Publications by authors named "Parajuli D"

Pb₁₋ₓ₋₃BaₓReᵧ³⁺Nb₂O₆ (PBN) ceramics, where x = 0.35 and y = 0.00, 0.

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Background: Alcohol use disorder (AUD) with chronic and heavy alcohol consumption causes alcohol-associated liver disease (ALD). Early-stage ALD exhibits dyshomeostasis of zinc. We investigated the role of zinc deficiency in gut-barrier dysfunction, proinflammatory response, hepatocyte injury, and death, as well as potential sex differences in AUD patients.

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  • Health literacy is vital for health and well-being, but studies in Nepal on this topic are limited; this research assessed health literacy levels in adults from Rasuwa.
  • A cross-sectional study involving 253 adults revealed that only 23.3% had adequate health literacy, with younger participants and those reporting satisfactory health and financial conditions being more likely to demonstrate higher literacy levels.
  • Factors like age, self-assessed health status, financial stability, self-esteem, and income influenced health literacy; addressing these socio-economic issues is crucial for improving health literacy, especially among vulnerable groups.
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The article discusses the promising synergy between MXenes and polymers in developing advanced nanocomposites with diverse applications in biomedicine domains. MXenes, possessing exceptional properties, are integrated into polymer matrices through various synthesis and fabrication methods. These nanocomposites find applications in drug delivery, imaging, diagnostics, and environmental remediation.

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This quasi-experimental, nonrandomized intervention study reports the effect of person-centred, culturally appropriate music on psychological wellbeing of residents with advanced dementia in five rural residential aged care homes in Australia. Seventy-four residents attended in person-centred music sessions and culturally appropriate group sessions. Interest, response, initiation, involvement, enjoyment, and general reactions of the residents were assessed using the Music in Dementia Assessment Scale (MiDAS), and interviews and focus groups were conducted with aged care staff and musicians.

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In this work, a numerical assessment of the optoelectrical properties of the ZnO-ZnSe-CdSe heterojunction for a thin and cost-effective solar cell was made by using the PC1D simulation software. The photovoltaic (PV) properties have been optimized by varying thicknesses of the absorber layer of the p-CdSe layer, the window layer of n-ZnSe, and the antireflection coating (ARC) layer of ZnO, a transparent conductive oxide with enhanced light trapping, and wide bandgap engineering. There is a positive conduction band offset (CBO) of ΔEc = 0.

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  • The CONFIRM trial aimed to compare the effectiveness of annual fecal immunochemical tests (FIT) versus colonoscopies in reducing colorectal cancer mortality, enrolling over 50,000 veterans between May 2012 and December 2017.
  • The study analyzed participant demographics and examined reasons for those who chose not to participate, highlighting a mix of preferences for either colonoscopy or stool tests based on geographic and temporal factors.
  • Among the 50,126 participants recruited, there was a diverse representation, and the study also noted that 11,109 eligible individuals opted out of participation for various reasons, with insights gathered via case report forms.
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Angiosarcoma is a rare mesenchymal tissue neoplasm, typically involving lymphatic or vascular endothelial cells. The tumor can arise anywhere in the body, though it is most often found as cutaneous lesions in the head and neck region. Due to its rarity, a diagnosis can sometimes be missed, especially when the sarcoma involves an uncommon site like the gastrointestinal tract.

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Introduction: Hypomagnesemia has been documented in alcohol-associated liver disease (ALD). This study aims to characterize hypomagnesemia in alcoholic hepatitis (AH) patients and identify its response with liver injury and severity markers.

Materials And Methods: A total of 49 male and female AH patients with an age range of 27-66 years were enrolled in this study.

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  • The study explores a new method to enhance shunt catheters used for treating hydrocephalus by adding antibiotic-loaded nanospheres to prevent bacterial infections.
  • Clindamycin, rifampicin, and trimethoprim were incorporated into these nanospheres, with varying drug-loading content based on their ratios in the polymer formulation.
  • The results showed effective antibacterial properties that lasted for 21 days, confirming the potential of this method in improving shunt-related infection prevention.
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Background: Clinically significant serrated polyp detection rate (CSSDR) and proximal serrated polyp detection rate (PSDR) have been suggested as the potential quality benchmarks for colonoscopy (CSSDR = 7% and PSDR = 11%) in comparison to the established benchmark adenoma detection rate (ADR). Another emerging milestone is the detection rate of lateral spreading lesions (LSLs).

Objectives: This study aimed to evaluate CSSDR, PSDR, ADR, and LSL detection rates among gastrointestinal (GI) fellows performing a colonoscopy.

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(1) Background: Heavy and chronic alcohol drinking leads to altered gut dysfunction, coupled with a pro-inflammatory state. Thyroid-associated hormones and proteins may be dysregulated by heavy and chronic alcohol intake; however, the mechanism for altered gut-derived changes in thyroid function has not been studied thus far. This study investigates the role of alcohol-induced gut dysfunction and pro-inflammatory cytokine profile in the thyroid function of patients with alcohol use disorder (AUD).

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Background: Locus of control (LoC) is a social cognition, that relates to the level of self-control that people have over their personal environment that influences their life. In this context, LoC is frequently associated with work-related behavioral outcomes, ranging from job attitudes, career behaviors, stress, and burnout.

Objective: To investigate the association between LoC, and work-related behavioral factors, socio-cultural factors, and personal factors among Australian General Practitioners (GPs).

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MXenes are 2D ceramic materials, especially carbides, nitrides, and carbonitrides derived from their parent 'MAX' phases by the etching out of 'A' and are famous due to their conducting, hydrophilic, biocompatible, and tunable properties. However, they are hardly stable in the outer environment, have low biodegradability, and have difficulty in drug release, etc., which are overcome by MXene/Polymer nanocomposites.

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This Special Issue covers the widely studied topic of "Adsorbents", materials that are known to uptake ions and molecules from water or air [...

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The purpose of this paper is to provide an overview of the pharmacy practice and initiatives taken by the Australian federal government to ensure the continued supply of essential medicines under the conditions of an emergency response plan for COVID-19. During the pandemic, Australian pharmacists have been working collaboratively with multidisciplinary teams at the frontline to manage the equitable and safe supply of medicines despite the unprecedented situation. Although these presented problems for small pharmacies, social distancing policies were implemented widely to maintain personal and environmental hygiene and reduce the number of face-to-face patient visits.

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Background: (1) To determine the prevalence of hepatopancreatic injury in coronavirus disease 2019 (COVID-19) patients. (2) To correlate hepatopancreatic injury in COVID-19 with mortality, disease severity, and length of stay in this cohort.

Results: Forty-five thousand three hundred sixty patients were included in the analysis, 62.

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One of the strategies to realize a nitrogen cycle society, we attempted to recover ammonium ions from industrial wastewater, especially sewage water with adsorbent materials. We have developed an adsorbent with high ammonium selectivity based on copper hexacyanoferrate and granulated it as pellets. Using a compact column system filled with this granule adsorbent, ammonium ions were recovered from sewage containing 1000-1500 mg-NH/L ammonium ions.

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Cobalt Hexacyanoferrate (CoHCF) was tested for the selective uptake of K from seawater and the electrochemical method was adopted for the desorption and regeneration of the material. Powder form CoHCF could adsorb about 6.5 mmol/g of K from the seawater.

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Prussian blue analogs (PBA) are widely studied for radioactive cesium decontamination. However, there are fewer works related to their post use storage. Considering the oxidative stabilization of the material after the selective uptake of Cs, the thermogravimetric properties in powder and bead form, with various Cs and other alkali metal ions adsorbed, and various heating rates were studied.

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Background: Studies have demonstrated that heart failure (HF) patients who receive direct pharmacist input as part of multidisciplinary care have better clinical outcomes. This study evaluated/compared the difference in prescribing practices of guideline-directed medical therapy (GDMT) for chronic HF patients between two multidisciplinary clinics-with and without the direct involvement of a pharmacist.

Methods: A retrospective audit of chronic HF patients, presenting to two multidisciplinary outpatient clinics between March 2005 and January 2017, was performed; a Multidisciplinary Ambulatory Consulting Service (MACS) with an integrated pharmacist model of care and a General Cardiology Heart Failure Service (GCHFS) clinic, without the active involvement of a pharmacist.

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Goal: A comprehensive review of treatments for nausea and vomiting (N/V).

Background: N/V are common symptoms encountered in medicine. While most cases of acute N/V related to a specific cause can be straightforward to manage, other cases of acute N/V such as chemotherapy-induced N/V and especially chronic unexplained N/V can be difficult to control, leading to a significant decline in the patient's quality of life and increased cost of medical care from repeated hospitalizations.

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Background: High rates of psychotropic medications are prescribed in aged care homes despite their limited effectiveness and associated adverse effects. We aim to evaluate the changes in prescription patterns for elderly residents with dementia in the 'Harmony in the Bush Dementia Study'. Harmony in the Bush is a person-centered model of dementia care in nursing homes, based on the principles of Progressively Lowered Stress Threshold and person-centered music intervention.

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