Publications by authors named "Papp A"

We investigate the effect of focused-ion-beam (FIB) irradiation on spin waves with sub-micron wavelengths in Yttrium-Iron-Garnet (YIG) films. Time-resolved scanning transmission X-ray (TR-STXM) microscopy was used to image the spin waves in irradiated regions and deduce corresponding changes in the magnetic parameters of the film. We find that the changes of Gairradiation can be understood by assuming a few percent change in the effective magnetizationof the film due to a trade-off between changes in anisotropy and effective film thickness.

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Background/aim: Enhanced recovery after surgery (ERAS) protocol is adopted in clinical practice worldwide, but a lack of evidence for measurable benefits after upper gastrointestinal (GI) surgeries can be detected especially regarding early oral feeding.

Patients And Methods: A propensity score-matching study was conducted at the Department of Surgery of the University of Pécs between January 2020 and December 2023. The study included patients who underwent upper GI cancer surgery and were treated according to an early oral feeding protocol (EOF).

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Our study investigates the potential correlation between generational differences, like age and previous experience with digital innovations, such as video games and smartphones, and the performance on the Da Vinci Skills Simulator, the cornerstone of robotic surgery training. Thirty participants were involved from three age groups: Generation Alpha, Generation Z, and Generation X. None had prior robotic surgical experience.

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In this publication various serum biochemistry and haematology parameters were determined from blood samples obtained from captive adult individuals of an exotic quail species, the mountain quail (Oreortyx pictus, Douglas, 1829). Venipuncture was performed in the second half of the breeding season from six roosters (males) and seven hens (females). During the examination, in addition to the haematological elements, basic parameters of serum enzyme levels, the products of protein metabolism, uric acid and the most important ions were monitored.

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Before metabolic and bariatric surgery (MBS), moderate weight loss and liver left lateral section (LLLS) volume reduction are desirable. Low-carb ketogenic diet-induced weight loss before MBS has been shown to have beneficial effects on the reduction in body weight (BW) and LLLS. However, the nutritional protocol of low-carb ketogenic diet may be hard to keep for prolonged periods due to the lack of sweet taste.

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Article Synopsis
  • Obesity involves low-grade inflammation mainly due to expanding visceral fat, where fat cells (adipocytes) enlarge and die, leading to the recruitment of macrophages that become pro-inflammatory over time.
  • The study explores the role of Mer tyrosine kinase in macrophages, initially hypothesizing it offers protection against obesity, but findings revealed that mice without Mer actually had better resistance to high-fat diet-induced obesity.
  • Additionally, Mer is found in fat cells, enhancing their ability to store lipids while reducing thermogenesis in brown fat, indicating Mer influences how the body handles excess fats.
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  • This study evaluated the effectiveness of a biosimilar drug, QL1205, compared to the established drug ranibizumab (Lucentis®) in patients with neovascular age-related macular degeneration (nAMD) through a rigorous phase 3 trial.* -
  • A total of 616 treatment-naïve patients were randomly assigned to receive either QL1205 or ranibizumab, and both groups were given injections every four weeks for 48 weeks, with the main focus on changes in best-corrected visual acuity (BCVA).* -
  • Results showed similar improvements in visual acuity for both QL1205 (+6.3 letters) and ranibizumab (+7.
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The introduction of robot-assisted minimally invasive esophageal surgery (RAMIE) represents a significant advancement in minimally invasive surgery. The robot system typically includes a high-resolution 3D camera and specially maneuverable instruments that are controlled by the surgeon from a console. By reducing the trauma caused by the intervention, this method allows for faster recovery compared to traditional open surgeries.

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Article Synopsis
  • * A review of nine randomized controlled trials (RCTs) involving 529 patients indicated no significant differences in mortality, anastomosis leakage, respiratory issues, or vomiting, though results regarding gastric emptying time (GET) presented mixed findings.
  • * The study suggests that pyloric drainage is not essential in these operations, but emphasizes the need for further research, especially in European contexts, to draw more definitive conclusions.
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Objective: To demonstrate the therapeutic similarity of CT-P42 compared with reference aflibercept (Eylea) in adult patients with diabetic macular edema (DME).

Design: Randomized, active-controlled, double-masked, phase III clinical trial PARTICIPANTS: Patients with a diagnosis of either type 1 or 2 diabetes mellitus with DME involving the center of the macula.

Methods: Patients were randomized (1:1) to receive either CT-P42 or reference aflibercept (2 mg/0.

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To compare the efficacy and safety of the proposed aflibercept biosimilar SCD411 and reference aflibercept in patients with neovascular age-related macular degeneration, this randomized, double-masked, parallel-group, multicenter study was conducted in 14 countries from 13 August 2020 to 8 September 2022. Patients with neovascular age-related macular degeneration. With subfoveal, juxtafoveal, or extrafoveal choroidal neovascularization were aged 50 years or older.

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Acute kidney injury (AKI) is a common complication of severe burn injury and is associated with significant morbidity and mortality. Continuous Renal Replacement Therapy (CRRT) is the preferred treatment for stage 3 AKI due to severe burn. This retrospective cohort study at a single institution aimed to examine the long-term renal outcomes after discharge of burn survivors who underwent CRRT during their ICU stay between 2012-2021 due to burn-related AKI, hypothesizing a return to baseline renal function in the long term.

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Physical activity is an especially important part of everyday life for children with chronic diseases. The aim of the study was to show whether asthma is a barrier to physical activity in our society. The correlations between the severity of the disease, body mass index, and physical activity were analyzed, and parents' opinions on whether children should participate in active sports were assessed.

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Background: Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer; however, the superiority of neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy (nCRT) is unclear. Therefore, a discussion of these two modalities is necessary.

Aim: To investigate the benefits and complications of neoadjuvant modalities.

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Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes. The proper regulation of the complement system is important to allow its sufficient and targeted activity without deleterious side-effects. Factor H is a major complement regulator, and together with its splice variant factor H-like protein 1 and the five human factor H-related (FHR) proteins, they have been linked to various diseases.

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Article Synopsis
  • The AZURE study was a 76-week clinical trial comparing two treatment regimens of aflibercept in patients with neovascular age-related macular degeneration, evaluating a flexible treat-and-extend approach versus a fixed dosing schedule.
  • Patients aged 51 and older who had been on aflibercept for at least a year were randomly assigned to receive either a treat-and-extend regimen or fixed dosing every 8 weeks, with changes monitored based on visual acuity and anatomical results.
  • Results showed that both regimens produced similar changes in best-corrected visual acuity, with high rates of vision maintenance, and the treat-and-extend approach allowed for longer intervals between treatments for some patients without any new safety concerns.
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Purpose: The demographic proportions of plastic surgery trials approximating real-world disease have not well been studied. Judicious trial representation is essential in evaluation of treatments across diverse patient populations. Herein, we investigate sex, racial, and ethnic disparities in patient enrollment across burn trials.

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Skeletal muscle regeneration is a complex process orchestrated by multiple interacting steps. An increasing number of reports indicate that inflammatory responses play a central role in linking initial muscle injury responses to timely muscle regeneration following injury. The nucleoside adenosine has been known for a long time as an endogenously produced anti-inflammatory molecule that is generated in high amounts during tissue injury.

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Glioblastoma multiforme (GBM) and malignant gliomas are the most common primary malignant brain tumors. Temozolomide (TMZ) chemotherapy plus radiation therapy (RT), admi-mistered after debulking surgery, increased the median survival time (MST) from 12.1 months with RT alone merely to 14.

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Less invasive surfactant administration techniques, together with nasal continuous airway pressure (LISA-nCPAP) ventilation, an emerging noninvasive ventilation (NIV) technique in neonatology, are gaining more significance, even in extremely premature newborns (ELBW), under 27 weeks of gestational age. In this review, studies on LISA-nCPAP are compiled with an emphasis on short- and long-term morbidities associated with prematurity. Several perinatal preventative and therapeutic investigations are also discussed in order to start integrated therapies as numerous organ-saving techniques in addition to lung-protective ventilations.

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Background: (, the causative bacterium of tuberculosis (TB), establishes residence and grows in human alveolar macrophages (AMs). Inter-individual variation in -human AM interactions can indicate TB risk and the efficacy of therapies and vaccines; however, we currently lack an understanding of the gene and protein expression programs that dictate this variation in the lungs.

Results: Herein, we systematically analyze interactions of a virulent strain HR with freshly isolated human AMs from 28 healthy adult donors, measuring host RNA expression and secreted candidate proteins associated with TB pathogenesis over 72h.

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