Identification of a Distinct Monocyte-Driven Signature in Systemic Sclerosis Using Biophysical Phenotyping of Circulating Immune Cells.

Objective: Pathologically activated circulating immune cells, including monocytes, play major roles in systemic sclerosis (SSc). Their functional characterization can provide crucial information with direct clinical relevance. However, tools for the evaluation of pathologic immune cell activation and, in general, of clinical outcomes in SSc are scarce.

[MORPHOLOGICAL ALTERATIONS IN THE INTERNAL ORGANS OF RATS WITH ALLOXAN DIABETES].

The aim of our study was to assess morphological changes in internal organs in a redox-induced model of alloxan diabetes in rats.According to the results of the study, the blood glucose level in rats began to increase 24 hours after the of alloxan administration, reached the maximum level on the 15th day of observation, and decreased on the 25-35 day, to the control level. In parallel with the increase in blood glucose level, an increase in the malondialdehyde (MDA) content in the blood serum was observed.

BIOCHEMICAL ASPECTS OF SYMPTOMATIC TREATMENT IN PATIENTS WITH COVID-19 (REVIEW).

The new Coronavirus has challenged modern medicine. The disease caused by this virus, COVID-19, is characterized by a high rate of lethality, especially in the older age group. There is still no vaccine and no specific treatment, therefore prevention remains the main way to fight the virus.

Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia.

We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress.

[The role of some pituitary hormones in patients with non-insulin-dependent diabetes mellitus and diabetic retinopathy].

The level of somatotropin and thyreotropin hormones was measured in blood plasma of patients with non-insulin-dependent diabetes mellitus with and without diabetic retinopathy (DR). Fifty eight patients (26 males and 32 females) aged from 35 to 75 were examined. The patients were divided into two groups.

[Activity of antioxidative ferments during obesity of different degree].

The purpose of our research was to define influence of dislipidemia on the redox-system, developed during obesity. 150 patients from 18 to 55 years were examined having obesity of a different degrees who have been admitted to the endocrinology department of 4-th clinical hospital of Tbilisi. On the basis of the analysis of the received data it is possible to conclude that with in a degree of obesity a deterioration of parameters of lipid exchange was observed which from its part exerts its influence on the redox-system of an organism.

[Plaferon LB as a modulator of the activity of transport protein complexes of mitochondrial respiratory chain].

Mitochondrial energogenesis plays key role in the vital activity of cells. Regulation of its intensity is especially important for the maintenance of function of tissues and body internal organs under different pathological conditions. There are numerous studies demonstrating modulator effect of domestic preparation, plaferon LB (USA patent number WO02/ 12444 A2) on the intensity of mitochondrial respiration in vivo at different pathological processes.

[Effectiveness of plaferon LB in gamma-radiotherapy].

Free radical oxidation plays important role in the radiation-induced cell and tissue damage. Numerous studies evidence a decrease in body antioxidant system activity and changes in nitric oxide levels during irradiation. It has been demonstrated that in the process of radiation damage NO may play either radioprotective or radiotoxic role depending on body redox status.

Secretion of sex hormones in patients with open angle glaucoma.

Our study included 71 patients (38 males and 33 females) with diagnosed open angle glaucoma and 71 healthy persons in the control group. Their age ranged from 45 to 70. The patients and healthy persons were divided into three groups: I group - 45-55 years old persons, II group - 55-65 years old persons, III group - 65-75 years old persons.

[Limbo-sclerotomy--a refractive procedure outside the cornea. Preliminary report].

Background: Complications of refractive corneal procedures are a consequence of inevitable corneal deformation or thinning. We aim to reduce corneal refractive power but omit laceration on the cornea itself.

Methods: 1.

[Effect of the antioxidant ionol on myocardial energy metabolism and the course of traumatic shock].

Energy metabolism was studied in experiments on rats with due regard for the individual features of the organism's reaction to trauma. The animals were divided into 2 subgroups according to the survival period during the experiment. Disorders of mitochondrial function were revealed in both subgroups, but they differed in degree according to the severity of the process.

[Mechanism of activation of the external pathway of NADH oxidation in myocardial mitochondria during hemorrhagic shock].

The changes in the oxidative metabolism of rabbit myocardium in hemorrhagic shock were studied. The external pathway of NADH oxidation was shown to be activated, while the rates of glutamate oxidation in the presence of an uncoupler were diminished as compared to control values. These changes are probably due to the activation of phospholipase A2 and lipid peroxidation, since their inhibitors eliminate with the same efficiency the activation of the external pathway of NADH oxidation both in normal and damaged myocardium.