Publications by authors named "Paraskevi Georgiadis"
Article Synopsis
- - Disorders of sexual differentiation, like androgen insensitivity and gonadal dysgenesis, highlight a fluidity in gender that encompasses biological, anatomical, and social dimensions, influenced by societal norms.
- - George Engel's biopsychosocial model supports a flexible understanding of gender, which helps manage uncertainties in sex assignment and prepares for possible future changes.
- - It's essential for physicians to convey the biological aspects of gender fluidity to parents at diagnosis, educate them on potential hormone changes, and develop a clear sex-assignment algorithm as part of a good practice framework.
Background And Purpose: Germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) is the most common neurological problem of premature infants and has enormous financial and social impact. Despite this, there is no standardized animal model of IVH depicting acute brain injuries.
Methods: We delivered rabbit-pups prematurely at 29-day gestation by C-section, administered intraperitoneal glycerol to the pups at 3-hour postnatal age to induce IVH, and evaluated the brain for evidence of injuries.
Pelizaeus Merzbacher disease is an X-linked dysmyelinating disorder of the CNS, resulting from mutations in the proteolipid protein (PLP) gene. An animal model for this disorder, the myelin-deficient (MD) rat, carries a point mutation in the PLP gene and exhibits a phenotype similar to the fatal, connatal disease, including extensive dysmyelination, tremors, ataxia, and death at approximately postnatal day 21 (P21). We postulated that early death might result from disruption of myelinated neural pathways in the caudal brainstem and altered ventilatory response to oxygen deprivation or hypercapnic stimulus.
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