Publications by authors named "Paola Finocchieto"

Article Synopsis
  • Neutrophils in severe COVID-19 show increased activation markers and produce inflammatory signals like CXCL8 and CCL2.
  • Their activity correlates with markers of tissue damage, such as lactate dehydrogenase and D-dimer levels in the blood.
  • Immune complexes, particularly involving specific antibodies, may enhance neutrophil inflammation, potentially worsening COVID-19 severity.
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SPARC, also known as osteonectin and BM-40, is a matricellular protein with a number of biological functions. Hepatic SPARC expression is induced in response to thioacetamide, bile-duct ligation, and acute injuries such as concanavalin A and lipopolysacharide (LPS)/D-galactosamine. We have previously demonstrated that the therapeutic inhibition of SPARC or SPARC gene deletion protected mice against liver injury.

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For many years, mitochondrial respiration was thought to follow an "all or nothing" paradigm supporting the notion that in the normal O2 concentration range, respiration is mainly controlled by tissue demands. However, nitric oxide produced by cytosol or mitochondrial nitric oxide synthases adapts respiration to different physiologic conditions and increases the mitochondrial production of O2 active species that contributes to NO clearance. Because mitochondrial NO utilization is sensitive to environmental or hormonal modulation, and because diffusible active species, like H2O2, are able to regulate genes related to proliferation, quiescence, and death, we surmised that the two mechanisms converge to elicit the different responses in cell physiology.

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