Local recurrences after DIEP reconstruction of the breast - Epidemiology and strategies for treatment.

Breast cancer is the most common cancer diagnosed in women. Breast reconstruction can be performed with autologous fat tissue, implants, or a combination of both. Overall, there is no increased risk of breast cancer recurrence after autologous breast reconstruction compared to mastectomy alone.

Boys vs men differences in muscular fatigue, muscle and cerebral oxygenation during maximal effort isometric contractions: the effect of muscle blood flow restriction.

Purpose: To examine whether the children's superiority, over adults, to resist fatigue during repeated maximal-efforts depends on their often-cited oxidative advantage, attributed to greater muscle blood flow and O-delivery. We also investigated the mechanisms underlying child-adult differences in muscle-oxygenation (due to O-supply or O-utilization) and examined if there are age-differences in cerebral-oxygenation response (a brain-activation index).

Methods: Eleven men (23.

Abscopal effect induced by cryoablation in a 55-year-old patient with metastatic dedifferentiated liposarcoma: a case report.

Background: Metastatic dedifferentiated liposarcoma (DDLPS) is primarily managed with chemotherapy, yet with poor response rate. Locoregional therapies, such as radiotherapy and percutaneous cryoablation, can provide palliation for inoperable metastatic sarcomas. In rare instances, those ablative therapies can elicit an immune-mediated regression of untreated metastases in a process named the abscopal effect.

FLAC: Fairness-Aware Representation Learning by Suppressing Attribute-Class Associations.

Bias in computer vision systems can perpetuate or even amplify discrimination against certain populations. Considering that bias is often introduced by biased visual datasets, many recent research efforts focus on training fair models using such data. However, most of them heavily rely on the availability of protected attribute labels in the dataset, which limits their applicability, while label-unaware approaches, i.

PolyMeme: Fine-Grained Internet Meme Sensing.

Internet memes are a special type of digital content that is shared through social media. They have recently emerged as a popular new format of media communication. They are often multimodal, combining text with images and aim to express humor, irony, sarcasm, or sometimes convey hatred and misinformation.

Direct Oral Anticoagulants Versus Vitamin K Antagonists for the Management of Left Ventricular Thrombus After Myocardial Infarction: A Meta-Analysis.

Left ventricular (LV) thrombus formation remains a post-acute myocardial infarction (AMI) complication even in the modern era of early reperfusion. The optimal anticoagulation regimen in this clinical scenario is poorly defined. The present meta-analysis sought to investigate the efficacy and safety profile of direct oral anticoagulants (DOACs) compared with vitamin K antagonists (VKAs) for the management of LV thrombus after AMI.

Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia.

Background: Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensome regimen.

Methods: To test the hypothesis that long-term oxygen therapy used for 24 hours per day does not result in a lower risk of hospitalization or death at 1 year than therapy for 15 hours per day, we conducted a multicenter, registry-based, randomized, controlled trial involving patients who were starting oxygen therapy for chronic, severe hypoxemia at rest.

Fat grafting in breast surgery: a retrospective single-breast centre 6-year experience.

Purpose: In recent years, fat grafting has gained importance as a valuable technique in breast surgery. As a breast center that has embraced this approach, we aimed to investigate the indications and complications of fat grafting.

Methods: In this retrospective study, we examined a total of 263 lipofilling treatments on 121 patients.

Cancer Patients' Perspectives and Requirements of Digital Health Technologies: A Scoping Literature Review.

Digital health technologies have the potential to alleviate the increasing cancer burden. Incorporating patients' perspectives on digital health tools has been identified as a critical determinant for their successful uptake in cancer care. The main objective of this scoping review was to provide an overview of the existing evidence on cancer patients' perspectives and requirements for patient-facing digital health technologies.

Analytical Post-Embedding Immunogold-Electron Microscopy with Direct Gold-Labelled Monoclonal Primary Antibodies against RIBEYE A- and B-Domain Suggests a Refined Model of Synaptic Ribbon Assembly.

Synaptic ribbons are the eponymous specializations of continuously active ribbon synapses. They are primarily composed of the RIBEYE protein that consists of a unique amino-terminal A-domain and carboxy-terminal B-domain that is largely identical to the ubiquitously expressed transcriptional regulator protein CtBP2. Both RIBEYE A-domain and RIBEYE B-domain are essential for the assembly of the synaptic ribbon, as shown by previous analyses of RIBEYE knockout and knockin mice and related investigations.

Hypoglycemic Drugs in Patients with Diabetes Mellitus and Heart Failure: A Narrative Review.

Over the last few years, given the increase in the incidence and prevalence of both type 2 diabetes mellitus (T2DM) and heart failure (HF), it became crucial to develop guidelines for the optimal preventive and treatment strategies for individuals facing these coexisting conditions. In patients aged over 65, HF hospitalization stands out as the predominant reason for hospital admissions, with their prognosis being associated with the presence or absence of T2DM. Historically, certain classes of glucose-lowering drugs, such as thiazolidinediones (rosiglitazone), raised concerns due to an observed increased risk of myocardial infarction (MI) and cardiovascular (CV)-related mortality.

Deleterious intestinal inflammation in neonatal mice treated with TLR2/TLR6 agonists.

By providing innate immune modulatory stimuli, the early-life immune system can be enhanced to increase resistance to infections. Activation of innate cell surface receptors called pattern recognition receptors by Toll-like receptor (TLR) ligands is one promising approach that can help to control infections as described for listeriosis and cryptosporidiosis. In this study, the effect of TLR2/TLR1 and TLR2/TLR6 agonists was compared when injected into neonatal mice.

Correction of the Tuberous Breast with Fat Grafting and Implant: Techniques, Evaluation with BREAST-Q, and Preliminary Results.

Background: The correction of tuberous breast deformity with fat grafting has gained popularity in recent years, but it remains unclear whether this new technique can produce patient satisfaction levels comparable to those achieved with implant-based correction.

Methods: This study aimed to compare patients' satisfaction and quality of life using the BREAST-Q questionnaire after correction of tuberous breast deformity with fat grafting and implants. Twenty-four patients (36 breasts) were included in our study.

[Management of bone metastasis in non-small cell lung cancer].

Lung cancer is notoriously known for its predisposition to metastasize to the bones. Diagnostic tools, including positron emission tomography coupled with computed tomography, offer increased sensitivity in detecting bone infiltration. Management strategies encompass a multidisciplinary approach, including pharmacological pain management, anti-resorptive therapy, radiotherapy, interventional techniques, and surgery.

Correlated Decision Fusion Accompanied with Quality Information on a Multi-Band Pixel Basis for Land Cover Classification.

Decision fusion plays a crucial role in achieving a cohesive and unified outcome by merging diverse perspectives. Within the realm of remote sensing classification, these methodologies become indispensable when synthesizing data from multiple sensors to arrive at conclusive decisions. In our study, we leverage fully Polarimetric Synthetic Aperture Radar (PolSAR) and thermal infrared data to establish distinct decisions for each pixel pertaining to its land cover classification.

Decision Fusion at Pixel Level of Multi-Band Data for Land Cover Classification-A Review.

According to existing signatures for various kinds of land cover coming from different spectral bands, i.e., optical, thermal infrared and PolSAR, it is possible to infer about the land cover type having a single decision from each of the spectral bands.

Beta bursts question the ruling power for brain-computer interfaces.

: Current efforts to build reliable brain-computer interfaces (BCI) span multiple axes from hardware, to software, to more sophisticated experimental protocols, and personalized approaches. However, despite these abundant efforts, there is still room for significant improvement. We argue that a rather overlooked direction lies in linking BCI protocols with recent advances in fundamental neuroscience.

Overbias Photon Emission from Light-Emitting Devices Based on Monolayer Transition Metal Dichalcogenides.

Tunneling light-emitting devices (LEDs) based on transition metal dichalcogenides (TMDs) and other two-dimensional (2D) materials are a new platform for on-chip optoelectronic integration. Some of the physical processes underlying this LED architecture are not fully understood, especially the emission at photon energies higher than the applied electrostatic potential, so-called overbias emission. Here we report overbias emission for potentials that are near half of the optical bandgap energy in TMD-based tunneling LEDs.

The Role of Melatonin to Ameliorate Oxidative Stress in Sperm Cells.

It is widely accepted that oxidative stress (OS) coming from a wide variety of causes has detrimental effects on male fertility. Antioxidants could have a significant role in the treatment of male infertility, and the current systematic review on the role of melatonin to ameliorate OS clearly shows that improvement of semen parameters follows melatonin supplementation. Although melatonin has considerable promise, further studies are needed to clarify its ability to preserve or restore semen quality under stress conditions in varied species.

Diverse beta burst waveform motifs characterize movement-related cortical dynamics.

Classical analyses of induced, frequency-specific neural activity typically average band-limited power over trials. More recently, it has become widely appreciated that in individual trials, beta band activity occurs as transient bursts rather than amplitude-modulated oscillations. Most studies of beta bursts treat them as unitary, and having a stereotyped waveform.

Cutaneous lesions in a COVID-19 patient leading to a surprising diagnosis.

https://bit.ly/400Msre.

Exciton-assisted electron tunnelling in van der Waals heterostructures.

The control of elastic and inelastic electron tunnelling relies on materials with well-defined interfaces. Two-dimensional van der Waals materials are an excellent platform for such studies. Signatures of acoustic phonons and defect states have been observed in current-to-voltage measurements.