Exploring the Structural Origins of Optically Efficient One-Dimensional Lead Halide Perovskite Nanostructures.

Metal halide perovskites have excellent optoelectronic properties. This study aims to determine how the optoelectronic properties of a model perovskite, cesium lead bromide (CsPbBr), change with length and thickness in one dimension (1D). By examining the photophysics of CsPbBr quantum dots (QDs), nanowires (NWs), and nanorods (NRs), we observe the influence of confinement, exciton diffusion, and trapping on their optical properties.

Engineering Perovskite Hydroxide as a Cold-Adapted Oxidase Mimic for Construction of the Robust Low-Temperature Adaptive Biosensors.

Traditional biological detection methods rely on signal amplification strategies such as enzymatic catalysis or nucleic acid amplification. However, their efficiency decreases in low-temperature environments, compromising their detection sensitivity. To break the loss of enzyme catalytic activity at low temperatures, research on cold-adaptive nanozymes has attracted much attention.

Efficacy of Combined CD38 and PD1 Inhibition with Isatuximab and Cemiplimab for Relapsed/Refractory NK/T-Cell Lymphoma.

This study aimed to assess the efficacy and safety of combining cemiplimab, an anti-PD1 antibody, with isatuximab, an anti-CD38 antibody, in relapsed or refractory extranodal NK/T-cell lymphoma (R/R ENKTL). The hypothesis was that CD38 blockade could enhance the antitumor activity of PD1 inhibitors. Eligible patients received cemiplimab (250 mg on days 1 and 15) and isatuximab (10 mg/kg on days 2 and 16) intravenously every four weeks for six cycles.

Effect of Diethanolamine after Carbon Dioxide Absorption and Desorption on Mechanical Strength of Cement Mortar and Mechanism.

Diethanolamine (DEA) can be used not only as a cement admixture but also to capture carbon dioxide (CO). However, the waste liquid treatment still faces the problems of high energy consumption and increasing environmental burden. The effects of DEA waste liquid (WL-DEA) with multiple cycles of CO absorption and desorption on the setting time, hydration temperature, mechanical strength, and microstructure of cement-based materials were explored.

Inflammatory Microenvironment-Modulated Conductive Hydrogel Promotes Vascularized Bone Regeneration in Infected Bone Defects.

Infected bone defects show a significant reduction in neovascularization during the healing process, primarily due to persistent bacterial infection and immune microenvironmental disorders. Existing treatments are difficult to simultaneously meet the requirements of antibacterial and anti-inflammatory treatments for infected bone defects, which is a key clinical therapeutic challenge that needs to be addressed. In this study, a conductive hydrogel based on copper nanoparticles was developed for controlling bacterial infection and remodeling the immune microenvironment.

High-performance magnesium organic batteries using renewable biomolecule-based cathode.

Rechargeable magnesium batteries (RMBs) exhibit significant potential in large-scale energy storage due to their features of high volumetric capacity, resistance to dendrite formation, and abundant magnesium resources. However, the high polarity of divalent Mg2+ ions results in sluggish diffusion kinetics in conventional inorganic cathode materials, adversely affecting reversible capacity and rate performance. Organic materials such as pyrene-4,5,9,10-tetrone (PTO) and 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA), achieve rapid and reversible intercalation of magnesium ions through carbonyl enolization, but these materials are challenged by high cost, complex preparation, and poor environmental friendliness.

CAD manipulates tumor intrinsic DHO/UBE4B/NF-κB pathway and fuels macrophage cross-talk, promoting hepatocellular carcinoma metastasis.

Background And Aims: Portal vein tumor thrombosis (PVTT), an indicator of clinical metastasis, significantly shortens hepatocellular carcinoma (HCC) patients' lifespan, and no effective treatment has been established. We aimed to illustrate mechanisms underlying PVTT formation and tumor metastasis, and identified potential targets for clinical intervention.

Approach And Results: Multi-omics data of 159 HCC patients (including 37 cases with PVTT) was analyzed to identify contributors to PVTT formation and tumor metastasis.

AJGM: Joint Learning of Heterogeneous Gene Networks with Adaptive Graphical Model.

Motivation: Inferring gene networks provides insights into biological pathways and functional relationships among genes. When gene expression samples exhibit heterogeneity, they may originate from unknown subtypes, prompting the utilization of mixture Gaussian graphical model for simultaneous subclassification and gene network inference. However, this method overlooks the heterogeneity of network relationships across subtypes and does not sufficiently emphasize shared relationships.

Co-Exposure to Polystyrene Microplastics and Bisphenol A Contributes to the Formation of Liver Fibrosis in Mice through Inhibition of the BMAL1/E-Cad Signaling Pathway.

The food safety risks posed by exposure to polystyrene microplastics (PS-MPs) and bisphenol A (BPA) have become an issue worldwide. However, the toxic effects of PS-MPs and BPA coexposure on the mammalian liver remain elusive. In this study, we found that PS-MPs and BPA coexposure have synergistic toxic effects on AML12 cells and the mouse liver.

Ultralong Room Temperature Phosphorescence through Both Space Confinement and Long-Range Charge Migration.

Doping guest materials into host materials with a confined space to suppress nonradiative decay is an effective strategy for achieving room-temperature phosphorescence (RTP). However, constructing host-guest doped materials with ultralong RTP (URTP) is still challenging. Herein, by embedding three coumarin derivatives into boric acid via one-step heat treatment, the URTP material with an afterglow lasting up to 60 s, a phosphorescence lifetime of 1.

Heterogeneous cellular responses to hyperthermia support combined intraperitoneal hyperthermic immunotherapy for ovarian cancer mouse models.

The benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in ovarian cancer remains controversial, hindering the development of rational combination therapies based on hyperthermia (HT). This study reports the preliminary results of the neoadjuvant HIPEC (NHIPEC) trial (ChiCTR2000038173), demonstrating enhanced tumor response in high-grade serous ovarian cancer with NHIPEC. Through single-cell RNA sequencing analysis, we identified both homogeneous and heterogeneous cellular responses to HT within the tumor and microenvironment.

A flexible pressure sensor array for self-powered identity authentication during typing.

The keyboard, a staple tool for information entry and human-machine interaction, faces demands for enhanced information security due to evolving internet technologies. This study introduces a self-powered flexible intelligent keyboard (SFIK) that harnesses the giant magnetoelastic effect to convert the mechanical pressure from key presses into electrical signals. The sensor boasts a wide sensing range (35 to 600 kPa) and a rapid response time (∼300 ms), allowing it to record and recognize individual keystroke dynamics.

FAP-catalyzed in situ self-assembly of magnetic resonance imaging probe for early and precise staging of liver fibrosis.

Liver fibrosis is an inevitable stage in the progression of most chronic liver diseases. Early diagnosis and treatment of liver fibrosis are crucial for effectively managing chronic liver conditions. However, there lacks a noninvasive and sensitive imaging method capable of early assessing fibrosis activity.

Refugium amidst ruins: Unearthing the lost flora that escaped the end-Permian mass extinction.

Searching for land refugia becomes imperative for human survival during the hypothetical sixth mass extinction. Studying past comparable crises can offer insights, but there is no fossil evidence of diverse megafloral ecosystems surviving the largest Phanerozoic biodiversity crisis. Here, we investigated palynomorphs, plant, and tetrapod fossils from the Permian-Triassic South Taodonggou Section in Xinjiang, China.

Immune memory in hepatitis E virus: a comparative study of natural infection and vaccination in a nursing home population.

Immune memory is crucial for preventing hepatitis E virus (HEV) infection. Our study aims to investigate immunological memory characteristics and differences between vaccination and natural HEV infection, taking into account that both can induce immune memory. We recruited 60 HEV-infected patients, 58 contingency HEV-vaccinated individuals and 4 controls from an outbreak of hepatitis E in a nursing home between June and August 2023.

Fish requires FasL to facilitate CD8+ T-cell function and antimicrobial immunity.

Although bony fish have CD8+ T cells, the mechanisms by which these early-evolved cytotoxic cells combat intracellular pathogens remain unclear. In the present study, using Nile tilapia as a model, we investigated the detailed function, mechanism, and evolutionary pattern concerning CD8+ T cells. By depleting CD8+ T cells, they are found essential in combating Edwardsiella piscicida infection.

Precise Identification of Inhibitors for Coagulation Reactions from Complex Extracts through Monitoring of Biological Aggregates Combined with a Targeted Fishing Technique.

Biological aggregates play a crucial role in the pathogenesis of thrombotic diseases, especially thrombin-induced biological aggregates. Therefore, the efficient discovery of thrombin inhibitors is of great significance for the prevention and treatment of thrombotic diseases. In this study, the aggregation precursor protein fluorescent probe was successfully prepared for monitoring the production of biological aggregates induced by thrombin.

Analysis of the release pattern of floral aroma components of Rhus chinensis based on HS-SPME-GC-MS technique.

Rhus chinensis, a native plant species of China, possesses significant economic value in the ornamental sector. This study investigates the floral fragrance components and release patterns of R. chinensis, thus providing a theoretical foundation for the utilization of its floral fragrance.

The efficacy of the corpus-based error correction method on revision in writing classrooms.

Despite the growing interests in investigating the application of data-driven learning (DDL), much existing research remains outcome-oriented. Limited attention has been paid to learners' interactions with corpora, especially the experiences of consulting corpora and decision-making processes during revision in second language (L2) writing. In this regard, this study investigates how corpora assist language learning during the revision process in a classroom-based foreign language learning context.

Effects of mental fatigue on isometric mid-thigh pull performance and muscle activities.

This study investigated the effects of mental fatigue on rate of force development (RFD) and peak force during an isometric mid-thigh pull (IMTP), as well as its impact on muscle activation measured by electromyography (EMG) median frequency. Sixteen healthy, resistance-trained males completed two sessions: a control condition and a mentally fatigued state induced by a 30-minute modified Stroop task. IMTP performance and muscle activation were assessed before and after the mental fatigue task.

Electricity-Efficient On-Demand Photothermal Activation for Tunable Thermochromic Windows.

Thermochromic (TC) windows with passively controlled sunlight regulation have demonstrated significant building energy conservations. Realizing the active control of the TC window can expand its popularity while remaining an intractable challenge. Herein, a low-power-dissipative strategy that endows TC windows with an actively tunable transmittance is presented through the electro-induced tunable photothermal conversions (ETPCs).

Quantifying Environmental Waste From Diabetes Devices in the U.S.

Objective: Diabetes devices, including continuous glucose monitors (CGMs) and insulin pumps, may significantly affect environmental sustainability and long-term resilience.

Research Design And Methods: This observational study enrolled 49 adults with diabetes using CGMs, insulin pumps, or multiple daily injections (MDIs; three or more per day). Participants completed daily surveys detailing the types and amounts of diabetes-related waste discarded.

Hollow Au nanoparticles for single-molecule Raman spectroscopy a synergistic electromagnetic and chemical enhancement strategy.

Raman spectroscopy has demonstrated significant potential in molecular detection, analysis, and identification, particularly when it adopts single-molecule surface-enhanced Raman scattering (SM-SERS) substrates. A recent SM-SERS scheme incorporates two-fold Raman enhancement mechanisms: the electromagnetic enhancement enabled by a plasmonic nanogap hotspot formed from gold sphere nanoparticles sitting on a gold mirror and the chemical enhancement enabled by a two-dimensional material, WS, inserted into the nanogap. In this work we integrate multiple advanced concepts and techniques to achieve remarkable performance improvements of SM-SERS.

Insights into phosphorylation-induced influences on conformations and inhibitor binding of CDK6 through GaMD trajectory-based deep learning.

The phosphorylation of residue T177 produces a significant effect on the conformational dynamics of CDK6. Gaussian accelerated molecular dynamics (GaMD) simulations followed by deep learning (DL) are applied to explore the molecular mechanism of the phosphorylation-mediated effect on the conformational dynamics of CDK6 bound by three inhibitors 6ZV, 6ZZ and 0RS, in which 6ZV and 6ZZ have been used to test clinical performance. The DL finds that the β-sheets, αC helix as well as the T-loop are involved in obvious differences of conformation contacts and suggests that the T-loop plays a key role in the function of CDK6.