Resurfacing receptor binding domain of Colicin N to enhance its cytotoxic effect on human lung cancer cells.

Colicin N (ColN) is a bacteriocin secreted by () to kill other Gram-negative bacteria by forcefully generating ion channels in the inner membrane. In addition to its bactericidal activity, ColN have been reported to selectively induce apoptosis in human lung cancer cells via the suppression of integrin modulated survival pathway. However, ColN showed mild toxicity against human lung cancer cells which could be improved for further applications.