Publications by authors named "Papadimitriou-Olivgeris Matthaios"
Background: Fever is common in infective endocarditis (IE), yet little is known about fever duration in such patients. We aim to identify predictors of persistent fever in patients with suspected IE.
Methods: This study was conducted at the Lausanne University Hospital, Switzerland, from January 2014 to June 2023.
Objectives: Duration of treatment for uncomplicated streptococcal bacteraemia is unknown. The study aims to assess clinical outcomes of patients with uncomplicated streptococcal bacteraemia receiving a short course (5-10 days) of antimicrobial treatment compared to those receiving the traditional, longer duration (11-18 days).
Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland and included episodes of uncomplicated streptococcal bacteraemia among adult patients from 2015 to 2023.
Infective Endocarditis (IE) is a complex, life-threatening disease. The aim of the present study was to evaluate the impact of the Endocarditis-Team on management of IE. This observational study conducted at a university hospital (2015‒22), included adult patients with IE.
View Article and Find Full Text PDFArticle Synopsis
- Infective endocarditis is a serious but uncommon condition that can lead to various immune-related issues, such as mixed cryoglobulinemia, which may cause significant organ damage.
- The case presented involves a patient with methicillin-sensitive infective endocarditis who developed cryoglobulinemic vasculitis, showing symptoms consistent with Meltzer's triad and mild kidney problems.
- The study emphasizes the importance of quickly diagnosing the underlying cause of cryoglobulinemic vasculitis to ensure effective treatment and minimize risks of recurrence or additional health complications.
Article Synopsis
- A study involving 302 cases of prosthetic valve endocarditis (PVE) showed a one-year mortality rate of 31%.
- Early-onset PVE (within 6 months of valve surgery) did not result in worse outcomes compared to late-onset PVE, with mortality rates of 21% versus 32% (p=0.126).
- Both early and late-onset categories required similar rates of redo valve surgeries.
Article Synopsis
- Diagnosing infective endocarditis (IE) is complex, and this study compared the effectiveness of the 2015 and 2023 Duke clinical criteria for diagnosing the condition.
- Conducted in two Swiss University Hospitals, researchers analyzed data from 3127 patients suspected of having IE, with 1177 confirmed cases, to assess the agreement between the clinical criteria and expert diagnoses.
- Results showed that the 2023 criteria had a higher sensitivity (69%) compared to the 2015 criteria (59%), although both versions categorized about one-third of episodes as possible IE.
Purpose: To determine predictors of mortality among patients with Pseudomonas aeruginosa bacteraemia.
Methods: Retrospective study.
Setting: This study conducted at the Lausanne University Hospital, Switzerland included adult patients with P.
Background: Bivalent messenger RNA (mRNA) vaccines, designed to combat emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, incorporate ancestral strains and a new variant. Our study assessed the immune response in previously vaccinated individuals of the Swiss HIV Cohort Study (SHCS) and the Swiss Transplant Cohort Study (STCS) following bivalent mRNA vaccination.
Methods: Eligible SHCS and STCS participants received approved bivalent mRNA SARS-CoV-2 vaccines (mRNA-1273.
Evaluation of the HANDOC Score and the 2023 International Society of Cardiovascular Infectious Diseases and European Society of Cardiology Duke Clinical Criteria for the Diagnosis of Infective Endocarditis Among Patients With Streptococcal Bacteremia.
Clin Infect Dis
August 2024
Background: Streptococci are a common cause of infective endocarditis (IE). We aimed to evaluate the performance of the HANDOC score to identify patients at high risk for IE and the Duke clinical criteria of the European Society of Cardiology (ESC; 2015 and 2023 versions) and the 2023 version from the International Society of Cardiovascular Infectious Diseases (ISCVID) in diagnosing IE among patients with streptococcal bacteremia.
Methods: This retrospective study included adult patients with streptococcal bacteremia hospitalized at Lausanne University Hospital.
Objectives: To ascertain whether infective endocarditis (IE) was associated with persistent bacteraemia/candidaemia among patients with suspected IE.
Methods: This study included bacteraemic/candidaemic adult patients with echocardiography and follow-up blood cultures. Persistent bacteraemia/candidaemia was defined as continued positive blood cultures with the same microorganism for 48 h or more after antibiotic treatment initiation.
Background: Streptococcal bacteremia is associated with high mortality. Thia study aims to identify predictors of mortality among patients with streptococcal bacteremia.
Methods: This retrospective study was conducted at the Lausanne University Hospital, Switzerland, and included episodes of streptococcal bacteremia among adult patients from 2015 to 2023.
Purpose: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis.
Methods: Multicenter retrospective study.
Article Synopsis
- This observational study conducted at Lausanne University Hospital from 2014 to 2023 aimed to evaluate the occurrence of infective endocarditis (IE) in patients with bone and joint infections (BJIs) and bacteraemia.
- Out of 384 episodes analyzed, 75% involved native BJI and 29% involved orthopedic implant-associated infection (OIAI), with some patients having both types.
- The study found a prevalence of IE at 27%, specifically 31% in patients with NBJI compared to only 13% in patients with OIAI, highlighting a significant difference between the two groups.
In this retrospective/prospective study, we assessed the role of fundoscopy in 711 episodes with suspected infective endocarditis (IE); 238 (33%) had IE. Ocular embolic events (retinal emboli or chorioretinitis/endophthalmitis) and Roth spots were found in 37 (5%) and 34 (5%) episodes, respectively, but had no impact on IE diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed the diagnostic effectiveness of the Duke-ISCVID 2023 criteria for infective endocarditis (IE) against earlier versions from 2000 and 2015.
- Conducted at two university hospitals between 2014 and 2022, it involved 2132 patients, 1101 of whom were confirmed to have IE.
- Results showed the new criteria improved sensitivity to 84% (up from 70%) but decreased specificity to 60% (down from 74%), suggesting a need for further refinements to balance these diagnostic metrics.
Article Synopsis
- The Duke criteria for diagnosing infective endocarditis were updated in 2023, and this study evaluates their diagnostic accuracy, particularly for patients with Staphylococcus aureus bacteremia (SAB).
- Analyzing data from 1344 SAB episodes, the revised 2023 criteria showed improved sensitivity (81% for Duke-ISCVID and 82% for Duke-ESC) compared to the 2015 version (75%), although specificity decreased from 99% to 96%.
- The study highlights that while spondylodiscitis was more common in patients with SAIE, this trend was not significant when certain criteria were excluded, indicating the need for further research on the new criteria's components.
Multicentric evaluation of a specific intrathecal anti- IgG index as a diagnostic biomarker of neurosyphilis: results from a retro-prospective case-control study.
Sex Transm Infect
February 2024
Background And Objectives: The diagnosis of neurosyphilis (NS) lacks a true 'gold standard', making the diagnosis challenging while consequences of a misdiagnosis are potentially severe. The aim of this study was to evaluate the diagnostic performance of measuring an antibody index (AI) for the intrathecal synthesis of specific anti- () IgG for the diagnosis of NS.
Methods: Specific anti- IgG were measured simultaneously in paired cerebrospinal fluid (CSF)-serum samples collected retrospectively and prospectively between 2007 and 2022, from patients suspected of NS, in Switzerland.
Background: After basic immunization with 2 mRNA SARS-CoV-2 vaccine doses, only a small proportion of patients who are severely immunocompromised generate a sufficient antibody response. Hence, we assessed the additional benefit of a third SARS-CoV-2 vaccine in patients with different levels of immunosuppression.
Methods: In this observational extension of the COVERALL trial (Corona Vaccine Trial Platform), we recruited patients from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study (ie, lung and kidney transplant recipients).
Available data are limited concerning long-term lung function (LF) evolution after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in lung transplant (LT) recipients. The aim of this study is to determine the effect of first SARS-CoV-2 infection on long-term LF in LT recipients. We analyzed spirometry results of LT recipients followed at our institution (March 2020 to July 2022) at 3, 6, and 12 months after first SARS-CoV-2 infection.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2 can affect the gut microbiota and immune responses, leading to varying gastrointestinal symptoms in COVID-19 patients.
- A study included 57 COVID-19 patients and 19 non-COVID-19 ICU patients to analyze changes in gut microbiota through rectal swab samples taken over time.
- Results showed decreased microbiota diversity in COVID-19 patients, with notable differences in bacterial composition compared to non-COVID-19 patients, including increased Bacteroides and decreased butyrate-producing bacteria in ICU patients.
Purpose: Embolic events (EEs) are a common complication of left-side infective endocarditis (IE). The aim of the present study was to identify risk factors for the occurrence of EEs before or after antibiotic treatment instauration among patients with definite or possible IE.
Methods: This retro-prospective study was conducted at the Lausanne University Hospital, Lausanne, Switzerland, from January 2014 to June 2022.
Background: Embolic events (EEs) are a common complication of infective endocarditis (IE) and their presence can impact diagnosis and modify the therapeutic plan. The present study aimed to describe the role of thoracoabdominal imaging, either thoracoabdominal-pelvic Computed Tomography or F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography, on diagnosis and management of patients with suspected IE.
Methods: This study was conducted at a university hospital, from January 2014 to June 2022.
Objectives: To evaluate the role of defervescence within 4 days from antibiotic treatment initiation in ruling out infective endocarditis (IE) among patients suspected of such diagnosis.
Methods: This study was conducted at the Lausanne University Hospital, Switzerland (January 2014 to May 2022). All patients with suspected IE being febrile upon presentation were included.