Publications by authors named "Paolo Masiello"

Article Synopsis
  • The study focuses on a new aggressive treatment method for acute type A aortic dissection using the frozen elephant trunk (FET) technique, which extends repair to the aortic arch and proximal descending thoracic aorta.
  • A total of 66 patients (average age ~63 years, mostly men) underwent emergency surgery between December 2017 and January 2022, with researchers assessing 30-day mortality, in-hospital mortality, and postoperative complications.
  • Results showed a 30-day mortality rate of 10.6% and in-hospital mortality of 13.6%, with key predictors for long-term survival identified, including left ventricular ejection fraction and presence of peripheral vascular disease
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The frozen elephant trunk (FET) technique is an increasingly common procedure to treat complex extensive aortic disease both in elective and emergency setting. In a contemporary era, several prostheses are available to be used by surgeons performing such procedures, merging the advantages of endovascular and conventional surgery and preparing a more useful landing zone for second-stage downstream endovascular or open repair. Thoraflex hybrid (Terumo Aortic, Scotland) is a largely used hybrid vascular device merging a conventional surgical vascular graft made of gelatin-sealed woven polyester graft with a nitinol self-expanding stent graft.

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Objectives: Cardiac support systems are being used increasingly more due to the growing prevalence of heart failure and cardiogenic shock. Reducing cardiac afterload, intracardiac pressure, and flow support are important factors. Extracorporeal membrane oxygenation (ECMO) and intracardiac microaxial pump systems (Impella) as non-permanent MCS (mechanical circulatory support) are being used increasingly.

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Article Synopsis
  • The study evaluates early clinical outcomes of the frozen elephant trunk (FET) technique for treating complex aortic diseases, transitioning from traditional methods.
  • A total of 70 patients were treated, with a 100% technical success rate; however, in-hospital mortality was 14.2% with some occurrences of major strokes and spinal cord injury.
  • The FET technique showed promising results in a real-world context, suggesting good feasibility and outcomes, particularly in neurological complications, but further refinement and protocols for safety are needed.
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Acute type A aortic dissection (ATAAD) is an indisputable emergency with very poor outcomes without surgical treatment. Although the aortic arch is often involved in the aortic dissection, its optimal management during surgical therapy remains uncertain. A conservative tear-oriented approach has traditionally been adopted, limiting the procedure to the ascending aorta (or hemiarch) replacement.

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Difficult diagnosis is due to rarity of the case. TT or TE echocardiography is sufficient to make a correct diagnosis. The risk of embolism or coronary ostia occlusion should guide the decision for surgery.

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We report a unique case of a Starr-Edwards prosthesis (model 6310, cloth covered) implanted in the mitral position by Christian Barnard that was successfully explanted and replaced after 50 years, the longest period free from valve dysfunction ever reported. Reoperation also included replacement of the native aortic valve combined with tricuspid valve annuloplasty. ().

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Article Synopsis
  • Short-term mechanical circulatory support (MCS) devices aid patients in severe cardiac situations, providing hemodynamic stability during high-risk surgeries, heart failure, and other critical conditions.
  • Electrical storm is a dangerous complication in cardiac patients, characterized by multiple episodes of ventricular fibrillation in a day, with a very high mortality rate of 80-90%.
  • The case study details a 38-year-old man with severe coronary artery disease and heart dysfunction who faced an electrical storm after emergency CABG surgery but was successfully treated with a combination of biventricular MCS using extracorporeal life support and devices like Impella CP and ProtekDuo.
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Article Synopsis
  • Type A aortic dissection is a serious surgical emergency with high risks, including a 56% chance of in-hospital mortality without surgery and a 10-20% surgical mortality rate within 30 days.
  • The primary treatment goals involve replacing the damaged ascending aorta and monitoring the distal aortic false lumen, with various surgical techniques depending on the condition of the aortic valve.
  • A case study showcases the successful use of both the Florida sleeve technique and the Vascutek "Thoraflex" hybrid prosthesis to repair the ascending aorta while preserving the native aortic valve and preparing for future interventions.
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Reimplantation of the supra-aortic vessels can be challenging with Thoraflex Hybrid. A device modification made the vessel lengths more appropriate and the position of the neo-vessels in the chest avoided malpositioning and kinking and facilitated sternum closure; this may improve operating times as well as allowing complete and continuous cerebral trivascular perfusion and corrects positioning of the intrathoracic vessels.

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Background: Displacement of Impella 5.0 secondary to patient movement or transportation is a well-known complication. Typically, repositioning of an Impella across the aortic valve is attempted over a guidewire.

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We assessed the predictive accuracy of the Warfarin Pharmacogenetics Consortium (IWPC) algorithm in a prospective cohort of 376 high-risk elderly patients (≥65 years) who required new treatment with warfarin for either medical (non valvular atrial fibrillation) or surgical conditions (heart valve replacement), had ≥1 comorbid conditions, and regularly used ≥2 other drugs. Follow-up visits were performed according to clinical practice and lasted for a maximum of 1 year. Two hundred and eighty-three (75%) patients achieved a stable maintenance dose.

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The authors report the case of an 87-year-old man undergoing transcatheter aortic valve replacement via transfemoral approach who developed a life-threatening complication, i.e., fistulization between the aortic root and the left atrium, which was successfully treated by surgery.

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Spontaneous coronary artery rupture is a rare disorder that may develop early into a sudden death due to the abrupt evolution of the associated cardiac tamponade. In some cases the rupture is contained and a false aneurysm develops with slower evolution of clinical signs. The correct diagnosis of spontaneous coronary artery rupture deserves a high level of suspicion; frequently it may be missed because the time window of its evolution seems to be very short or signs of acute coronary syndrome sometimes can prevail, leading to delays in diagnosis or to misdiagnosis.

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We report a case of type A intramural aortic hematoma (IMH) occurred in a 78 years old female. The clinical scenario (medical history of hypertension, severe substernal chest pain, early diastolic decrescendo murmur as for aortic insufficiency), the laboratory results (no significant troponin level), ECG and transthoracic echocardiography findings (no signs of myocardial ischemia) shifted the initial diagnostic suspicion from acute coronary syndrome to the acute aortic syndrome (AAS) and triggered further imaging tests. Computed tomography revealed an aneurismatic dilatation with thickening of the wall of the ascending aorta without intimal flap.

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We report a case of a huge left atrial myxoma with an unusual clinical presentation characterized by acute pulmonary edema. The possible pathophysiologic mechanism has been discussed.

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Background: the theoretical advantages of mini-invasive cardiac surgery are shorter hospitalisation, better surgical results and costs reduction. In November 1997 we started a non-coronary mini-invasive surgery program using a partial upper median sternotomy. This study has been conceived to retrospectively compare two groups of patients who underwent isolate aortic valve replacement using the conventional and the mini-invasive technique.

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