Publications by authors named "Paolo Bonomo"
Article Synopsis
- The European Society of Cardiology (ESC) and European Atherosclerosis Society (EAS) have introduced stricter LDL-C targets for managing dyslipidemias, especially for very high-risk (VHR) patients compared to previous guidelines from 2016.
- A study involving over 5,000 patients with established atherosclerotic cardiovascular disease assessed the current use of cholesterol-lowering treatments and the achievement of LDL-C goals set by the latest ESC guidelines.
- Results showed that only 3.2% of VHR patients met the new LDL-C target of <55 mg/dl, indicating poor lipid management and a low eligibility rate for advanced treatments like PCSK9 inhibitors.
Article Synopsis
- Researchers studied 164 patients with LMNA gene mutations across 13 clinical centers in Italy from 2000 to 2018 to understand the natural progression of associated neuromuscular and cardiac diseases.* -
- Results showed that neuromuscular symptoms appeared about 11 years before cardiac issues, with 90% of patients eventually developing heart disease and notable occurrences of arrhythmias and other serious complications.* -
- The study highlights that patients often exhibit significant neurologic symptoms by their 30s, leading to severe and potentially life-threatening conditions as they age.*
Article Synopsis
- The study highlights the gap in knowledge regarding rotavirus circulation in adults and the general population in Italy, despite the existence of a molecular surveillance network for children.
- During 2010-2011, researchers analyzed 285 sewage samples from four cities, detecting rotavirus in 60.4% of them, with a variety of genotypes identified, notably G1 and P[8].
- The findings indicate that certain genotypes, particularly G2, G9, and P[4], were more prevalent in wastewaters than in hospitalized pediatric patients, suggesting these strains might circulate widely in the general population or persist longer in the environment.
Hospital-based surveillance of acute gastroenteritis caused by rotavirus has produced ample knowledge on the infection in children, whereas little is known on rotavirus infection among adults. The Italian surveillance program RotaNet-Italia collected 1,595 samples from patients admitted to hospital with gastroenteritis in 2012. All patients presented with vomiting, diarrhea, fever, and/or abdominal pain.
View Article and Find Full Text PDFThis study evaluated the presence and seasonal distribution of polio and other enteroviruses in four wastewater treatment plants in three cities in Italy, using different treatment systems. Detection of enteroviruses was carried out by virus isolation in cell cultures after concentration of water samples collected at both inlet and outlet of the treatment plants, following the methods described in the WHO guidelines. Viral serotypes isolated before and after water treatment were compared.
View Article and Find Full Text PDFHuman sapoviruses were identified in 15 (12.4 %) of 121 inlet sewage samples collected from wastewater treatment plants in Naples and Palermo, Italy, in 2011. All strains, except one GI.
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