Publications by authors named "Paola Vitali"
Article Synopsis
- The study investigates how stereotactic body radiation therapy (SBRT) affects lymph-nodal prostate cancer oligometastases, focusing on the different treatment outcomes between pelvic and para-aortic lymph nodes.
- A total of 240 lymph-nodal oligometastases from 164 patients were analyzed, revealing a median progression-free survival (PFS) of 20 months for pelvic cases versus 11 months for para-aortic cases, although this difference wasn’t significant in further analyses.
- The findings indicate that while patients with para-aortic disease may have comparable PFS to those with pelvic disease, both groups demonstrate high local control rates, suggesting SBRT is beneficial for treating para-aortic metastases.
Article Synopsis
- Researchers aimed to create a survival prediction model for patients with stage I Non-Small Cell Lung Cancer (NSCLC) receiving stereotactic body radiation therapy (SBRT), as no such models currently exist.
- They collected clinical data from patients across three institutions to develop and validate this model using Cox regression and artificial neural networks.
- The model identified two prognostic groups based on survival outcomes, showing promise for clinically stratifying SBRT patients, with recommendations for further validation.
Background: Stereotactic radiotherapy (SRT) and Proton therapy (PT) are both options in the management of liver lesions. Limited clinical-dosimetric comparison are available. Moreover, dose-constraint routinely used in liver PT and SRT considers only the liver spared, while optimization strategies to limit the liver damaged are poorly reported.
View Article and Find Full Text PDFIntroduction: The standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC) is chemoradiotherapy (CRT) followed by consolidation durvalumab as shown in the PACIFIC trial. The purpose of this study is to evaluate clinical outcomes and toxicities regarding the use of durvalumab in a real clinical scenario.
Methods: A single-center retrospective study was conducted on patients with a diagnosis of unresectable stage III NSCLC who underwent radical CRT followed or not by durvalumab.
Introduction: Radiochemotherapy (RCHT) for the treatment of anal squamous cell carcinoma (ASCC) has evolved dramatically, also thanks to intensity-modulated RT (IMRT) and 3D image guidance (3D IGRT). Despite most patients presenting fair outcomes, unmet needs still exist. Predictors of poor tumor response are lacking; acute toxicity remains challenging; and local relapse remains the main pattern of failure.
View Article and Find Full Text PDFPurpose: To describe the pattern of recurrence in resected pN1 non-small cell lung cancer (NSCLC) and to identify factors predicting an increased risk of locoregional recurrence (LR) or distant metastasis (DM) to define a selected population who may benefit from postoperative radiotherapy (PORT).
Methods: 285 patients with resected pN1 NSCLC were identified. Patients with positive surgical margins, undergoing neoadjuvant treatment or PORT, were excluded.
One-hundred patients treated with curative radiotherapy (RT) ± chemotherapy (CT) for an anal canal carcinoma (T1-4N0-3M0) were retrospectively analyzed. Five- and 10-year local control (LC) rates were 73% and 67%, respectively. Acute and late G3-G4 toxicity rates were 32% and 12%, respectively.
View Article and Find Full Text PDFPurpose: To validate, in the context of adaptive radiotherapy, three commercial software solutions for atlas-based segmentation.
Methods And Materials: Fifteen patients, five for each group, with cancer of the Head&Neck, pleura, and prostate were enrolled in the study. In addition to the treatment planning CT (pCT) images, one replanning CT (rCT) image set was acquired for each patient during the RT course.
Purpose: To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol.
Methods: A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patients were divided in the four groups: gestational hypertension (113 patients); mild preeclampsia (77 patients); severe preeclampsia (31 patients); HELLP syndrome (21 patients).
Background And Purpose: To evaluate survival, locoregional control and toxicity in a series of 56 mesothelioma patients treated from May 2005 to May 2010 with post-operative radiotherapy after extrapleural pneumonectomy (EPP) in three Italian Institutions (Brescia, Florence, and Modena).
Material And Methods: Fifty-six patients treated with adjuvant radiotherapy (RT) after EPP were analyzed. Four patients were treated with 3DCRT, 50 with IMRT and two with helical tomotherapy.
The aim of the study was to investigate platelet nitric oxide (NO) pathways in women with Gestational Hypertension (GH), Preeclampsia (PE) and Controls. Platelet NO(x) and peroxynitrite (ONOO(-)) levels, inducible (iNOS) and endothelial nitric oxide synthase (eNOS) and Nitrotyrosine expression (N-Tyr) in 30 women with GH, 30 with PE and 30 healthy pregnant controls, age, parity and gestational age-matched, were assessed. Platelet NO(x) and ONOO(-) levels were significantly higher in GH and PE vs.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to explore how platelet nitric oxide (NO) metabolism is involved in spontaneous miscarriage (SM) and recurrent spontaneous miscarriage (RSM) in comparison to healthy pregnant women.
- It used a retrospective case-control approach, involving 30 women with SM, 9 with RSM, and 30 matched healthy controls, focusing on measuring levels of NO, peroxynitrite, and various forms of nitric oxide synthase.
- Results indicated elevated levels of NO and associated markers in women with SM and RSM, suggesting that altered NO metabolism may play a crucial role in miscarriages and could be a target for future treatment strategies to reduce miscarriage-related issues.