Stem cell therapy for COVID-19 treatment: an umbrella review.

Background: COVID-19 has presented significant obstacles to healthcare. Stem cell therapy, particularly mesenchymal stem cells, has emerged as a potential treatment modality due to its immunomodulatory and regenerative properties. This umbrella review aims to synthesize current evidence from systematic reviews on the safety and efficacy of stem cell therapy in COVID-19 treatment.

Deciphering the Involvement of Chronic Inflammation in Osteoarthritis: Evaluation of Complement 3 and Cathepsin D in Osteoarthritic Patients-A Retrospective Case Study.

Background And Aim: Osteoarthritis (OA) stands as the prevailing degenerative joint condition, and although it is widely observed, its precise causes are not fully understood. The main focus of the study was to assess the role of Complement C3 and Cathepsin D in the development of knee osteoarthritis (OA), which is the most prevalent degenerative joint disease.

Materials And Methods: The study was carried out in 20 patients with knee OA and 20 healthy control group.

Retrospective Case Study on the Evaluation of Inflammatory Markers, Macrophage Inhibitory Protein-1α and Interferon-γ in Sleep Deprivation Condition.

Background And Aim: Sleep is an important physiological process that is necessary for the normal functioning of the body. Sleep greatly affects all aspects of our body, including the immune pathways or immune response system of our body, which plays a determinant role in the development and progression of chronic inflammatory diseases. In this study, we worked to find the relation between sleep deprivation and levels of pro-inflammatory markers macrophage inflammatory protein 1-alpha (MIP-1α) and interferon gamma (IFN-γ).

Computational exploration of FOXM1 inhibitors for glioblastoma: an integrated virtual screening and molecular dynamics simulation study.

In this study, a comprehensive investigation of a set of phytochemicals to identify potential inhibitors for the Forkhead box protein M1 (FOXM1) was conducted. FOXM1 is overexpressed in glioblastoma (GBM) cells and plays a crucial role in cell cycle progression, proliferation, and invasion. FOXM1 inhibitors have shown promising results in preclinical studies, and ongoing clinical trials are assessing their efficacy in GBM patients.

Green Synthesis, Characterization and Bioactivity of Seed-Wrapped Zinc Oxide Nanoparticles.

In the realm of nanoparticles, metal-based nanoparticles have traditionally been regarded as the pioneering category. Compared to other nanoparticles, zinc oxide nanoparticles have several advantages, including optical and biological properties, which provide them a significant competitive advantage in clinical and biological applications. In the current investigation, we used an aqueous seed extract to synthesize nanoparticles of zinc oxide (ZnO NPs).

Microalgae as a potential therapeutic drug candidate for neurodegenerative diseases.

Microalgae are highly photosynthetic unicellular organism that have increased demand in the recent days owing to the presence of valuable cellular metabolites. They are ubiquitous in terrestrial and aquatic habitats, rich in species diversity and are capable of generating significant biomass by efficiently using CO, light and other nutrients like nitrogen, phosphate etc., The microalgal biomass has upsurged in economic potential and is used as both food and feed in many countries across the world, accounting for more than 75 % of annual microalgal biomass production in the past decades.

Degradation of Toxic Dye and Antimicrobial and Free Radical Potential of Environmental Benign Zinc Oxide Nanoparticles.

Several industries have become major contributors to waterbody contamination due to the improper removal of dyes and effluents into water bodies. Due to their carcinogenic properties and low biodegradability, dye degradation is a considerable danger to people, animals, and the oceanic environment. As part of this study, leaf extract was used as a reducing and stabilizing agent to synthesize zinc nanoparticles and degrade dyes such as methyl red and eosin.

Apoptotic and Antioxidant Activity of Gold Nanoparticles Synthesized Using Marine Brown Seaweed: An In Vitro Study.

A major paradigm shift in the field of nanobiotechnology is the invention of an eco-friendly, economical, and green approach for synthesis of metal nanoparticles. In the present study, we have synthesized gold nanoparticles (AuNPs) using aqueous extracts of marine brown seaweed Sargassum longifolium. The synthesized nanoparticle was subjected to characterization using different techniques such as UV-Vis spectroscopy, Fourier transform infrared spectroscopy, atomic force microscope, scanning electron microscope, transmission electron microscope, and elemental dispersive X-ray diffraction.

Green synthesis, characterization and biological activity of -mediated silver nanoparticles.

Biologically inspired synthesis of nanoparticles was found to be more attractive in metal nanoparticle synthesis. The present study reported an biogenic synthesis of silver nanoparticles (AgNPs) using aqueous leaf extract. On this basis, the aqueous leaf extract of acted as a reducing agent and stabilizing agent to synthesize highly stable AgNPs at ambient temperature.

Role of Nanoparticles in Environmental Remediation: An Insight into Heavy Metal Pollution from Dentistry.

Environmental damage is without a doubt one of the most serious issues confronting society today. As dental professionals, we must recognize that some of the procedures and techniques we have been using may pose environmental risks. The usage and discharge of heavy metals from dental set-ups pollute the environment and pose a serious threat to the ecosystem.

Retraction Notice: Tocotrienols and its Role in Cardiovascular Health- a Lead for Drug Design.

The article has been retracted by the Editorial office of the journal Current Pharmaceutical Design, due to some inconsistencies in the article [1]. The article appeared to be copied verbatim from published papers. Upon checking these facts, we have established that considerable portions of this review are made up of text copied verbatim from other published material.

Improvements in morphology and membrane stability obtained from -, a cryopreservation medium treated infertile smoker sperm cells - An study.

Background: Plants are the major sources of antioxidants, which maintains oxidant: antioxidant state or is to protect from excessive reactive oxygen species in case of cryo medium selection though maintain sperm stability.

Bottleneck: Cryo preservation of infertile smokers is challengeable with the available medium due to over production of ROS hitches, were cause loss of sperm physiology. Hence, a novel medium is needed to store/protect sperm cells of infertile smokers where they attending/ongoing IVF or oncogenic surgical treatment.

Optimization of Human Semen Extender Components for Cryopreservation Using Statistical Tools.

Unlabelled: 　　BACKGROUND: Human sperm cell preservation is an important part of assisted reproductive technology (ART).

Objective: This study aimed to find the essential and significant components in semen preservation extender required to prolong the shelf life of human spermatozoa.

Materials And Methods: By using the statistical tool 'Plackett-Burman design' the significant components present in E4 extender (formulated in our previous study) was determined by reducing the unacceptable large number of trial experiments from the full factorial method.

Human sperm DNA damage inhibition and antioxidant activity of T. arjuna bark: an in vitro study.

Complimentary or natural antioxidant type of alternative medicine is developed worldwide to treat male infertility. The aim of this study is to the extraction of T. arjuna bark and activity against human sperm DNA damage in asthenoteratospermic smoker's subjects-an in vitro study.

Tea polyphenol-T. arjuna bark as sperm antioxidant extender in infertile smokers.

Background: Antioxidants protect spermatozoa against lipid peroxidation during freezing.

Objective: The study is designed to elucidate the suitable extender to preserve infertile semen of smokers against ROS damage using natural Tea polyphenol (T. arjuna bark extract).

Novel mononuclear Cu (II) terpyridine complexes: Impact of fused ring thiophene and thiazole head groups towards DNA/BSA interaction, cleavage and antiproliferative activity on HepG2 and triple negative CAL-51 cell line.

Two mononuclear copper (II) terpyridine complexes namely, [Cu(Btptpy) (ClO)](ClO) 1, and [Cu(Bttpy) (ClO)](ClO) 2, (Btptpy (L) = 4'-(Benzothiophene)-2,2':6',2″-terpyridine, Bttpy (L) = 4'-(Benzylthiazolyl)-2,2':6',2″-terpyridine) have been synthesized and characterized. Single crystal X-ray diffraction shows that, both ligands belong to monoclinic crystal system with space group P2/c (L) and P2/n (L). Absorption spectral titration, DNA melting study, circular dichroism and viscosity measurement reveal that, complex 1 and 2 bind with DNA through intercalation.

Validation of artificial neural network models for predicting biochemical markers associated with male infertility.

Unlabelled: Seminal fluid is the secretion from many glands comprised of several organic and inorganic compounds including free amino acids, proteins, fructose, glucosidase, zinc, and other scavenging elements like Mg(2+), Ca(2+), K(+), and Na(+). Therefore, in the view of development of novel approaches and proper diagnosis to male infertility, overall understanding of the biochemical and molecular composition and its role in regulation of sperm quality is highly desirable. Perhaps this can be achieved through artificial intelligence.

EFFECT OF SEMEN EXTENDER ON PROTEIN CONCENTRATION IN EACH FRACTION OF CRYOPRESERVED HUMAN SEMEN.

Background: Semen extender is liquid diluents which are added to semen to preserve its fertilizing ability. The addition of extender to semen protects the sperm against possible damage by toxic seminal plasma, as well as providing nutrients.

Aim And Objective: The hypotheses of the study are to evaluate, if there is any significant change in the protein concentration in each fractions of human semen before and after freezing with prepared semen extender.

Screening, production, optimization and characterization of β-glucosidase using microbes from shellfish waste.

An extracellular β-glucosidase was isolated from Proteus mirabilis VIT117 found to be growing on prawn shells. The enzyme production was found to be enhanced (14.58 U/ml) when the culture was maintained at pH 9 and provided with sorbitol as carbon source, yeast extract as nitrogen source and incubated at 37 °C for approximately 72 h.

DNA/protein interaction and cytotoxic activity of imidazole terpyridine derived Cu(II)/Zn(II) metal complexes.

Two imidazole terpyridine (itpy) based complexes, [Cu(itpy)(OAc)(H2O)]NO3·H2O (1) and [Zn(itpy)(OAc)]OAc (2) have been synthesised and characterized. The crystal structure of complex 1 shows distorted octahedral geometry with an anti-parallel stacking arrangement. The interactions of the two complexes with Calf thymus DNA (ctDNA) have been studied using absorption titration and circular dichroism.

Computational discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of Pseudomonas aeruginosa.

Drugs have been discovered in the past mainly either by identification of active components from traditional remedies or by unpredicted discovery. A key motivation for the study of structure based virtual screening is the exploitation of such information to design targeted drugs. In this study, structure based virtual screening was used in search for putative quorum sensing inhibitors (QSI) of Pseudomonas aeruginosa.

Methods to determine antipathogenic potential of phenolic and flavonoid compounds against urinary pathogen Serratia marcescens.

This study revealed the antipathogenic potential of natural compounds present in the edible fruits against urinary pathogen Serratia marcescens by using quorum sensing inhibition (QSI). The serum resistance assay was adopted to examine the immunomodulatory effects of QSI compounds to fight against bacterial infections.

Dynamic action of carotenoids in cardioprotection and maintenance of cardiac health.

Oxidative stress has been considered universally and undeniably implicated in the pathogenesis of all major diseases, including those of the cardiovascular system. Oxidative stress activate transcriptional messengers, such as nuclear factor-κB, tangibly contributing to endothelial dysfunction, the initiation and progression of atherosclerosis, irreversible damage after ischemic reperfusion, and even arrhythmia, such as atrial fibrillation. Evidence is rapidly accumulating to support the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as intracellular signaling molecules.

Health benefits of wine and alcohol from neuroprotection to heart health.

Controversy is common during efforts to define the role of nutrition in health, but few modern reflections of such controversy are as vivid as the debate over wine. There exists no query that chronic alcohol abuse, a leading worldwide problem, causes neuronal dysfunction and brain damage. However, various epidemiologic studies in recent years have indicated that in comparisons with abstainers or never drinkers, light/moderate alcohol/wine consumers have lower risks of age-dependent cognitive decline and/or dementia, including Alzheimer's disease (AD) Neurodegenerative diseases such as AD and Parkinson's (PD) diseases are defined by a progressive neuronal dysfunction and an ensuing behavioral dysfunction.

Indian spices for healthy heart - an overview.

Spices were some of the most valuable items of trade in the ancient and medieval world. Herbalist and folk practitioners have used plant remedies for centuries, but only recently have scientist begun to study the powers of common herbs and spices. In the current set-up, the anti-proliferative, anti-hypercholesterolemic, anti-diabetic, anti-inflammatory effects of spices have overriding importance, as the key health concern of mankind nowadays is diabetes, cardio-vascular diseases, arthritis and cancer.