Outcome following treatment for Helicobacter pylori in patients with recurrent aphthous stomatitis.

Objective: The aim of the current study was to investigate any association of Helicobacter Pylori (HP) in recurrent aphthous stomatitis (RAS) and the effect of eradication of the microorganism in the clinical course of the disease.

Study Design: Forty-eight patients with RAS were included in the study. Twenty-six were women and 22 men, of average age 41.

Treatment of chronic sialadenitis by intraductal penicillin or saline.

Purpose: We sought to describe the treatment of chronic sialadenitis by intraductal penicillin or saline.

Patients And Methods: The study group consisted of 32 males and 23 females with chronic submandibular sialadenitis aged 12 to 65 years and 16 males and 11 females with chronic parotitis aged 8 to 65 years who were treated by intraductal instillation of penicillin or saline.

Results: In the patients with submandibular sialadenitis, 44 patients treated with penicillin and 11 treated with saline became symptom free; symptoms recurred in 3 treated with penicillin, of whom 2 became symptom free after further instillations and 1 after removal of a sialolith at the ductal orifice; and follow-up of 22 patients verified that 18 treated with penicillin and 4 with saline had been symptom free for 1 to 15 years and 1 to 3 years, respectively.

Epidermal growth factor in saliva and serum of patients with cyclosporin-induced gingival overgrowth.

The purpose of this study was to investigate the presence of epidermal growth factor (EGF) in patients receiving cyclosporin therapy who had gingival overgrowth and to determine whether there were any differences between these patients and normal healthy controls. Seventeen patients with cyclosporin-induced gingival overgrowth and seventeen age- and sex-matched controls who were taking cyclosporin but had healthy gingiva were used for this study. Unstimulated whole saliva was collected from all individuals by expectoration.

Benign tumors of adipose tissue of the oral cavity: a clinicopathologic study of 13 cases.

Purpose: The purpose of this study was to determine the clinical and histologic features of 9 simple lipomas, 2 fibrolipomas, and 2 infiltrating lipomas of the oral cavity. In addition, 10 cases of infiltrating lipoma of the oral cavity previously reported in the literature were reviewed.

Materials And Methods: All cases were retrieved from the archives of the Department of Oral Medicine/Pathology of the University of Thessaloniki, Greece.

Tumor-associated glycoprotein 72 (TAG-72) expression in salivary gland neoplasia: an immunohistochemical study using the monoclonal antibody (MAb) CC49.

Objectives: The purpose of this study was to investigate immunohistochemically the expression of tumor-associated glycoprotein 72 (TAG-72) using the monoclonal antibody (MAb) CC49 in salivary gland neoplasia and normal salivary glands in an attempt to determine the potential usefulness of MAb CC49 in diagnostic and therapeutic applications.

Materials And Methods: Eighty-six specimens (21 benign tumors, 41 malignant, and 24 normal salivary glands), fixed in 10% formalin and embedded in paraffin, were retrieved from the files of the Department of Oral Medicine and Oral Pathology at the Dental School of Aristotle University, Thessaloniki, Greece, and were retrospectively studied with hematoxylin and eosin and with the streptavidin-biotin-complex method using the MAb CC49.

Results: Strong immunoreactivity for TAG-72 was observed in salivary duct carcinoma, adenocarcinoma, papillary cystadenocarcinoma, low-grade mucoepidermoid carcinoma, normal submandibular, sublingual, and minor salivary glands.

Immunohistochemical detection of insulin-like growth factor-I in the labial salivary glands of patients with Sjögren's syndrome.

Objective: The purpose of the present study was to investigate the presence of insulin-like growth factor-I (IGF-I) in the labial salivary glands of patients with Sjögren's syndrome and healthy controls and to determine if there are any differences between these two groups.

Design: An immunohistochemical study.

Subjects And Methods: Twenty-five patients with Sjögren's syndrome, 20 healthy controls and 20 patients with mucoceles of the lip were used in this study.

Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes.

Objective: The purpose of the present study was to determine the prevalence of oral lichen planus (OLP) in a population of patients with diabetes mellitus (DM) as compared with a control population.

Design: A clinicopathologic study.

Subjects And Methods: One hundred and thirty-nine patients with type I DM, 353 patients with type II DM and 274 controls were examined for clinical evidence of OLP.

Tumor-associated glycoprotein (TAG-72) in chronic submandibular sialadenitis and normal minor salivary glands defined by monoclonal antibody B72.3.

Formalin-fixed, paraffin-embedded samples of three normal minor salivary glands, 10 chronic submandibular sialadenitis, and three normal submandibular glands were studied immunohistochemically using the monoclonal antibody (Mab) B72.3 in order to have a better understanding of the distribution of tumor-associated glycoprotein (TAG-72). Diffuse expression of TAG-72 was observed in the mucous cells of normal minor salivary glands, and in the ducts with goblet cell metaplasia and/or hyperplasia of chronic submandibular sialadenitis (eight of 10).

Malignant potential of oral lichen planus; a follow-up study of 326 patients.

326 patients with oral lichen planus were followed for periods ranging from 6 months to 10 years (mean 4.8 years), in an attempt to clarify the malignant potential of this disease which is still controversial. Malignant transformation occurred in 4 patients (1.

Desquamative gingivitis: a clinical, histopathologic, and immunologic study.

Desquamative gingivitis is believed to be a clinical sign of certain mucocutaneous diseases rather than a distinct pathologic entity. The prevalence of desquamative gingivitis was studied in a group of patients with the most common mucocutaneous diseases. Of 414 patients with pemphigus vulgaris, mucous membrane pemphigoid, or oral lichen planus, 49 (11.

Immunohistochemical evaluation of TGF-beta and extracellular matrix proteins expression in rat squamous cell carcinomas.

Objective: The aim of this study was to establish a possible association between the degree of differentiation of squamous cell carcinomas (SCC) derived from rat oral tissues treated in vivo with carcinogen 4NQO, and the expression of TGF-beta on epithelial cells and the distribution of extracellular matrix proteins (laminin-collagen type IV).

Materials And Methods: A parent tumor showing a spectrum of differentiation was used to establish clonal subpopulations that formed differentiated SCC and undifferentiated (spindle cell phenotype) tumours following transplantation to athymic mice.

Results: Immunohistological findings revealed the absence of TGF-beta staining on epithelial cells and extracellular matrix proteins in spindle cell tumours.

Squamous cell carcinoma of the lips in a northern Greek population. Evaluation of prognostic factors on 5-year survival rate--I.

The purpose of this study was to determine the clinical features of squamous cell carcinoma (SCC) of the lips, along with its prognostic factors, in order to extend and update the information related to lip cancer in northern Greece and to provide a basis for international comparison. Records of 1510 patients with SCC of the oral cavity presented at the Theagenion Anticancer Institute of Thessaloniki, Greece from 1979 and 1989 were reviewed. The most common site for oral squamous cell carcinoma (OSCC) was found to be the lips (59.

Immunologic status in patients infected with HIV with oral candidiasis and hairy leukoplakia.

Although numerous studies of oral manifestations associated with HIV have been reported, only a few refer to the correlation of these lesions with laboratory parameters. In this study we investigated the relationships between the two most common HIV-associated oral lesions, oral candidiasis and hairy leukoplakia, with the stage of the disease, circulating CD4+ cell counts, and the presence of anti-p24 antibodies in serum and stimulated whole saliva in 43 known HIV-1-infected persons. Although oral candidiasis and hairy leukoplakia were exclusively observed in subjects who were classified as Centers for Disease Control and Prevention group IV, only the prevalence of oral candidiasis is strongly associated with circulating CD4+ counts less than 200/mm3 (p < 0.

Median rhomboid glossitis. An oral manifestation in patients infected with HIV.

A follow-up study included the oral examination of 39 persons known to be infected with the human immunodeficiency virus. In addition to the other human immunodeficiency virus-associated oral lesions, lesions clinically similar to the smooth form of median rhomboid glossitis, which is now believed to be erythematous candidiasis located in the dorsum of the tongue, were found in seven patients (18%). Patients with median rhomboid glossitis were classified in different stages of the Centers for Disease Control 1986 classification system and showed an average of CD+4 cell counts 397.

Kaposi's sarcoma of the oral cavity: case reports.

Classic Kaposi's sarcoma is a rare malignant neoplasm of endothelial cell origin. Oral manifestation of Kaposi's sarcoma is even more uncommon. The purpose of this article is to describe two cases of classic Kaposi's sarcoma and to discuss the current knowledge regarding its pathogenesis, epidemiology, clinical characteristics, and therapy.

The role of the time of application of the promoter in two-stage chemically induced carcinogenesis in the oral mucosa: experimental study in the rat.

The purpose of this study is to determine the role of the time of application of the promoter (in this case, mechanical irritation) in two-stage chemically induced oral carcinogenesis. One hundred fifty-five male rats were divided into seven groups. Group 1, 2 and 3 each received two intraperitoneal injections of the carcinogen N-nitroso-N-methylurea (NMU): 50 mg/Kg BW.

Reticulohistiocytic granuloma of the tongue: a case report.

Reticulohistiocytic granuloma is a type of reticulohistiocytosis that is manifested without systemic disturbances. A rare case of reticulohistiocytic granuloma presenting as a solitary nodule on the tongue is reported and discussed.

Cyclosporin-induced gingival hyperplasia: an ultrastructural study of the oral epithelial prickle cells.

In this study the ultrastructural characteristics of the prickle cells of the human gingival epithelium after cyclosporin-A treatment are described. The prickle cell layer shows hyperplasia, along with the well known hyperplasia of the connective tissue components. The prickle cells show large numbers of free ribosomes, rough endoplasmic reticulum profiles and well developed Golgi complexes.

[Treatment of sialolithiasis and its complications with intraglandular injection of biotherapeutic solution].

The creation of sialoliths in the ductal system of major salivary glands causes characteristic symptoms due to the obstruction of the flow of produced saliva. If sialolithiasis is not treated early obstructive sialadenitis will develop and its repeated relapses may lead to fibrosis and degeneration of glandular parenchyma. In this study we present the method of intraglandular injection of biotherapeutic solution (1.

[Lateral periodontal cyst with keratinization (odontogenic keratocyst). Case report].

The purpose of this study was to present the clinical and histological features of one case of lateral periodontal cyst with keratinization. The incidence, the histological features and the aetiopathogenesis of this type of cyst that is recurred were discussed.

Submucous dirofilariasis involving the cheek. Report of a case.

Dirofilariasis is characterized by the presence of numerous filarial worms in the subcutaneous tissues, and by the formation of subcutaneous nodules. The clinical symptoms and histologic features of the disease are discussed, together with a case report from Greece.

[Hyperhaplotypes of A, B and DR loci of HLA region in patients with recurrent aphthous ulceration].

Recurrent aphthous ulceration is a common disease affecting 10% of the general population. It is speculated that there is a genetic predisposition for the disease and for this reason HLA antigens may be involved. In our research we investigated 103 Greek patients suffering from recurrent aphthous ulcers (RAU) ranging in age from 13 to 60 years.

[Diagnosis of deep head and neck infections with the aid of CT-scanning: report of a case].

A case with masseteric and temporal abscess formation is reported in which the use of CT-Scanning is demonstrated. We believe that CT is a valuable adjunct in confirmation of the presence of an abscess in the deep head and neck spaces and for CT guided aspiration of purulent material, in order to have the possibility of a culture prior to the drainage of the abscess.

[Clinical study of sialolithiasis. Findings from 100 cases].

The present work is based on a study of 100 cases of sialolithiasis referred to the Department of Oral Medicine, Dental School, University of Thessaloniki during the period 1963-1986. Among 100 cases sialolithiasis was distributed as following: Submandibular glands 89 cases, parotids 8 cases and minor salivary glands 3 cases. Sialolithiasis of sublingual glands were not found.