The multifaceted nature of Egyptian mummification: Paleoradiological insights into child mummies.

In accordance with ancient Egyptian beliefs, the preservation of the body after death was an important prerequisite for the continued existence of the deceased in the afterlife. This involved application of various physical interventions and magical rituals to the corpse. Computed tomography (CT), as the gold-standard technology in the field of paleoradiology, enables deeper insights into details of artificial body preservation.

Renal Arteriosclerosis in kidney biopsies associated with higher 10-year atherosclerotic cardiovascular disease in lupus nephritis.

Objective: Patients with lupus nephritis (LN), including those below age 50, face significantly higher risk of atherosclerotic cardiovascular disease (ASCVD) vs. peers. This highlights the need for identifying specific ASCVD risk factors in LN.

Visual behavior of racing bike cyclists in multi-tasking situations.

Distracted biking can have serious repercussions for the rider such as accidents. The purpose of the present experiment was to determine the effect of visually monitoring two parameters, the cadence, and the heart rate on a bike computer fixed on a racing bike, and simultaneously detect hazardous traffic situations. Individuals (n = 20) were instructed to ride a racing bike that was fitted onto a roller trainer.

Traumatic fractures in an early 19th century museum skeleton suggest the homicide of an old Munich character: the history of "Finessensepperl" (Finesse Joseph).

The well preserved skeleton of Joseph Huber, a very well-known historical character of the 19th century Munich, also nicknamed "Finessen-Sepperl", is the starting point of the reconstruction of life and death of this historical individual. He was known as a postilion d´amour (love's messenger) of the Royal Bavarian capital with numerous comments and anecdotes and a few biographical sketches that indicate he remained well until the last few years of his life where requests for his duties lessened. The skeleton shows a small-sized male individual with almost complete loss of teeth, but otherwise very well-mineralized bone, having suffered from three episodes of trauma - an old-healed incomplete femoral neck fracture leading to severe osteoarthrosis, a clavicle fracture of the medial third with a few weeks old callus formation, and fresh serial rib fractures along with severe skull trauma with fractures of the os temporale and petrosum, presumably leading to intracranial bleeding and finally death.

Preservation of the heart in ancient Egyptian mummies: A computed tomography investigation with focus on the myocardium.

The ancient Egyptians considered the heart to be the most important organ. The belief that the heart remained in the body is widespread in the archeological and paleopathological literature. The purpose of this study was to perform an overview of the preserved intrathoracic structures and thoracic and abdominal cavity filling, and to determine the prevalence and computed tomography (CT) characteristics of the myocardium in the preserved hearts of ancient Egyptian mummies.

Dual-Task and Single-Task Practice Does Not Influence the Attentional Demands of Movement Sequence Representations.

This study examined the attentional demands of movement sequence representations at different temporal points after single- or dual-task practice. The visual-spatial representation encodes the movement based on visual-spatial coordinates such as the target locations. The motor representation encodes the movement in motor coordinates including joint angles and muscle activation patterns.

Across-task binding: The development of a representation in learning a continuous movement sequence.

Across-task binding is defined as the stimulus/response of one task being linked to the response of another task. The purpose of the present experiment was to determine across-task binding in a continuous movement sequence task with an auditory task of high and low pitch tones and the development of a movement sequence representation. According to the two systems theory of sequence learning, we expected that the developed representation in the across-task binding context relies on the multi-dimensional system rather than on the unidimensional system which is restricted to a set of modules where each module processed information along one task/dimension.

Dyad motor learning in a wrist-robotic environment: Learning together is better than learning alone.

Objective: Dyad motor practice is characterized by two learners alternating between physical and observational practice, which can lead to better motor outcomes and reduce practice time compared to physical practice alone. Robot-assisted therapy has become an established neurorehabilitation tool but is limited by high therapy cost and access. Implementing dyad practice in robot-assisted rehabilitation has the potential to improve therapeutic outcomes and/or to achieve them faster.

Decreased platelet activation predicts hepatic decompensation and mortality in patients with cirrhosis.

Background And Aims: Patients with cirrhosis show alterations in primary hemostasis, yet prognostic implications of changes in platelet activation remain controversial, and assay validity is often limited by thrombocytopenia. We aimed to study the prognostic role of platelet activation in cirrhosis, focusing on bleeding/thromboembolic events, decompensation, and mortality.

Approach And Results: We prospectively included 107 patients with cirrhosis undergoing a same-day hepatic venous pressure gradient (HVPG) and platelet activation measurement.

SV channel VfTPC1 is a hyperexcitable variant of plant vacuole Two Pore Channels.

To fire action-potential-like electrical signals, the vacuole membrane requires the two-pore channel TPC1, formerly called SV channel. The TPC1/SV channel functions as a depolarization-stimulated, non-selective cation channel that is inhibited by luminal Ca. In our search for species-dependent functional TPC1 channel variants with different luminal Ca sensitivity, we found in total three acidic residues present in Ca sensor sites 2 and 3 of the Ca-sensitive AtTPC1 channel from that were neutral in its ortholog and also in those of many other Fabaceae.

Motor Transfer and Proactive Interference in Cycling With a Noncircular Chainring.

Athletes must transfer their performance when changing equipment due to innovative developments in sports technology. This kind of transfer has received only moderate attention. The aim of this study was to examine whether a mechanical change in sports equipment disturbs an athlete's performance and affects biomechanical and neurophysiological parameters.

Postmortem changes in ancient Egyptian child mummies: Possible pitfalls on CT images.

Objective: To identify and interpret computed tomography (CT) findings of postmortem changes in ancient Egyptian child mummies.

Materials: Whole-body CT examinations of 21 ancient Egyptian child mummies from German (n = 18), Italian (n = 1), and Swiss museums (n = 2).

Methods: Conspicuous CT findings from prior evaluations with various research questions that were assessed as postmortem changes were classified, and special cases were illustrated and discussed.

Platelet Function Decreases with Increasing Severity of Liver Cirrhosis and Portal Hypertension-A Prospective Study.

Background:  Cirrhotic patients display an increased risk for both bleeding and thrombosis. We investigated platelet activation across Child-Pugh stages (CPSs) and portal hypertension (PH) severity.

Material And Methods:  A total of 110 cirrhotic patients were prospectively included.

Visual behavior and road traffic hazard situations when using a bike computer on a racing bike: An eye movement study.

Bike computers are an important equipment, especially on race bikes where athletes can monitor output parameters. The purpose of the present experiment was to determine the effect of visually monitoring the cadence of a bike computer and to perceive hazard traffic situations in a virtual environment. In a within subject-design individuals (N = 21) were instructed to perform the riding task in two single-task conditions (only watching the traffic at the video with occluded or without occluded bike computer), two dual-task conditions (monitoring the cadence of 70 RPM or 90 RPM and observing the traffic) and one control condition (no instructions).

Associations between upper quarter Y-balance test performance and sport-related injuries in adolescent handball players.

Handball players are at a high risk of suffering a sport-related injury. Recent studies in various adult populations (e.g.

Growth Differentiation Factor 15 Is Associated with Platelet Reactivity in Patients with Acute Coronary Syndrome.

Bleeding events in patients with acute coronary syndrome (ACS) are a risk factor for adverse outcomes, including mortality. We investigated the association of growth differentiation factor (GDF)-15, an established predictor of bleeding complications, with on-treatment platelet reactivity in ACS patients undergoing coronary stenting receiving prasugrel or ticagrelor. Platelet aggregation was measured by multiple electrode aggregometry (MEA) in response to adenosine diphosphate (ADP), arachidonic acid (AA), thrombin receptor-activating peptide (TRAP, a protease-activated receptor-1 (PAR-1) agonist), AYPGKF (a PAR-4 agonist) and collagen (COL).

Microvascular Thrombosis as a Critical Factor in Severe COVID-19.

Platelet-endothelial interactions have a critical role in microcirculatory function, which maintains tissue homeostasis. The subtle equilibrium between platelets and the vessel wall is disturbed by the coronavirus disease 2019 (COVID-19), which affects all three components of Virchow's triad (endothelial injury, stasis and a hypercoagulable state). Endotheliitis, vasculitis, glycocalyx degradation, alterations in blood flow and viscosity, neutrophil extracellular trap formation and microparticle shedding are only few pathomechanisms contributing to endothelial damage and microthrombosis resulting in capillary plugging and tissue ischemia.

Impact of ABO Blood Group on Thromboembolic and Bleeding Complications in Patients with Left Ventricular Assist Devices.

Background:  The ABO blood group system is linked to hemostasis via its relationship with von Willebrand factor (VWF) and factor VIII (FVIII). In the current study, we investigated the association of the ABO system with clinical outcomes as well as VWF and platelet function in patients with left ventricular assist devices (LVADs).

Methods:  Bleeding and thromboembolic complications were assessed in 111 patients during 1 year after LVAD implantation.

Effects of age simulation and age on motor sequence learning: Interaction of age-related cognitive and motor decline.

Aging is known to lead to decrements in sensory and cognitive functioning and motor performance. The purpose of the present experiment was twofold: a) We assessed the influence of wearing an age simulation suit on motor sequence learning, cognitive speed tasks and far visual acuity in healthy, younger adults. b) We evaluated the interaction of cognitive aging and declining motor sequence learning in older adults.