Stem cell therapy: A promising therapeutic approach for skeletal muscle atrophy.

Skeletal muscle atrophy results from disruptions in the growth and metabolism of striated muscle, leading to a reduction or loss of muscle fibers. This condition not only significantly impacts patients' quality of life but also imposes substantial socioeconomic burdens. The complex molecular mechanisms driving skeletal muscle atrophy contribute to the absence of effective treatment options.

3D-printed CoSi/PCL composite scaffold with NIR-II photothermal ability and enhanced adipogenic activity for breast reconstruction after mastectomy.

Breast reconstruction after mastectomy aims to restore breast appearance and function. Current scaffolds often fail to meet the complex clinical demands of post-mastectomy breast reconstruction, which include personalized shaping, prevention of tumor recurrence and metastasis, and promotion of adipose tissue regeneration. This study aims to address these challenges by combining a readily processable biopolymer, polycaprolactone (PCL), with a multifunctional bioactive ceramic, cobalt orthosilicate (CoSiO, CoSi) to form a multi-functional CoSi/PCL composite scaffold through 3D printing technology.

Innovative 3D-printed porous tantalum cage with non-window design to accelerate spinal fusion: A proof-of-concept study.

An interbody fusion cage is crucial in spine fusion procedures, serving to restore physiological vertebral alignment and reestablish spinal stability. However, conventional fusion cages often face challenges related to insufficient osteointegration and the requirement for substantial bone grafting, which may result in incomplete fusion and prolonged recovery periods. In this study, we harnessed the osteointegration advantages of tantalum (Ta), in conjunction with advanced 3D printing technology, to develop a novel non-window-type Ta cage.

Advances in targeted therapy for tumor with nanocarriers: A review.

The application of Nanocarriers (NCs) provides a promising strategy to solve the problems faced by traditional chemotherapy drugs, like the imprecise delivery, poor bioavailability, high dose requirement, and the tendency to develop multidrug resistance. With the protection of NCs, chemotherapy drugs can reach the lesion site and then release accurately and completely. Although some reviews have summarized the biological applications of NCs, little attention has been given to the advantages and disadvantages of analyzing organic, inorganic, and hybrid NCs separately for targeted therapy and identifying means to further improve the targeting ability.

Two new species of the genus Melichar, 1914 from China (Hemiptera, Fulgoromorpha, Delphacidae, Tropidocephalini).

Two new species of the genus Melichar, 1914 from Southwest China, Lv & Chen, from Guangxi Zhuang Autonomous Region, and Lv & Chen, from Guangdong Province, are described and illustrated. These bring the total number of species in the genus to 13, with nine recorded from China. A checklist and map of all known species of are provided, together with an identification key for Chinese species.

Morphological characteristics and phylogenetic analyses revealed five new species (Basidiomycota) from Southwestern China.

In the present study, five new wood-inhabiting fungal species, (Stereaceae, Russulales), (Punctulariaceae, Corticiales), (Auriculariaceae, Auriculariales), (Incertae sedis, Russulales), and (Punctulariaceae, Corticiales), collected from southern China, are proposed based on a combination of morphological features and phylogenetic evidence. is characterized by membranaceous and smooth basidiomata with white to cream surface and ellipsoid and verrucose basidiospores (9-11 × 5-7 µm); is characterized white to buff, membranaceous basidiomata and ellipsoid, thin-walled and smooth basidiospores (7-8 × 4.5-5.

Three new species of (Diatrypaceae, Xylariales) and a first record of in China with updated description.

Diatrypaceae is a diverse family with a worldwide distribution, occurring on a wide range of hosts in terrestrial and marine environments, some of which are important plant pathogens. During a survey of ascomycete diversity in Guizhou Province, China, three new taxa within are proposed based on morphological comparisons and phylogenetic analyses of combined ITS and sequences data. The newly proposed species are , and .

LINC00461 SNPs rs933647 and rs201864123 modify the risk of adenoid hypertrophy susceptibility for children in South China.

Background: Adenoidal hypertrophy (AH) is commonly observed in childhood and closely linked to obstructive sleep apnea (OSA). Despite the high prevalence of AH, its pathophysiological mechanisms remain incompletely understood. We attempt to explore this issue from a genetic perspective.

SE(3)-Equivariant Ternary Complex Prediction Towards Target Protein Degradation.

Targeted protein degradation (TPD) induced by small molecules has emerged as a rapidly evolving modality in drug discovery, targeting proteins traditionally considered "undruggable". Proteolysis-targeting chimeras (PROTACs) and molecular glue degraders (MGDs) are the primary small molecules that induce TPD. Both types of molecules form a ternary complex linking an E3 ligase with a target protein, a crucial step for drug discovery.

Soil properties and rhizosphere interactions affecting nitrous oxide emissions with mitigation by nitrification inhibitors in rice growth stages.

Nitrous oxide (NO) emissions from paddy soils, particularly from the rice rhizosphere, significantly contribute to agricultural greenhouse gas outputs. This study explores NO emission dynamics in rhizosphere (R) and non-rhizosphere (NR) soils from two distinct paddy types (JR and YC) during the primary rice growth stages (tillering, jointing, heading, and grain-filling). Cumulative NO emissions were measured at 688.

Mycorrhizal fungus BJ1, a new species of sp.: its biological characteristics and promoting effect on seed germination of .

Mycorrhizal fungi have been shown to promote seed germination and seedling growth in Orchidaceae plants. In the present study, a mycorrhizal fungus designated as BJ1 was isolated from the roots of (Thunb.) Reiehb.

Comparison of the accuracy of an ultrasonic-based jaw tracking device with conventional electronic tracking device.

Purpose: This study aimed to evaluate the accuracy of the ultrasonic jaw tracking system by comparing with the conventional electronic system in recording condylar movements.

Materials And Methods: Twenty-six subjects with normal occlusion participated in the study. The CADIAX 4 and Jaw Motion Analyzer (JMA) systems were used to record condylar movement trajectories during mandibular border movements (protrusive/retrusive, lateral, and wide mouth opening), with each movement repeated three times.

Mapping the Knowledge Landscape of and Emerging Future Trends in Stem Cell Therapy for Osteoarthritis: A Bibliometric Analysis of the Literature From 1998 to 2024.

Objective: The purpose of this study was to conduct a bibliometric analysis of the literature on stem cell therapy for osteoarthritis (OA) to visualize recent developments, identify hot spots, and determine trends in the field.

Background: OA is a chronic disease that affects the joints and their surrounding tissues, leading to progressive damage to the articular cartilage and ultimately to the subchondral bone and the surrounding synovial structures. OA is a disabling disease with an increasing incidence and prevalence in the general population.

Inhibition of the Hippo pathway by verteporfin reduces the proliferation and stemness of rat hair follicle neural crest stem cells under hypoxia.

Hair follicle neural crest stem cells reside in the bulge region of the outer root sheath of hair follicles, originate from the ectoderm, and have multidirectional differentiation potential, making them ideal candidates for tissue engineering applications. These cells mainly reside in a hypoxic microenvironment that favors the maintenance of stemness. Recently, many studies have elucidated the involvement of the Hippo pathway in the regulation of stem cell fate.

Enhancement of adipose stem cell quality via Cu-MON: Transcriptome and bioinformatics analysis of normal and diabetic stem cells.

Transplanted adipose stem cells (ASC) have a low survival rate in the body, and there are not many ASC that can be effectively used, which weakens their tissue repair function. Based on this status quo, a new type of copper-based metal-organic network (Cu-MON) was used to pretreat cells to regulate cell activity in order to improve the efficacy of cell therapy or reduce the number of cells used, thus reducing the cost of clinical treatment. Gene expression changes before and after Cu-MON treatment of normal donor adipose stem cells (ND-ASC) and type 2 diabetes mellitus adipose stem cells (T2DM-ASC) were evaluated through RNA sequencing, KEGG and GO enrichment analysis.

Systematic benchmarking of tools for structural variation detection using short- and long-read sequencing data in pigs.

Evaluating diverse structural variation (SV) detection-relevant programs leveraging different algorithms has become a pressing need in humans and farm animals. We addressed this by sequencing five genetically diverse pig individuals (breeds) with short- and long-read DNA-sequencing platforms. We created the SV benchmark set for each breed and assessed the performance of 16 SV calling-relevant tools.

The impact of lymph node dissection on stage I ovarian endometrioid carcinoma: A US-China Comparative Analysis.

This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database conducted in USA and NUWA database in China, we found that patients who underwent LND in the SEER cohort exhibited significantly improved long-term survival rates compared to those who did not undergo LND, while the difference was not statistically significant in the NUWA cohort. Cox regression and restricted cubic spline analyses indicated an inverted U-shaped association between the number of LNDs and hazard ratios, identifying 29-34 lymph nodes as the optimal range.

Blockade of TSP-1/CD47 signal axis promotes donor hematopoietic engraftment by improving SEC/MK niche function.

Thrombospondin-1 (TSP-1)/CD47 signaling induces cell death and inhibits angiogenesis. Here, we investigated the possibility of improving donor engraftment by blocking the TSP-1/CD47 pathway in mouse models of total body irradiation (TBI)-conditioned syngeneic hematopoietic stem cell transplantation (HSCT). Our findings revealed that HSCT engraftment was improved in mice deficient in CD47 ( ) or TSP-1 ( ) compared to wild-type (WT) mice.

Unveiling circulating targets in pancreatic cancer: Insights from proteogenomic evidence and clinical cohorts.

Pancreatic cancer (PC), characterized by the absence of effective biomarkers and therapies, remains highly fatal. Data regarding the correlations between PC risk and individual plasma proteome known for minimally invasive biomarkers are scarce. Here, we analyzed 1,345 human plasma proteins using proteome-wide association studies, identifying 78 proteins significantly associated with PC risk.

Research on a Concentration Detection Method for Turbid Media Based on Multipath Combination.

In order to improve the accuracy of concentration detection in turbid media, this study proposes a solution concentration detection method based on a variable-angle wedge-shaped sample cell. Each angle of the wedge-shaped sample cell corresponds to a specific optical path combination. By measuring at multiple wedge angles, we can expand a variety of optical path combinations, providing more information about the turbid media.

Grignard Method for Preparing Thioesters from Esters and Its Application to One-Pot Synthesis of Ketones and Aldehydes.

A new protocol for preparing thioesters from the corresponding methyl esters was developed using PrMgCl and odorless 1-dodecanthiol, CHSH, under mild reaction conditions, during which in situ-generated CHSMgCl selectively reacted with the carbonyl group of esters. A variety of aromatic and aliphatic esters were readily converted in up to 99% yield with excellent functional group tolerance. Furthermore, based on the quantitative formation of the thioesters, we successfully applied our method to a one-pot synthesis of ketones and aldehydes from esters.

Simulation and Analysis of a Novel Hydrogen Liquefaction Process Based on the Liquid Nitrogen and Helium Joule-Brayton Cycle.

To facilitate the design, analysis, and optimization of the hydrogen liquefaction system, this study developed a MATLAB-based independent simulation program encompassing unit equipment models and exergy analysis models. The program incorporated REFPROP software to accurately calculate fluid physical properties and the heat of conversion between ortho- and parahydrogen. The proposed hydrogen liquefaction process utilized LN precooling, the helium Joule-Brayton cryogenic cycle, and a throttle valve to efficiently produce liquid hydrogen.

Effectiveness Evaluation on Network Fracturing in Ultra-Deep and Extremely Thick Reservoirs in Kuqa Piedmont-A Case Study of Well KS2-A.

In the Keshen Gas Field in Kuqa Piedmont, the Cretaceous Bashijiqike formation is the main producing layer. The deepest exploratory wells exceed 8000 m, with reservoir pressures reaching 150 MPa, temperatures peaking at 190 °C, and formation thicknesses ranging from 100 to 300 m. The extreme operating conditions and well-controlled risks limit the testing methods after stimulation.

Study on the Effect of Hydraulic Flushing on the Stress and Permeability Variations of Loaded Coal.

Coal seams in China are characterized by low permeability, high gas pressure, and soft coal, which lead to challenging gas extraction and severe gas disasters. Hydraulic flushing is widely used in the field to enhance the permeability of coal seams. Considering this fact, studying its effect on the stress and permeability variations of loaded coal is essential for upgrading the hydraulic flushing permeability enhancement technology.

Designed Fabrication of SnO/InO/C Electrochemical Sensors for Coolant Leakage Detection in Energy Storage Systems.

The liquid cooling system for lithium iron phosphate battery modules usually faces the threat of coolant leakage, which would dramatically affect the heat transfer performance, safety, and efficiency of the energy storage system. Herein, electrochemical sensing technology has been first employed to detect coolant leakage. Specifically, ethanol is selected as the additive reagent and used as the main tested substance, and the sensors indirectly identify the coolant leakage by detecting the leaked ethanol.