Publications by authors named "Paola Cirrincione"
Polycarbophil (POL), a polyacrylic acid cross-linked with divinyl glycol, is widely used in semisolid and solid dosage forms. When undergoing a thermal treatment in the range 120-160 °C, POL shows interesting morphological modifications, related to changes in physical properties, such as swelling of the powder granules, or hardening and matrix formation if included in the composition of a tablet. Thermal analysis conducted on POL highlighted a thermal event (Z) that can be correlated both to the shrinking of the powder granules and to the matrix formation in compacted POL powder.
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- An innovative matrix composed of polycarbophil and ethylcellulose was developed to control the release of diltiazem hydrochloride through thermal treatment.
- The matrix releases about 72% of the drug over 25 hours at a constant rate, using an anomalous transport mechanism, and maintains its properties even with 50% drug loading.
- A mathematical model was created using a 3-component mixture design to optimize the matrix formulation, revealing a specific POL:EC ratio (1:1-2:3) for achieving the desired release rate over an extended stability period of at least 2.7 years at room temperature.