Publications by authors named "Paola X De la Iglesia"
Article Synopsis
- Splenosis is the abnormal growth of splenic tissue outside of the spleen, typically following trauma or surgery, and it usually appears on highly vascular areas like the omentum or mesentery.
- This condition is characterized by growth in a sessile (stemless) form, relying on nearby blood vessels for its supply.
- The case discussed involves a 14-year-old boy with a rare occurrence of intestinal splenosis causing endoluminal growth, leading to a small bowel intussusception that required surgery.
At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo. Sperm contain a large dense-core secretory granule (the acrosome) whose contents are secreted by regulated exocytosis at fertilization. Minutes after the arrival of the triggering signal, the acrosomal and plasma membranes dock at multiple sites and fusion pores open at the contact points.
View Article and Find Full Text PDFExocytosis of mammalian sperm dense-core secretory granule relies on the same fusion molecules as all other secretory cells; one such molecule is the small GTPase Rab3A. Here, we report an in-depth biochemical characterization of the role of Rab3A in secretion by scrutinizing the exocytotic response of streptolysin O-permeabilized human sperm to the acute application of a number of Rab3A-containing constructs and correlating the findings with those gathered with the endogenous protein. Full length, geranylgeranylated, and active Rab3A elicited human sperm exocytosis per se.
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