Synthesis of Quinoline-Based Pt-Sb Complexes with L- or Z-Type Interaction: Ligand-Controlled Redox via Anion Transfer.

A series of Pt-Sb complexes with two or three L-type quinoline side arms were prepared and studied. Two ligands, tri(8-quinolinyl)stibane (SbQ, Q = 8-quinolinyl, ) and 8,8'-(phenylstibanediyl)diquinoline (SbQPh, ), were used to synthesize the Pt-Sb complexes (SbQ)PtCl () and (SbQPh)PtCl (). Chloride abstraction with AgOAc provided the bis-acetate complexes (SbQ)Pt(OAc) () and (SbQPh)Pt(OAc) ().

Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles.

The widespread increase in antibiotic resistance (AR), in an extensive range of microorganisms, demands the development of alternative antimicrobials with novel non-specific low-mutation bacterial targets. Silver nanoparticles (AgNPs) and photosensitizers (PSs) are promising antimicrobial agents with broad-spectrum activity and low tendency for antimicrobial resistance development. Herein, we investigated the light-mediated oxidation of AgNPs for accelerated release of Ag in the antibacterial synergy of PS-AgNP conjugates using protoporphyrin IX (PpIX) as a PS.

Phenyl Sulfones: A Route to a Diverse Family of Trisubstituted Cyclohexenes from Three Independent Nucleophilic Additions.

A novel process is described for the synthesis of di- and trisubstituted cyclohexenes from an arene. These compounds are prepared from three independent nucleophilic addition reactions to a phenyl sulfone (PhSOR; R = Me, Ph, and NCH) dihapto-coordinated to the tungsten complex {WTp(NO)(PMe)}(Tp = trispyrazolylborate). Such a coordination renders the dearomatized aryl ring susceptible to protonation at a carbon ortho to the sulfone group.

Evaluation of Polyhedral Oligomeric Silsesquioxane Porphyrin Derivatives on Photodynamic Therapy.

Polyhedral oligomeric silsesquioxane (POSS) is a promising scaffold to be used as delivery system. POSS can modify the properties of photosensitizers to enhance their efficacy toward photodynamic therapy (PDT). In this work, we designed, synthesized and characterized five different POSS porphyrin () derivatives containing hydrophobic (-) and hydrophilic ( and ) functional groups.