High Entropy Boosts the Low Temperature Na+-storage Performance of Na4Fe3(PO4)2P2O7.

Na4Fe3(PO4)2P2O7 (NFPP) has been considered as a promising cathode material for sodium ion batteries (SIBs). However, the inferior electronic conductivity and inadequate Na+ ions diffusion kinetics of NFPP at low temperatures hinder its practical applications. In this study, high entropy Na4Fe2.

Graphene Nanoribbon Core Thermotropic Liquid Crystal with A Well-Defined Molecular Structure.

Graphene nanoribbons (GNRs) with hierarchical and well-ordered structures are believed to deliver superior performance in semiconductor device applications. Despite this potential, traditional alignment techniques for GNRs often fall short in producing defect-free and precisely defined molecular architectures. Here, we introduce a strategy for the fabrication of highly-ordered GNRs by empowering them with thermotropic liquid crystallinity, utilizing a bottom-up solution synthesis approach.

Developing the Tandem Structure to Regulate Interfacial Chemistry and Promote Ion Transport Kinetics towards High Voltage Lithium Metal Batteries.

The chemical properties of the Solid Electrolyte Interphase (SEI) layer and Cathode Electrolyte Interphase (CEI) are crucial for achieving high-energy-density lithium metal batteries, especially under extreme operating conditions. Herein, we propose a delicately designed tandem separator (CYANO-COF|PP|SnF2) to regulate the chemical stability of dual interfaces. The cyano group in CYANO-COF induces a stable CN-enriched CEI on the surface of high-nickel LiNi0.

In Situ Recovery of Serotonin Synthesis by a Tryptophan Hydroxylase-Like Nanozyme for the Treatment of Depression.

Depression is one of the most common mental disorders. The inactivation of tryptophan hydroxylase and the resulting serotonin decrease are the key factors in depression pathology. Herein, we report for the first time that FeO nanoparticles exhibit tryptophan hydroxylase-like activity and successfully verify their ability to restore serotonin synthesis in the brain for the treatment of depression.

Electron Transfer Energetics in Photoelectrochemical CO Reduction at Viologen Redox Polymer-Modified p-Si Electrodes.

While redox polymer-mediated catalysis at silicon photoelectrodes has been studied since the 1980s, there have been few detailed studies of these materials in photoelectrochemical CO reduction. Here, we develop silicon photoelectrodes functionalized with a viologen-based polymer that mediates the formation of catalytic gold nanoparticles. The presence of gold was confirmed by X-ray photoelectron spectroscopy (XPS), and the nanoparticles were imaged with high-angle annular dark field scanning transmission electron microscopy (HAADF-STEM).

Intraluminal brachytherapy using I seed strand combined with PTBD and Hepatic arterial infusion chemotherapy for unresectable Bismuth-Corlette III and IV stage hilar cholangiocarcinoma.

Purpose: To evaluate the safety and efficacy of I seed strand combined with percutaneous transhepatic biliary drainage (PTBD) and hepatic arterial infusion chemotherapy (HAIC) for unresectable Bismuth-Corlette III and IV stage hilar cholangiocarcinoma (HCCA).

Methods: From January 2018 to December 2021, a total of 128 Bismuth-Corlette III and IV stage HCCA patients with obstructive jaundice were included in this single-center retrospective study. Forty-eight patients underwent I seed strand combined with PTBD and HAIC (group A).

Equivalent-input-disturbance based rotating control of drill-string in compound directional drilling process subject to coal seam variation.

Coal seam variations in coal mine drilling can cause fluctuations in feed speed and rotational speed of the rotary head (ROR), reducing the performance of compound directional drilling control systems. This paper addresses these issues by considering the change in intrinsic specific energy caused by coal seam variations as a disturbance. An equivalent-input-disturbance (EID) based control system is designed to mitigate these effects.

Central Thalamic Deep Brain Stimulation Modulates Autonomic Nervous System Responsiveness in Disorders of Consciousness.

Background: The heart rate variability (HRV) of patients with disorders of consciousness (DOC) differs from healthy individuals. However, there is rarely research on HRV among DOC patients following treatment with deep brain stimulation (DBS). This study aims to investigate the modulatory effects of DBS-on the central-autonomic nervous system of DOC based on the study of HRV variations.

A Hierarchical Multimetal Oxides@Graphene Fabric Electrode with High Energy Density and Robust Cycling Performance for Flexible Supercapacitors.

An advanced structure capable of hosting large electrochemical activity with desired balance in ion diffusion kinetics, faradic charge storage, and robust stability is the key to developing high-performance fabric-based electrochemical supercapacitors (FSCs). Herein, we develop a hierarchical multimetal oxides@graphene fabric (Cu-MO@GFF) as a supercapacitor electrode with accelerated ionic diffusion, adsorption energy, faradic redox reaction kinetics, and electrochemical reversibility. As a result, the Cu-MO@GFF presents excellent mass capacitance (534 F g), high rate performance (266 F g at 10 A g), and good cycle performance (96.

[Analysis of novel mutations in the insulin receptor gene of a family with type A insulin resistance syndrome].

This study aimed to identify mutations in the human insulin receptor gene (INSR) and investigate their role in the pathogenesis of severe insulin resistance syndrome. Sanger sequencing of the INSR gene was performed on a patient clinically suspected of having type A insulin resistance syndrome admitted to the Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital. Upon identifying mutations, relevant exons were sequenced in her first-degree relatives.

[An analysis of clinical and genetic feature in pulmonary artery sarcoma].

To retrospectively analyze the clinical, imaging, pathological and genetic features in patients with pulmonary artery sarcoma (PAS) in a single center, and to investigate the disease origin of PAS, as well as its relationship with other pulmonary vascular diseases. We retrospectively identified and analyzed clinical features of 13 cases with PAS those were admitted in the First Affiliated Hospital of Guangzhou Medical University between January 2015 and January 2021. Whole exome sequencing (WES) was performed to further analyze their genetic characteristics in 8 postoperative specimens.

The Canadian Lung Outcomes in Users of Vaping Devices (CLOUD) Study: protocol for a prospective, observational cohort study.

Introduction: The rapid growth in popularity of e-cigarettes over the past decade has prompted concerns about their impact on long-term respiratory health. Small airway injury is suspected to be a direct consequence of e-cigarette use and may be quantifiable by novel structural and functional diagnostic modalities.

Methods And Analysis: In a multicentre observational longitudinal study, participants will be enrolled in either an adolescent (ages ≥12 and <19 years) or an adult arm (≥19 years old) and followed over 3 years across three time points (baseline, 18 months and 36 months).

PD-1 promotes tumor evasion via deregulating CD8 T cell function.

Background: The programmed cell death 1 (PD-1) is an immune checkpoint that mediates immune evasion of tumors. Alternative splicing (AS) such as intron retention (IR) plays a crucial role in the immune-related gene processing and its function. However, it is not clear whether encoding PD-1 exists as an IR splicing isoform and what underlying function of such isoform plays in tumor evasion.

Observational Study of Curative Effects Between Complete Video-Assisted Thoracoscopic Surgery and Conservative Treatment for Multiple Rib Fractures in Non-Frail Chests.

Background: Multiple rib fractures (MRFs) are common injuries and result in serious morbidity and mortality after trauma. Complete video-assisted thoracoscopic surgery (c-VATS) has been increasingly used in the treatment of MRFs. This study was to compare the clinical effects of c-VATS and conservative treatment for MRFs.

Polarization Imaging Method for Detection of Lung Cancer Based on Symmetrical Single LCVR.

Lung cancer ranks among the three most prevalent cancers worldwide. Polarization imaging technology can effectively distinguish between cancerous and normal tissues. The most commonly applied method for cancer detection is the dual-rotating wave plate polarization imaging system (DWRPIS), which is cumbersome and prone to significant error due to 60 mechanical rotations.

Characterization, digestive properties and glucose metabolism regulation of curcumin-loaded Pickering emulsion.

Curcumin, a polyphenolic compound with antioxidant and hypoglycemic properties, has limited applications due to low stability and poor oral bioavailability. This study aimed to overcome these challenges by developing stable oil-in-water Pickering emulsions with curcumin and evaluating their stability and digestive characteristics. Using a T2DM mouse model, we further examined the effects of curcumin-loaded Pickering emulsions on glucose metabolism.

Protein-polysaccharide based nanogel/hydrogel composite with controlled continuous delivery of drug for enhanced wound healing.

In the development of drug delivery vehicles for full-thickness skin wounds, achieving a specific drug concentration at the active site remains a key challenge. In this work, we reported a novel protein-polysaccharide bio-based composite hydrogel (SG@CRG) with controlled continuous drug delivery for enhanced wound healing. This composite hydrogel was prepared by incorporating drug embedded spirulina protein isolate nanogels (SG) into carboxymethyl chitosan based hydrogel (CRG) network, which exhibited rapid gelation and excellent mechanical properties.

Interfacial engineered biomass-derived G/VMT-PCNCs networks as high-performance proton-conducting humidity sensors.

In this study, a novel proton-conducting film was strategically engineered by interfacial manipulation of green and sustainable biomass resources guanine and phosphorylated cellulose nanocrystals (PCNCs) within vermiculite layers. The interfacial engineering approach involved regulation of molecular interactions at the vermiculite-organic interface, whereby PCNCs were incorporated into the interlayers of guanine/vermiculite composites. This interfacial assembly process guided guanine to form tubular structures or ultrathin nanosheets architectures, enabling the fabrication of guanine/vermiculite-PCNCs (G/VMT-PCNCs) composite films with an active-site-rich and tightly interconnected network via a vacuum-assisted process.

Recent advances in cellulose-based antimicrobial films: A review.

Cellulose, known as the most abundant natural polymer, has renewability, good film-forming, biodegradability, safety, non-toxicity, etc. It can serve as an excellent carrier or substrate for antibacterial agents. In recent years, cellulose antibacterial membranes have become a research hotspot of new antibacterial materials.

Alkali-extracted rhamnogalactoarabinan from Chaetomorpha linum: Characterisation and anti-type 2 diabetic effect.

Sulphated galactoarabinans, extracted from members belonging to the Cladophoraceae (Chlorophyceae) family, have been reported to have potential as novel anti-diabetic agents. However, relatively few studies have investigated this research topic. In the present study, a water-soluble polysaccharide designated CBS2 was obtained from Chaetomorpha linum using dilute alkaline solution, preparative anion exchange, and size-exclusion chromatography.

Cellulose nanofiber-reinforced supramolecular polymer gels for temporary plugging of fractured oil and gas reservoirs.

The development of oil and gas from fractured reservoirs is hindered by reservoir complexity, wellbore instability, lost circulation, and formation fluid intrusion during drilling. Various plugging materials and strategies have been employed; however, physical plugging materials often suffer from mismatched particle and fracture sizes, while chemical plugging materials face challenge with low plugging strength as well as tedious operation conditions. In addition, achieving both high plugging effectiveness during use and superior degradability after service remains a challenge.

Atherosclerotic Cardiovascular Disease Risk Prediction Models in China, Japan, and Korea: Implications for East Asians?

The management of atherosclerotic cardiovascular disease (ASCVD) in the United States is currently based upon large epidemiological studies in primarily non-Hispanic White subjects. Although this strategy provides a uniform approach that is simpler to implement, it may result in inappropriately targeting certain Asian populations for treatment based on inaccurate ASCVD risk estimation. In this state-of-the-art review, we detail the similarities and differences in the prevalence of ASCVD and its risk factors among Chinese, Japanese, and Korean people living in the United States and in their native countries.

Atmospheric chemistry of the coastal area is influenced by the convergence between the inland and marine air: Insight into carbonyl compounds.

Marine biological activity has long been recognized to impact the atmospheric chemistry of coastal areas. In this work, we monitored the seasonal variation of carbonyl compounds in the coastal city of Qingdao, located in the north of China's coastline and the south of Jiaodong Peninsula, with the vast hinterland in the west. The mean total concentration of the 15 carbonyls varied significantly between seasons, with the highest observed in autumn (10.