Publications by authors named "Paolo Castillo"
Article Synopsis
- - The study aimed to understand MRI imaging patterns in breast cancer patients undergoing neoadjuvant immunotherapy, particularly focusing on responses to various combinations of chemotherapy and immunotherapy in the I-SPY2 clinical trial.
- - Out of 43 patients analyzed, 44.4% receiving the chemo-immunotherapy experienced increased lymphadenopathy in the first 12 weeks, significantly higher compared to just 6.3% in the control group, with most cases linked to the SD-101 and pembrolizumab treatment.
- - Despite observing increased lymphadenopathy in some patients, this was not associated with a higher incidence of positive lymph nodes at surgery, even as breast tumor sizes decreased over time.
Objectives: We describe the development and implementation of a system for monitoring patient-reported adverse events and quality of life using electronic Patient Reported Outcome (ePRO) instruments in the I-SPY2 Trial, a phase II clinical trial for locally advanced breast cancer. We describe the administration of technological, workflow, and behavior change interventions and their associated impact on questionnaire completion.
Materials And Methods: Using the OpenClinica electronic data capture system, we developed rules-based logic to build automated ePRO surveys, customized to the I-SPY2 treatment schedule.