Publications by authors named "Paolo Miraglia"
Article Synopsis
- Immune-mediated glomerulonephritis with a membranous pattern and masked IgG-Kappa deposits (MGMID) is not well understood, especially regarding the nature of its deposits.
- A case study of a 33-year-old woman showed continuous proteinuria and high levels of SSA antibodies, leading to a kidney biopsy that revealed characteristics of MGMID.
- The study provides the first immunohistochemical evidence of Ro52 positivity in kidney tissues, which may contribute to a better understanding of this condition and its association with autoimmune disorders.
Article Synopsis
- Urinary and serological markers are crucial for diagnosing autoimmune diseases, but reliable biomarkers for Behçet's disease (BD) are still missing, complicating patient management.
- A systematic review of 111 studies over 25 years found that most research (99%) focused on serological markers, with very few (2%) exploring urinary biomarkers.
- While studies highlight inflammatory and pro-oxidant changes in BD, a significant gap remains in identifying consistent diagnostic and prognostic markers, indicating the need for continued international research efforts.
Vulnerable subjects, including systemic lupus erythematosus (SLE) patients, have been prioritised to receive anti-SARS-CoV-2 vaccines. Few data about the safety of these vaccines in SLE are available. The aim of our study is to investigate the safety of anti-SARS-CoV-2 vaccines in SLE.
View Article and Find Full Text PDFIntroduction: While renal biopsy remains the gold standard for diagnosing lupus nephritis (LN), the prognostic and diagnostic role of non-invasive biomarkers for LN is currently debated.
Methods: Available studies published in last 5 years (2015-2020) assessing the diagnostic and prognostic value of urinary and/or serological biomarkers in subjects with LN were analyzed in this systematic review.
Results: Eighty-five studies were included (comprehending 13,496 patients with systemic lupus erythematosus [SLE], 8,872 LN, 487 pediatric LN, 3,977 SLE but no LN, 160 pediatric SLE but no LN and 7,679 controls).
Objectives: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with SLE remains unclear and data on clinical manifestations after infection are lacking. The aim of this multicentre study is to describe the effect of SARS-CoV-2 in SLE patients.
Methods: SLE patients referring to four Italian centres were monitored between February 2020 and March 2021.
Background: In this study we aimed to evaluate the usefulness of domain profiling of Beta-2-glycoprotein I(β2GPI)-Domain-1 (D1) antibodies in relation to antiphospholipid antibodies (aPL)-related nephropathy (aPL-N) in patients with biopsy-proven lupus nephritis (LN).
Methods: Of 124 consecutive patients (96 women, mean age 45.5 ± 12.