Thymus-Derived CD4CD8 Cells Reside in Mediastinal Adipose Tissue and the Aortic Arch.

Double-positive CD4CD8αβ (DP) cells are thought to reside as T cell progenitors exclusively within the thymus. We recently discovered an unexpected CD4 and CD8αβ immune cell population in healthy and atherosclerotic mice by single-cell RNA sequencing. Transcriptomically, these cells resembled thymic DPs.