Publications by authors named "Paolo M Chetta"
Colorectal cancer (CRC) is one of the most common cancers worldwide and demands more effective treatments. We sought to identify tumor selective CRC antigens and their therapeutic potential for cytotoxic T-cell targeting by transcriptomic and immunohistochemical analysis. LY6G6D was identified as a tumor selectively expressed CRC antigen, mainly in the microsatellite stable (MSS) subtype.
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- The androgen receptor (AR) is a major driver of prostate cancer, and despite new therapies, patients with metastatic disease often have poor outcomes, highlighting the need for deeper understanding of AR-related processes in cancer cells.
- This study uses mass spectrometry to show that increased fatty acyl chain length in phospholipids is a key change in lipid metabolism influenced by AR, particularly focusing on the enzyme ELOVL5 that elongates fatty acids.
- Results indicate that ELOVL5 is crucial for prostate cancer cell proliferation and metastasis, with its depletion causing harmful mitochondrial effects, while supplementation with a fatty acid product of ELOVL5 counteracts these effects, suggesting targeted therapies could focus on lipid elongation pathways.
Context: Ductal adenocarcinoma (DAC) is relatively rare, but is nonetheless the second most common subtype of prostate cancer. First described in 1967, opinion is still divided regarding its biology, prognosis, and outcome.
Objectives: To systematically interrogate the literature to clarify the epidemiology, diagnosis, management, progression, and survival statistics of DAC.