Publications by authors named "Panxue Zhang"
Iron deficiency anemia (IDA) caused by micronutrient iron deficiency has attracted global attention due to its adverse health effects. The regulation of iron uptake and metabolism is finely controlled by various transporters and hormones in the body. Dietary iron intake and regulation are essential in maintaining human health and iron requirements.
View Article and Find Full Text PDFIron deficiency anemia (IDA) is a serious threat to the health of humans around the world. () is considered as an excellent source of iron due to its abundant iron-binding protein hemoglobin. This study aimed to investigate the effects of hemoglobin from on the gut microbiota and iron bioavailability in IDA mice.
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- Iron deficiency anemia (IDA) is a prevalent nutritional issue worldwide, and this study investigates the effects of hemoglobin derived from Tegillarca granosa (T. granosa) on IDA in mice.
- After a 4-week treatment with varying doses of hemoglobin, results showed that a dose of 2.0 mg iron/kg was more effective in improving blood parameters and correcting organ damage compared to traditional iron supplements like FeSO.
- The research also highlighted how hemoglobin supplementation restored important iron-related indicators in the serum, suggesting that T. granosa hemoglobin could be a promising alternative for treating IDA.
Article Synopsis
- The study investigated the iron absorption capabilities of hemoglobin and ferritin from the shellfish Tegillarca granosa, which showed promising results compared to human proteins.
- The research found that hemoglobin had higher digestibility and iron release, offering 26.10-39.31% more iron absorption than ferritin, largely influenced by hepcidin levels.
- Additionally, both hemoglobin and ferritin demonstrated a lower risk of oxidative stress compared to traditional iron supplements, highlighting their potential as safe and effective iron sources.
Iron deficiency anemia (IDA) is a common micronutrient deficiency. Tegillarca granosa (T. granosa) is a good source of iron due to its high content of hemoglobin.
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