Publications by authors named "Paola Amaral Campos"
Article Synopsis
- The study investigates antibiotic prescribing practices in adult ICUs across Brazil to address the issues related to multidrug-resistant infections in low- and middle-income countries.* -
- A survey conducted in 58 ICUs found that 63.9% of the 620 patients were on antibiotics, with 72.3% receiving empirical treatment, indicating a lack of reliance on microbiological testing.* -
- The findings show a high incidence of pneumonia and bloodstream infections, with significant variations in antibiotic use between teaching and non-teaching hospitals, raising concerns about healthcare-associated infections.*
This study used whole-genome sequencing (WGS) and PFGE to analysis KPC-2-producing Klebsiella pneumoniae strains from clinical specimens collected in Brazilian hospitals. The study identifies the emergence of a novel small IncX3 plasmid (pKPB11), 12,757-bp in length, in a high-risk K. pneumoniae ST11/CG258 lineage, a successful clonal group in Brazil, carrying the bla gene on a non-Tn4401 genetic element (NTE-Ic).
View Article and Find Full Text PDFBackground: Carbapenem-resistant Acinetobacter baumannii (CR-Ab) has become a worrying health care problem, mainly in developing countries, such as Brazil. The objective was to investigate the prevalence and prognostic factors for CR-Ab infections at a Brazilian university hospital and examine the impact of inappropriate antimicrobial therapy on patient outcome.
Methods: A retrospective study on hospitalized patients with CR-Ab infections was carried out from January 2013 to December 2017.
The emergence of infections associated to new antimicrobial resistance in Acinetobacter baumannii (Ab) genotypes represents a major challenge. In this context, this study aimed to determine the diversity of resistance mechanisms and investigate clonal dissemination and predominant sequence types (STs) in multidrug-resistant Ab strains of clinical (tracheal aspirate, n = 17) and environmental (surface, n = 6) origins. Additionally, the major clones found in clinical (A) and environmental (H) strains had their complete genomes sequenced.
View Article and Find Full Text PDFCarbapenemase-producing organisms are pandemic and a significant threat to public health. We investigated the clonal relatedness of colistin-resistant strains producing KPC-type carbapenemase (KPC-KP) causing subsequent infections or colonization. Moreover, we aimed to gain insight into the ability of biofilm production in strains producing carbapenemase.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the ability of Acinetobacter baumannii and Klebsiella pneumoniae strains, from a Brazilian hospital, to form biofilms, focusing on their genetic variations and resistance profiles.
- Researchers conducted adhesion assays and quantitative evaluations of biofilm production in 10 strains of each species and found that A. baumannii showed better attachment compared to K. pneumoniae, with no isolates classified as strong biofilm producers.
- Results indicated that biofilm formation varies among strains and is not linked to clonal types or multidrug resistance, though more virulent K. pneumoniae strains tended to produce more biofilms.