Publications by authors named "Parasher G"

Article Synopsis
  • The study examined adverse events related to OVESCO® clips and cutters, focusing on data from the FDA's MAUDE database, covering reports from 2007 to 2024.
  • Out of 42 reports, the majority were about OVESCO® clips, with the most common issues being failure to deploy and gastrointestinal perforation as a significant complication.
  • The findings emphasize the importance of careful patient selection and monitoring after procedures, as well as the need for ongoing surveillance to ensure device safety and improve patient outcomes.
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Purpose: Family physician (FP)-performed screening colonoscopies can serve as 1 strategy in the multifaceted strategy necessary to improve national colorectal cancer screening rates, particularly in rural areas where specialist models can fail. However, little research exists on the performance of this strategy in the real world. In this study, we evaluated trends in and factors associated with FP-performed screening colonoscopies in the United States between 2016 and 2021.

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Muscular tuberculosis as a primary focal lesion in an immunocompetent individual without any underlying bone involvement is a rare finding. The authors present a case of a young female in her 30s who presented with complaints of recurrent discharging sinus in the posteromedial aspect of the proximal right thigh for eight months. The patient was treated by surgical debridement followed by antitubercular therapy (ATT) and has shown full recovery during the post-eight-month treatment period.

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Background Mastalgia often impairs the physical, social, and sexual lives of women. It may manifest in both cyclical or acyclical patterns. The psychoneurotic association of mastalgia has been claimed for a long time in various available literature.

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The anaerobic region of the gastrointestinal (GI) tract has been replicated in the anaerobic chamber of a microbial fuel cell (MFC). Electroactive biomolecules released by the facultative anaerobes (Providencia rettgeri) under anoxic conditions have been studied for their potential role for redox balance. MALDI study reveals the presence of vitamin B9 (folate), 6-methylpterin, para-aminobenzoic acid (PABA) and pteroic acid called pterin pool.

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Article Synopsis
  • A study evaluated the sessile serrated lesion detection rate (SSLDR) at a large medical center from 2008 to 2020 and suggested a target SSLDR goal.
  • Data from screening colonoscopies was analyzed, showing an increase in SSLDR from 0.37% in 2008 to 7.94% in 2020, indicating improved detection over time.
  • Among gastroenterology fellows, SSL detection significantly improved from their first to second year, but there was no significant change from their second to third year, highlighting ongoing variations in performance among endoscopists.
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  • Survival rates for colorectal cancer (CRC) have improved since 1975 in the US, but specific trends based on cancer stage among different racial and ethnic groups are not well understood.
  • A study using the SEER database from 1992-2018 analyzed 1- and 5-year CRC survival rates among various racial/ethnic subgroups, revealing significant differences in survival outcomes, particularly at the distant stage.
  • While overall survival has improved, American Indian/Alaska Native (AIAN) and non-Hispanic Black (NHB) individuals show the lowest survival probabilities, indicating a need for targeted research on mortality causes in CRC related to race and ethnicity.
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 Optical coherence tomography (OCT) is a new technology available for evaluation of indeterminate biliary strictures. It allows under-the-surface visualization and preliminary studies have confirmed standardized characteristics associated with malignancy. The aim of this study is to evaluate the first interobserver agreement in identifying previously agreed upon OCT criteria and diagnosing of malignant versus benign disease.

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Objectives: Studies of race-specific colon cancer (CC) survival differences between right- vs. left-sided CC typically focus on Black and White persons and often consider all CC stages as one group. To more completely examine potential racial and ethnic disparities in side- and stage-specific survival, we evaluated 5-year CC cause-specific survival probabilities for five racial/ethnic groups by anatomic site (right or left colon) and stage (local, regional, distant).

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Esophageal pathologies encountered on fluoroscopic examination may pose a diagnostic challenge to the interpreting Radiologist. Understanding the varied imaging appearances of esophageal pathology requires a thorough understanding of barium esophagography. This article reviews the various fluoroscopic imaging findings of different esophageal pathologies by describing an approach to image interpretation centered on dots, lines, contours, and ends.

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Artificial intelligence (AI) is a combination of different technologies that enable machines to sense, comprehend, and learn with human-like levels of intelligence. AI technology will eventually enhance human capability, provide machines genuine autonomy, and reduce errors, and increase productivity and efficiency. AI seems promising, and the field is full of invention, novel applications; however, the limitation of machine learning suggests a cautious optimism as the right strategy.

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Iatrogenic perforation is a known and feared complication of diagnostic and therapeutic colonoscopy. Specific locations in the gastrointestinal tract, such as the jejunum, have a higher risk of perforation owing to its difficult anatomical position. Over-the-scope clips have recently been used for the management of these perforations.

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Article Synopsis
  • Pancreatic Ductal Adenocarcinoma (PDAC) is highly lethal, difficult to diagnose early, and resistant to standard treatments, contributing to a low five-year survival rate.
  • Addressing these challenges requires a multidisciplinary strategy to enhance diagnosis, prognosis, and therapy for PDAC.
  • The use of quantitative tools, like mathematical modeling, has potential in understanding the disease, identifying early diagnostic biomarkers, and creating individualized treatment plans, though their application in PDAC has been limited so far.
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Pancreatic cancer is one of the most aggressive malignancies, accounting for more than 45,750 deaths annually in the U.S. alone.

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Background And Objectives: We present a multicenter study of a new endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) needle (Acquire, Boston Scientific, Natick, MA). The aim of the study was to analyze the needle's clinical performance when sampling solid lesions and to assess the safety of this device.

Methods: We performed a multicenter retrospective study of patients undergoing EUS-FNB during July 1-November 15, 2016.

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Iatrogenic duodenal injury occurring during laparoscopic cholecystectomy (LC) is managed surgically, though rarely a large, persistent fistula is refractory to surgical interventions. We present the case of a 40-year-old woman transferred to our centre following elective LC for a reported perforated duodenal ulcer. An uncontained leak was found to originate from a 1.

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Article Synopsis
  • - Eosinophilic gastroenteritis (EOGE) is a rare inflammatory disease affecting the stomach and intestines, primarily marked by a significant presence of eosinophils; this study aimed to explore its epidemiology, clinical traits, and patient outcomes in a specialized hospital over a ten-year period.
  • - A total of 13 EOGE cases were identified from 361 patient charts reviewed, with a majority being women; common symptoms included abdominal pain (62%), diarrhea (31%), and nausea/vomiting (31%); notable associations with atopy and food allergies were observed in several patients.
  • - Most patients showed eosinophilia, particularly those with ascites, and the follow-up revealed that 30%
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