Safety and Tolerability of Interval Compressed Chemotherapy Schedule in Children Receiving Treatment for Ewing Sarcoma: A Real-world Experience From India.

Background And Aims: Chemotherapy with alternating cycles of vincristine-doxorubicin-cyclophosphamide and ifosfamide-etoposide, along with primary tumor treatment with surgery or radiotherapy or both, constitute the usual treatment of Ewing sarcoma. The AEWS0031 study demonstrated survival benefits after interval-compressed chemotherapy without significant toxicity. The aim of this study was to assess the tolerability of dose-intensified chemotherapy in developing countries like India.

Bow Hunter's Syndrome with Rotational Atlantoaxial Instability: A Rare Association.

Bow Hunter's syndrome (BHS) is a very rare condition in which there is rotational vertebral artery (VA) insufficiency. The association of BHS with rotational atlantoaxial instability is extremely rare. We are reporting a case of pediatric BHS who presented with features of VA insufficiency on neck rotation.

Knockdown of the Autophagy Protein Beclin-1 Does Not Affect Innate Cytokine Production in Human Lung Epithelial Cells during Respiratory Syncytial Virus Infection.

Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in young children, globally. Autophagy is a cellular degradation process that mediates cell survival. Studies using mouse models have demonstrated that inhibiting autophagy affects the production of cytokines triggered by RSV.

Variations in mitochondrial DNA control region among Malay and Chinese subpopulations (sequence 16000-16200).

DNA variations are alterations found in DNA sequence, occurring in both nuclear DNA and mitochondrial DNA. Variations might differ in individual following population, respectively. The aim of this study was to find variations in target sequence of mtDNA (16000-16200) to be used as marker in Malay and Chinese population.

Hematological malignancies presenting as spontaneous tumor lysis syndrome: A case series.

Tumor lysis syndrome is an oncological emergency caused by massive tumor lysis resulting in a constellation of metabolic abnormalities. It is observed most frequently in patients with high-grade hematological malignancies undergoing treatment. Tumor lysis syndrome can occur spontaneously and it can present as the first symptom of an underlying malignancy.

Antioxidant, anticancer and electrochemical redox properties of new bis(2,3-dihydroquinazolin-4(1H)-one) derivatives.

In this paper, a series of bis(2,3-dihydroquinazolin-4(1H)-one) derivatives (4a-i, 10a-k) were synthesized by the one-pot pseudo-five-component reaction of isatoic anhydride with aromatic aldehydes and aromatic amines under reflux in glacial acetic acid. The synthesized compounds were screened for their antioxidant properties using the DPPH radical scavenging method. Compounds 4i and 10h showed potent radical scavenging activities at 20 [Formula: see text] compared to BHA and ascorbic acid.

"Venous congestion" as a cause of subcortical white matter T2 hypointensity on magnetic resonance images.

Subcortical T2 hypointensity is an uncommon finding seen in very limited conditions such as multiple sclerosis, Sturge-Weber syndrome, and meningitis. Some of the conditions such as moyamoya disease, severe ischemic-anoxic insults, early cortical ischemia, and infarcts are of "arterial origin." We describe two conditions in which "venous congestion" plays a major role in T2 hypointensity - cerebral venous sinus thrombosis (CVST) and dural arteriovenous fistula (dAVF).

Synthesis of novel bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-dione) and its derivatives: evaluation of their antioxidant properties.

One pot cyclocondensation reaction of barbituric/thiobarbituric acid with aromatic aldehydes and p-phenylenediamine/2,6-diaminopyridine by refluxing in glacial acetic acid afforded novel bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-diones)/pyrido bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-diones. All the synthesized compounds were screened for their antioxidant activities using FRAP and DPPH methods. Compounds with chloro substituents showed relatively good antioxidant properties.

Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements.

Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application.

Iterative method for the inversion of multiwavelength lidar signals to determine aerosol size distribution.

Two iterative methods of inverting lidar backscatter signals to determine altitude profiles of aerosol extinction and altitude-resolved aerosol size distribution (ASD) are presented. The first method is for inverting two-wavelength lidar signals in which the shape of the ASD is assumed to be of power-law type, and the second method is for inverting multiwavelength lidar signals without assuming any a priori analytical form of ASD. An arbitrary value of the aerosol extinction-to-backscatter ratio (S(1)) is assumed initially to invert the lidar signals, and the ASD determined by use of the spectral dependence of the retrieved aerosol extinction coefficients is used to improve the value of S(1) iteratively.

Nonlinear directional coupler in periodically poled lithium niobate.

Nonlinear wave propagation was investigated experimentally in coupled waveguides by means of the cascaded nonlinearity in quasi-phase-matched second-harmonic generation. With a specially designed wave-vector-mismatch distribution along the propagation axis, cascading was optimized for low fundamental depletion. High-contrast, ultrafast all-optical switching with switching powers of tens of watts was observed.

Multiple-channel wavelength conversion by use of engineered quasi-phase-matching structures in LiNbO(3) waveguides.

We report difference frequency generation-based wavelength converters with multiple phase-matching wavelengths that use engineered quasi-phase-matching structures in LiNbO(3) waveguides. Multiple-channel wavelength conversion is demonstrated within the 1.5-mum band and between the 1.