Publications by authors named "Paraskevas Lyberis"

Article Synopsis
  • Radical surgery is the most effective treatment for early-stage lung cancer, with video-assisted thoracic surgery (VATS) being a less painful alternative to traditional surgery methods.
  • Current localization techniques for identifying lung cancer are limited, particularly the near-infrared (NIR) indocyanine green (ICG) method, which struggles with deep tissue and lymph node detection.
  • This study tests the effectiveness of Cetuximab-IRDye800CW, a combination of a monoclonal antibody and an advanced NIR dye, in accurately marking lung nodules and lymph nodes during VATS for improved detection outcomes.
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  • A large multicenter study across 15 Italian hospitals evaluated the early and long-term outcomes of robot-assisted thoracoscopic thymectomy for thymic epithelial tumors, enrolling 669 patients from 2002 to 2022.
  • The study found that most patients (98%) underwent complete thymectomy with a low incidence of open conversion (3.4%) and no perioperative mortality; however, 7.7% experienced postoperative complications.
  • Results showed effective oncological outcomes with only 2 patients dying from tumor-related causes during follow-up, and the 5- and 10-year recurrence rates were low at 7.4% and 8.3%, respectively, indicating the procedure's safety and effectiveness.
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Article Synopsis
  • The study looked at patients with a type of cancer called thymoma who had it come back after treatment and underwent surgery.
  • They reviewed data from 40 patients and found that most had relapses in the chest or lungs, and some received extra treatments after surgery.
  • The results showed that patients with less aggressive cancer types had a higher chance of surviving longer, especially when they got additional treatment.
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  • The study investigates the impact of the number of involved structures (NIS) on the prognosis of patients with thymic epithelial tumors (TETs) who underwent surgery, using data from the European Society of Thoracic Surgeons (ESTS) thymic database.
  • Out of 303 patients analyzed, those with more than two involved structures had significantly worse cancer-specific survival (CSS) compared to those with two or fewer, with 5-year CSS rates of 9.5% versus 93.2%, respectively.
  • Factors such as neoadjuvant therapy, complete resection, and thymoma histology were associated with better prognosis, highlighting the importance of NIS in determining patient outcomes.
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Article Synopsis
  • - Robotic-assisted thoracic surgery (RATS) is gaining popularity among surgeons in Europe, but access and training vary significantly; 22% of surveyed centers had no robots, while 31% had limited access, highlighting disparities in availability.
  • - A survey of 174 thoracic surgeons indicated that most centers primarily use video-assisted thoracic surgery (VATS) over RATS, with many respondents believing VATS training aids robotic preparation; however, over half reported that robotic surgery training isn't part of their curriculum.
  • - Despite variations in approach, many surgeons (71%) agree future thoracic surgeons should be skilled in both VATS and RATS, noting that RATS may offer advantages like improved lymph node harvesting, although
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Article Synopsis
  • The study investigates the differences in perioperative outcomes between video-assisted thoracic surgery (VATS) and open lobectomy in obese patients undergoing surgery for non-small-cell lung cancer.
  • It analyzes data from 13,999 obese patients, revealing that VATS results in lower rates of complications, mortality, and shorter hospital stays compared to traditional thoracotomy.
  • The findings suggest that VATS should be the preferred surgical method for obese patients, as it leads to better postoperative outcomes.
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Background: Radical resection of isolated lung metastases (LM) from colorectal cancer (CRC) is debated. Like Fong's criteria in liver metastases, our study was meant to assign a clinical prognostic score in patients with LM from CRC, aiming for better surgery selection.

Methods: We retrospectively analyzed data from 260 CRC patients who underwent curative LM resection from December 2002 to January 2022, verifying the impact of different clinicopathological features on the overall survival (OS).

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Background: The prognostic difference among patients affected by NSCLC with hilar metastases only or mediastinal nodes metastases without hilar involvement (skip metastases) is still unclear. Aim of this study is to analyse if prognostic difference are present or if the two groups present the same survival outcome.

Materials And Methods: Data on NSCLC patients from 7 high volume centres (2004-2014) were collected and retrospectively reviewed.

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Background: According to current guidelines, a surgical biopsy is rarely required when a high-confidence radiologic interstitial lung disease (ILD) diagnosis is made on thin-section high-resolution computed tomography (HRCT). Nevertheless, disowning HRCT scans diagnosed by biopsy are more common than presumed. Our study aimed to describe the concordance rate between HRCT scans and pathological diagnoses of ILDs obtained by surgical biopsy.

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Background: The aim of the study was to compare the effect on perioperative outcome of intraoperative use of different devices for tissue dissection (electrocoagulation [EC] or energy devices [ED]) in patients who underwent video-assisted thoracoscopic surgery (VATS) lobectomy for lung cancer.

Methods: We retrospectively reviewed 191 consecutive patients who underwent VATS lobectomy, divided into two cohorts: ED (117 patients), and EC (74 patients); after propensity score matching, 148 patients were extracted, 74 for each cohort. The primary endpoints considered were complication rate and 30-day mortality rate.

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Background: Tracheal stenosis and tracheo-esophageal fistulas are serious but rare complications of prolonged invasive mechanical ventilation. Tracheal resection with end-to-end anastomosis and endoscopic procedure are the options of care in the treatment of tracheal injuries. Tracheal stenosis could be iatrogenic, associated with tracheal tumors, or idiopathic.

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Background: The minimally invasive management of sub-centimetric and often sub-solid lung lesions is quite challenging for thoracic surgeons. As a matter of fact, thoracoscopic wedge resection can often require conversion to thoracotomy when pulmonary lesions cannot be visually identified. Hybrid operating rooms (ORs) can serve as a helpful tool in a multidisciplinary setting, providing real-time lesion imaging and targeting, allowing preoperative or intraoperative percutaneous placement of different lesions targeting techniques to help locate non-palpable lung nodules during video-assisted thoracic surgery.

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Introduction: Brachial plexus traumatic lesions often lead to severe upper extremity deficits that dramatically compromise quality of life of mostly young patients. Optimal treatment aims to restore elbow flexion transferring various donor nerves. Phrenic nerve (PN) is a powerful source of transferable axons and, despite supraclavicular sectioning being the most used technique, it can be harvested through video-assisted thoracoscopic surgery (VATS).

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Background: Since December 2019, Sars-CoV2 infection has become a pandemic health emergency. The most severe manifestation of COVID-19 is acute respiratory distress syndrome requiring intensive care unit admission and mechanical ventilation. The most serious, although rare, complication of prolonged MV is post-intubation tracheal stenosis.

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Unlabelled: Non-intubated thoracic surgery (NITS) is a growing practice, alongside minimally invasive thoracic surgery. To date, only a consensus of experts provided opinions on NITS leaving a number of questions unresolved. We then conducted a scoping review to clarify the state of the art regarding NITS.

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Precise diagnosis in intrathoracic malignancies is paramount for adequate treatment planning. Standard approach is histologic analysis from targeted biopsy obtained with different invasive procedures. Rarely, in difficult clinical scenarios, even gold standard diagnostic procedures can be ineffective in obtaining a satisfying result.

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Background: Several peripheral regional anaesthesia (RA) techniques are commonly used in thoracic surgery even in the absence of precise indications regarding their effectiveness on postoperative pain management.

Objective: This systematic review and meta-analysis aims to describe and evaluate the relative effectiveness of different peripheral regional blocks and systemic analgesia in the context of video-assisted thoracoscopic surgery (VATS) or thoracotomy.

Design: Systematic review of randomized controlled clinical trials (RCTs) with meta-analyses.

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Background: According to the international guidelines, patients affected by interstitial lung disease with unusual clinical presentation and radiological findings that are not classic for usual interstitial pneumonia end up meeting criteria for surgical lung biopsy, preferably performed with video-assisted thoracic surgery. The growing appeal of non-intubated thoracic surgery has shown the benefits in several different procedures, but the strict selection criteria of candidates are often considered a limitation to this approach. Although several authors define obesity as a contraindication for non-intubated thoracoscopic surgery, the assessment of obesity as a dominant risk factor represents a topic of debate when minor tubeless procedures such as lung biopsy are considered.

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Background: Only a small number of studies have explored the clinicopathological features of pulmonary adenocarcinoma (PA) associated with F-fluorodeoxyglucose positron emission tomography (FDG-PET) false-negative (FN) results. Herein, we investigated the FDG-PET diagnostic performance by stratifying PAs according to International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification.

Methods: From January 2002 to December 2016, all consecutive patients who underwent pulmonary resection for stage I PA at six thoracic surgery institutions were retrospectively reviewed.

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Objectives: Obesity in Europe, and worldwide, has been an increasing epidemic during the past decades. Moreover, obesity has important implications regarding technical issues and the risks associated with surgical interventions. Nevertheless, there is a lack of evidence assessing the influence of obesity on video-assisted thoracic surgery (VATS) lobectomy results.

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Background: Risks associated with video-assisted surgical lung biopsy (VASLB) for interstitial lung disease (ILD) with endotracheal intubation and mechanical ventilation are not nil. Awake video-assisted surgical lung biopsy (Awake-VASLB) has been proposed as a method to obtain a precise diagnosis in several different thoracic diseases.

Objectives: To compare clinical outcomes of Awake-VASLB and Intubated-VASLB in patients with suspected ILDs.

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