Publications by authors named "Paola Oquist"
NMR investigations of glycan conformation, dynamics, and interactions.
Prog Nucl Magn Reson Spectrosc
December 2024
Article Synopsis
- * NMR (Nuclear Magnetic Resonance) is essential for understanding glycan properties due to their flexible nature, allowing researchers to analyze their geometry, dynamics, and internal motions.
- * The review highlights the use of NMR to explore various natural glycans and their synthetic analogues, focusing on how these techniques can help understand glycan interactions with proteins, enhancing our knowledge for therapeutic applications.
Ebola virus (EBOV) is a single-strand RNA virus belonging to the family, which has been associated to most Ebola virus disease outbreaks to date, including the West African and the North Kivu epidemics between 2013 and 2022. This unprecedented health emergency prompted the search for effective medical countermeasures. Following up on the carbazole hit identified in our previous studies, we synthetized a new series of compounds, which demonstrated to prevent EBOV infection in cells by acting as virus entry inhibitors.
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