunities for innovation in the area. The present study describes an innovative economical device called chemotaxis plate and also a method to use this device for chemotaxis assay.

Environmental implications and nanotechnological advances in octocrylene-enriched sunscreen formulations: A comprehensive review.

Ultraviolet (UV) radiation is a major contributor to skin aging, cancer, and other detrimental health effects. Sunscreens containing FDA-approved UV filters, like avobenzone, offer protection but suffer from photodegradation and potential phototoxicity. Encapsulation, antioxidants, and photostabilizers are strategies employed to combat these drawbacks.

Development of an Analytical Quality by Design RP-HPLC Method and Its Validation for Estimation of Gefitinib From Bulk, Tablet Dosage Form, and Complex Nanoformulation.

Background: Estimation of the drug and development of the method is a critical aspect of formulation development and a critical factor for analytical scientists. Gefitinib is a poorly soluble anticancer drug.

Objective: The present research focuses on the topic of the development of innovative quality by design methods for the estimation of gefitinib (GF) from bulk, pharmaceutical tablet formulation, and complex nanoformulations.

Integrated analytical hierarchy process-grey relational analysis approach for mechanical recycling scenarios of plastics waste in India.

Mechanical recycling is an indispensable tool for plastic waste (PW) recycling and has the highest share in the PW recycling sector in India. The transition to the circular economy of plastics (CEoP) needs a systemic perspective on the mechanical recycling processes. Nevertheless, the assessment of multiple parameters influencing the mechanical recycling of PW is a complex decision-making problem for the development of triple-bottom-line mechanical recycling.

The Nanotech Potential of Curcumin in Pharmaceuticals: An Overview.

It is safe to use Curcumin as a cosmetic and therapeutic ingredient in pharmaceutical products. For the uses mentioned above and for fundamental research, it is essential to obtain pure Curcumin from plant sources. There is a requirement for effective extraction and purification techniques that adhere to green chemistry standards for efficiency improvement, process safety, and environmental friendliness.

Comparison of Tool Wear, Surface Roughness, Cutting Forces, Tool Tip Temperature, and Chip Shape during Sustainable Turning of Bearing Steel.

In this study, a comparison of measured cutting parameters is discussed while machining AISI 52100 low-alloy hardened steel under two different sustainable cutting environments, those in which a dry and minimum quantity lubrication (MQL) medium are used. A two-level full factorial design method has been utilized to specify the effect of different experimental inputs on the turning trials. Experiments were carried out to investigate the effects of three basic defining parameters of turning operation which are namely cutting speed, cutting depth, feed rate effects and also the effects of the cutting environment.

Biofabrication of nanoparticles: sources, synthesis, and biomedical applications.

Nanotechnology is an emerging applied science delivering crucial human interventions. Biogenic nanoparticles produced from natural sources have received attraction in recent times due to their positive attributes in both health and the environment. It is possible to produce nanoparticles using various microorganisms, plants, and marine sources.

Drug Delivery Strategies for Avobenzone: A Case Study of Photostabilization.

Several developments and research methods are ongoing in drug technology and chemistry research to elicit effectiveness regarding the therapeutic activity of drugs along with photoprotection for their molecular integrity. The detrimental effect of UV light induces damaged cells and DNA, which leads to skin cancer and other phototoxic effects. The application of sunscreen shields to the skin is important, along with recommended UV filters.

Progress on Thin Film Freezing Technology for Dry Powder Inhalation Formulations.

The surface drying process is an important technology in the pharmaceutical, biomedical, and food industries. The final stage of formulation development (i.e.

Sulfobutylether-β-cyclodextrin: A functional biopolymer for drug delivery applications.

Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with many favorable properties viz. relatively high solubility (>50 folds compared to β-CD), improved stability, and biocompatibility that praised SBE-β-CD as a smart polymer for drug delivery applications.

Functional Thermoresponsive Hydrogel Molecule to Material Design for Biomedical Applications.

Temperature-induced, rapid changes in the viscosity and reproducible 3-D structure formation makes thermos-sensitive hydrogels an ideal delivery system to act as a cell scaffold or a drug reservoir. Moreover, the hydrogels' minimum invasiveness, high biocompatibility, and facile elimination from the body have gathered a lot of attention from researchers. This review article attempts to present a complete picture of the exhaustive arena, including the synthesis, mechanism, and biomedical applications of thermosensitive hydrogels.

Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based in situ gel for ocular delivery: In vitro, ex vivo, and toxicity assessment.

The research study reflects the development of novel voriconazole (VCZ) loaded nanoparticles (NPs) for prolonged delivery for the management of ocular diseases. The in situ ophthalmic gel was prepared by incorporating NPs into carboxymethyl chitosan (CMCh) and poloxamer. The central composite design was used to optimize the process for the preparation of nanoparticles by the o/w solvent evaporation method.

Advances in fabrication of molecularly imprinted electrochemical sensors for detection of contaminants and toxicants.

Worldwide growing concerns about water contamination and pollution have increased significant interest in trace level sensing of variety of contaminants. Thus, there is demand for fabrication of low cost, miniaturized sensing device for in-situ detection of contaminants from the complex environmental matrices capable of providing selective and sensitive detection. Molecularly imprinted polymers (MIPs) has portrayed a substantial potential for selective recognition of various toxicants from a variety of environmental matrices, thus widely used as artificial recognition element in the electrochemical sensors (ECS) owing to their chemical stability, easy and low cost synthesis.

Development of asolectin-based liposomal formulation for controlled and targeted delivery of erlotinib as a model drug for EGFR monotherapy.

The present investigation was envisaged to develop liposomal formulation for efficacious and targeted delivery of epidermal growth factor receptor (EGFR) inhibitor (erlotinib) against pancreatic cancer. The marketed formulations bearing current EGFR inhibitors exhibit serious adverse effects including severe skin, hemolytic and gastrointestinal toxicity. To address the obstacles, we have developed the liposomal formulation, by ether injection method, comprising erlotinib, a tyrosine kinase EGFR inhibitor, proposed to be targeted through enhanced permeability and retention effect (EPR) effect against pancreatic cancer.

Therapeutic implications of dermoscopic findings in acanthosis nigricans: A clinical and histopathological study.

Acanthosis nigricans is associated with numerous systemic disorders. These include endocrinological conditions such as, diabetes, acromegaly, Cushing's syndrome, thyroid dysfunction, as well as metabolic abnormalities like obesity and polycystic ovarian disease. Its association with visceral malignancy is known.

Mannose-anchored N,N,N-trimethyl chitosan nanoparticles for pulmonary administration of etofylline.

Drug delivery to lungs via pulmonary administration offers potential for the development of new drug delivery systems. Here we fabricated the etofylline (ETO) encapsulated mannose-anchored N,N,N-trimethyl chitosan nanoparticles (Mn-TMC NPs). The prominent characteristics like biocompatibility, controlled release, targeted delivery, high penetrability, enhanced physical stability, and scalability mark Mn-TMC NPs as a viable alternative to various nanoplatform technologies for effective drug delivery.

Effect of process parameters on the recovery of lactose in an antisolvent acetone/acetone-ethanol mixture: A comparative study based on sonication medium.

Recovery of lactose from the whey using sonocrystallization was studied experimentally. The effect of sonication medium and irradiation power levels was evaluated using three different ultrasonic equipments. Effects of various parameters such as sonication time, pH of the medium, antisolvent (acetone and acetone-ethanol mixture) and concentration of lactose were determined.

Bioactive supra decorated thiazolidine-4-carboxylic acid derivatives attenuate cellular oxidative stress by enhancing catalase activity.

A pharmacophoric motif decorated with supramolecular functionalities (TZT) was designed for potential interaction with biological targets. Main insights of this work include the correlation of supra functionalities of TZT with its binding ability to proteins leading to the modulation of their structure and bioactivity as a promising perspective in the field of cellular protection from oxidative stress. To investigate the role of TZT in obliterating oxidative stress at a molecular level, its binding propensity with bovine serum albumin (BSA) and bovine liver catalase (BLC) was characterized using various biophysical methods.

Electrochemical performance of a self-assembled two-dimensional heterostructure of rGO/MoS/h-BN.

We report the preparation and electrochemical performance evaluation of a two-dimensional (2D) self-assembled heterostructure of graphene oxide (rGO), molybdenum disulphide (MoS), and hexagonal boron nitride (h-BN). In the present study, the rGO-MoS-h-BN (GMH) multi-layered GMH heterostructure is fabricated an chemical route. Based on material analysis, the composite consists of bond conformations of C-B-C, Mo-S, C-N, B-N, and Mo-C, indicating the layered stacks of rGO/h-BN/MoS.

Ruthenium-decorated vanadium pentoxide for room temperature ammonia sensing.

Layer structured vanadium pentoxide (VO) microparticles were synthesized hydrothermally and successfully decorated by a facile wet chemical route, with ∼10-20 nm sized ruthenium nanoparticles. Both VO and ruthenium nanoparticle decorated VO (1%Ru@VO) were investigated for their suitability as resistive gas sensors. It was found that the 1%Ru@VO sample showed very high selectivity and sensitivity towards ammonia vapors.

Development of pH-Dependent Nanospheres for Nebulisation- In vitro Diffusion, Aerodynamic and Cytotoxicity Studies.

The aim of this work was to evaluate the in vitro performance of nebulized nanosuspension formulation when nebulized using ultrasonic nebulizer. The present investigation deals with successful formulation of Beclomethasone dipropionate loaded HPMCP nanospheres prepared by solvent evaporation technique using PEG 400 as a stabilizer. Beclomethasone dipropionate is a water insoluble drug molecule was encapsulated in HPMCP nanospheres to have pH dependent solubility at basic pH for targeted drug delivery in lung and studied for in vitro cytotoxicity and immediate release capability.