Publications by authors named "Paola M R Parisi"
Article Synopsis
- Researchers have rediscovered a previously forgotten phenotype of Alzheimer's disease (AD) called presbyophrenia, now referred to as the confabulation-misidentification phenotype.
- This phenotype is characterized by symptoms similar to Korsakoff syndrome, including severe memory loss, disorientation, confabulation, and additional cognitive impairments.
- The article summarizes findings about this phenotype and highlights areas that require further investigation to confirm its status as a variant of Alzheimer's disease.
Background: Alzheimer's disease (AD) is clinically heterogeneous, including the classical-amnesic (CA-) phenotype and some variants.
Objective: We aim to describe a further presentation we (re)named confabulation-misidentification (CM-) phenotype.
Methods: We performed a retrospective longitudinal case-series study of 17 AD outpatients with the possible CM-phenotype (CM-ADs).
Signs and symptoms method in neuropsychology: A standardized observational examination of cognitive functions can be effective in detecting mild cognitive impairment.
Neuropsychology
October 2023
Objective: The present study aimed at investigating the sensitivity and specificity of the NeuroPsychological Examination (NPE), a systematic collection of cognitive signs and symptoms based on the observation of the patient's behavior during a clinical interview, in detecting Mild Cognitive Impairment (MCI).
Method: 475 participants, 208 suffering from MCI, 188 suffering from dementia and 79 subjective cognitive decline (SCD), have been assessed using NPE for the presence of signs and symptoms of cognitive impairment. Receiver operating characteristic (ROC) curve analysis and the Youden's test were used to determine the more appropriate cutoff points for the number of neuropsychological signs at the NPE that enabled to discriminate SCD from MCI, SCD from dementia and MCI from dementia.