Publications by authors named "Paolo E Di Simone"
Eur J Immunol
September 2024
Article Synopsis
- - The study investigates the factors that predict the development of inhibitors (neutralizing antibodies) against factor VIII (FVIII) in hemophilia A patients, highlighting that both genetic and environmental influences are not fully understood.
- - Researchers used HA and wild-type (WT) mice to examine immune responses after exposure to FVIII and ovalbumin (OVA), assessing antibody levels and immune cell dynamics over nine weeks.
- - Findings revealed that humoral responses to FVIII were similar between HA and WT groups, but HA T cells showed heightened sensitivity and increased memory T-cell activation and proliferation, indicating a distinct immune response in hemophilia A.
