Identification of NIBAN2-Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis.

Osteoporosis is characterized by excessive bone resorption and/or defects in bone formation. Identification of factors promoting osteoblast differentiation may provide potential targets for osteoporosis therapy. Through integral analyses of multiple datasets, NIBAN2 is found to be tightly associated with bone formation and osteoporosis.

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation.

Proteotoxicity induced by misfolded or aggregated proteins causes progressive neuronal damage. The endoplasmic reticulum (ER) protein quality control (ERQC) pathways are responsible for mitigating the accumulation of these misfolded or aggregated proteins, thus reducing proteotoxicity. Enhancing ERQC pathways is a promising strategy for treating neurodegenerative diseases.

Competing Risk Analysis for Diabetes Mellitus Mortality in Bladder Cancer Patients: A Population-based Study.

Background: Historically, there has been a lack of focus on the mortality rates of individuals with both diabetes and Bladder Bancer (BC). Our study aimed to identify the risk factors associated with death from Diabetes Mellitus (DM) in BC patients.

Methods: Data was gathered from the SEER database on individuals who were diagnosed with BC between the years 2000 and 2017.

Clinical Significance of RBM15 in Gastric Cancer: A Multi-Database Validation.

Background: Gastric Cancer (GC) represents a highly prevalent and aggressive form of malignancy. Recent scholarly endeavors have implicated the RNA binding motif protein 15 (RBM15) gene in the onset and progression of cancer. The present study was designed to delve into the expression profile of RBM15 in GC, assess its prognostic significance, and explore its potential as a viable therapeutic target.

HOXC-AS1: A Key Biomarker for Prognosis and Immunotherapy in Lung Adenocarcinoma.

Background: The function of HOXC antisense RNA 1 (HOXC-AS1) in lung adenocarcinoma (LUAD) remains largely unexplored.

Objective: The objective of this research was to examine the relationship between HOXC-AS1 levels and LUAD through both bioinformatics analysis and experimental validation.

Methods: We employed statistical methods and bioinformatics to evaluate the correlation between HOXC-AS1 expression and various clinical features, survival predictors, regulatory mechanisms, and immune cell infiltration in LUAD.

Semiconducting Open-Shell Radicals for Precise Tumor Activatable Phototheranostics.

Semiconducting open-shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class of semiconducting perylene diimide (PDI), designated as PDI(Br) with various numbers of bromine (Br) atoms modified on PDI's bay/ortho positions is reported. PDI(Br) is demonstrated to transform into a radical anion, [PDI(Br)], in a reducing solution, with a typical g-value of 2.

Realizing Intrinsically Ultralow and Glass-Like Thermal Transport via Chemical Bonding Engineering.

Crystals exhibiting glass-like and low lattice thermal conductivity ( ) are not only scientifically intriguing but also practically valuable in various applications, including thermal barrier coatings, thermoelectric energy conversion, and thermal management. However, such unusual are typically observed only in compounds containing heavy elements, with large unit cells, or at high temperatures. In this study, chemical bonding principles are utilized to weaken the Ag-Ag bonds and enhance lattice anharmonicity.

ISM1 regulates white adipose tissue remodelling by dampening adipocyte differentiation and enhancing inflammation.

Aims: Isthmin-1 (ISM1), a secretory protein predominantly derived from brown adipose tissue, enhances glucose tolerance and attenuates hepatic steatosis. However, its potential involvement in white adipose tissue remodelling remains elusive, which profoundly impacts adipocyte insulin sensitivity and consequently alters systemic metabolic homeostasis.

Materials And Methods: ISM1 expression profiles in human and mouse were systematically characterized using Tabula Sapiens.

Prognostic Value of the Metabolic Response on Serial F-FDG PET/CT in Pancreatic Cancer.

Background/aims: The prognostic value of serial F-fluorodeoxyglucose positron emission tomography/ computed tomography (F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been well-established.

Methods: A retrospective analysis of patients with pancreatic ductal adenocarcinoma was conducted at Seoul National University Bundang Hospital between March 2013 and February 2022. Patients underwent PET/CT at baseline and subsequent radiologic evaluations following chemotherapy.

In Situ Stimuli Transfer in Multi-Environment Shape-Morphing Hydrogels Based on the Copolymer Between Spiropyran and Acrylic Acid.

Smart hydrogels are considered as close mimics to the functions of biological entities. However, the stimuli-responsive performance of hydrogels is often limited by the slow diffusion process during water exchange with the surrounding environment. Here, a homogenous hydrogel composed of a water-soluble spiropyran covalently attached to the polyacrylic acid network is reported.

Safety and Efficacy of Intra-Arterial Chemotherapy Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Head and Neck Squamous Cell Carcinoma.

Objective: To investigate the efficacy and safety of local intra-arterial chemotherapy combined with immune checkpoint inhibitors in the treatment of unresectable head and neck squamous cell carcinoma (HNSCC).

Methods: A retrospective analysis was conducted on the clinical data of eight patients diagnosed with unresectable HNSCC at our hospital from January to December 2023. All patients were diagnosed by pathological diagnosis and treated with intra-arterial chemotherapy combined with immune checkpoint inhibitors.

Engineering Solvent-Coordinated Heterometallic-Organic Frameworks for Wide-Range Tuning of Ultralong Room Temperature Phosphorescence toward Time-Resolved Anticounterfeiting.

Metal-organic frameworks (MOFs) have been proven promising ultralong room temperature phosphorescence (RTP) materials for anticounterfeit due to their unique optical properties. However, it remains a major challenge to achieve the desired phosphorescent properties due to the limited regulatory methods and indistinct mechanism. Herein, the coordination solvent and second metal ion costrategy is firstly proposed to prepare seven robust heterometallic-organic frameworks (HMOFs) with two configurations, ZnMg/Ca-sol [sol = HO, dimethylformamide (DMF), dimethylacetamide (DMA), and formyldiethylamine (DEF)] and ZnSr/Ba-HO, exhibiting different ultralong RTP.

Cardiac Organoid Model Inspired Micro-Robot Smart Patch to Treat Myocardial Infarction.

Post-myocardial infarction (MI), the rapid decrease in pH triggers myocardial cell acidosis, which compromises the therapeutic efficacy of exosomes in MI. The groundbreaking research in the human cardiac organoid MI model suggests that exosomes, when paired with pH adjustment, dramatically reduce cardiomyocyte mortality while maintaining their proliferative potential, underscoring the importance of pH regulation in myocardial preservation. Micro-robot mounted micro-needle (MN) patch is thus proposed, targeting MI-acidic microenvironmet, to deliver exosomes into deep injured tissue.

Unveiling the Origin of Oxygen Framework Stability in Ultra-High Nickel Layered Oxide Cathodes.

Ultra-high nickel layered oxides are recognized as promising cathode candidates for high-energy-density lithium-ion batteries due to their enhanced overall capacity and elevated operating voltage. However, the interlayer sliding of transition metal-oxygen octahedra (TMO6) and the instability of lattice oxygen at high voltages for ultra-high nickel oxide cathodes pose significant challenges to their development. Herein, the origin of oxygen framework stability is investigated by incorporating high-covalent element Mo in both bulk and surface using a one-step integrated method for ultra-high nickel cathode material LiNiCoO.

Bias-Switchable Photomultiplication and Photovoltaic Dual-Mode Near-Infrared Organic Photodetector.

Photomultiplication-type organic photodetectors (PM-OPDs) provide for signal amplification, ideal for detecting faint light, and simplifying detection systems. However, current designs often suffer from slow response speed and elevated dark current. Conversely, photovoltaic-type organic photodetectors (PV-OPDs) provide fast response and high specific detectivity (D) but have limited photoresponse.

Difunctionalization of Alkenes toward 3,3-Disubstituted and Dihydrobenzoindolines by Using an Imidazolylidene Palladacyclic Catalyst.

The synthesis of valuable 2a,3-dihydrobenzo[]indolines was successfully achieved by combining IPr-Pd-Oxa-catalyzed cross-coupling and proton-induced hydroarylation in a one-pot method. In situ-generated alkynyl-functionalized 3,3-disubstituted indolines were proved as the key intermediate, bearing a broad scope of substrates with diverse functional groups and electronic properties.

Formulating Electrophilic Electrolyte for In Situ Stabilization of 4.8 V Li-Rich Batteries with 100% Initial Coulombic Efficiency.

Lithium-rich layered oxide (LLO) cathodes are expected to overcome the energy density limitations, but their applicability is hindered by low initial Coulombic efficiency (ICE) and unstable electrode-electrolyte interphases with sluggish kinetics. Here an elaborate electrophilic electrolyte is proposed that effectively stabilizes the surface lattice oxygen of the LLO cathode, facilitates the formation of dense and fast-ion-transport electrode-electrolyte interphases, and prevents Li-dendrites on the anode. The nucleophilic reaction mechanism driven by the electrolyte enables LLO to exhibit a reversible capacity of 310 mAh g with a record ICE of 100%, as well as impressive 3C fast-charging stability, remarkably superior to that in the basic electrolyte.

Validation of a novel approach to assess metabolic flexibility to a high-fat meal in a whole-body room calorimeter.

Objective: Metabolic inflexibility to Western high-fat diets may contribute to the obesity epidemic. However, validated methods for assessing metabolic flexibility (MetFlex) to high-fat meals are currently lacking. The purpose of this study was to evaluate the reliability of a novel approach for determining MetFlex to a high-fat meal and to compare it with the gold standard for measuring MetFlex to high-carbohydrate loads.

Strain Engineering the Optoelectronic and HER Behavior of MoS/ZnO Heterojunction: A DFT Investigation.

The rational design of heterojunctions by coupling two or more two-dimensional (2D) materials is regarded as a feasible strategy to efficiently enhance photocatalytic-hydrogen performance by capturing solar energy to address the increasing global energy crisis. In this work, a functional MoS/ZnO heterojunction is proposed based on first-principles simulation. Our results reveal that the photogenerated electrons and holes in the MoS/ZnO heterojunction follow a specific Z-scheme pathway, highly facilitating redox reactions and optimizing optical properties in the visible-light region.

WO@Ferrocene-Folic Acid Composites Induce Cancer Cell Death and Activate Immunity via PTT/CDT.

At present, tumor immune escape is a major problem in the treatment of tumors. The complex network of tumor microenvironments significantly impairs the efficacy of immunotherapy. This paper reports the preparation and immunoantitumor activity of a novel multifunctional defect tungsten trioxide@ferrocene-folic acid composite (WO@Fe-FA) with a high Fenton reaction rate.

Rhodium(I)-Catalyzed Asymmetric Cascade Reactions.

Rhodium(I)-catalyzed asymmetric cascade reactions have emerged as powerful tools in contemporary organic synthesis, enabling efficient construction of complex molecular architectures. These transformations proceed through organorhodium intermediates, which undergo additions to reactive π-bonds, subsequently triggering cascade reactions with neighboring functional groups to effectively forge multiple carbon-carbon bonds and stereogenic centers in a single step under mild conditions. This article reviews the pioneering developments and recent breakthroughs from 2002 to 2024, highlighting the attractive advantages of rhodium(I)-catalyzed asymmetric cascade reactions and their profound impacts on synthetic organic chemistry.

FOXA2 Loss in TGF-β1-Induced EMT Suppresses Bisecting-GlcNAc N-Glycan Synthesis in Lung Adenocarcinoma.

Glycosylation, a major posttranslational modification (PTM), is often dysregulated in cancer due to altered glycosyltransferase activity. Studies have shown specific changes in glycan structures associated with epithelial-mesenchymal transition (EMT) in cancer cells. However, the specific mechanism by which glycosyltransferases contribute to EMT remains unclear.

Improving the Long-Term Cycling Stability of Sodium Metal Anodes with LiBF Additives.

The lower redox potential and higher theoretical specific capacity of the sodium metal anode make sodium metal batteries highly promising. However, the uneven plating/stripping behavior of sodium resulted in the growth of sodium dendrites and the decrease in Coulombic efficiency (CE). In this study, LiBF was used as an additive in an ether-based electrolyte.

Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect".

Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking.

Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase reporter assays and CRISPR/Cas9 conditional knockout mice were used to elucidate the distribution characteristics of NFATc1 m6A.