Publications by authors named "Paolo Q Vezzulli"
Introduction: The large-scale approval of anti-amyloid monoclonal antibodies for treating Alzheimer's disease (AD) has raised concerns about their safety due to treatment-emergent amyloid-related imaging abnormalities (ARIA).
Methods: We present two cases of patients diagnosed with mild cognitive impairment due to AD who were enrolled in the GRADUATE I clinical trial. They received subcutaneous gantenerumab every two weeks during the study period.
Article Synopsis
- The AT(N) classification system categorizes patients based on biomarkers linked to Alzheimer’s disease, focusing on amyloid-beta (A), tau pathology (T), and neurodegeneration (N).
- This study investigates a cohort of 429 patients with cognitive decline to see how this classification helps understand Alzheimer's and eligibility for treatments like aducanemab and lecanemab.
- Findings show that while the most common group had all three biomarkers (A+T+N+), there was notable cognitive impairment in this group; however, only 17% of the A+ patients qualified for amyloid-targeting therapies.
Combining semi-quantitative rating and automated brain volumetry in MRI evaluation of patients with probable behavioural variant of fronto-temporal dementia: an added value for clinical practise?
Neuroradiology
June 2023
Purpose: To evaluate the diagnostic value of combined semiquantitative and quantitative assessment of brain atrophy in the diagnostic workup of the behavioural-variant of frontotemporal dementia (bvFTD).
Methods: Three neuroradiologists defined brain atrophy grading and identified atrophy pattern suggestive of bvFTD on 3D-T1 brain MRI of 112 subjects using a semiquantitative rating scale (Kipps'). A quantitative atrophy assessment was performed using two different automated software (Quantib® ND and Icometrix®).
Background: Contrast-enhanced magnetic resonance angiography (CE-MRA) has become a very popular imaging technique in the evaluation of the extracranial vessels pathology, while it is not commonly used to rule out intracranial vascular pathology. On the contrary, 3D time of flight MRA (TOF-MRA) has a solid role in the study of intracranial arterial vessels disease.
Materials And Methods: One hundred and eight patients were consecutively included in the study.