[The classification of postmastectomy edema of the upper extremity by a volumetric method].

An installation was developed to precisely evaluate size of the extremity by measuring volume of displaced liquid. A classification of postmastectomy edema of the arm was suggested.

[Pathomorphosis of cancer of the breast during thermoradiotherapy].

Local UHF-hyperthermia in combined therapy of breast cancer patients as compared to preoperative radiotherapy used alone, resulted in more noticeable therapeutic changes in a tumor. This fact was established during a study of tumor pathomorphosis in 206 patients with stage II breast cancer. A degree of therapeutic tumor pathomorphosis showed good correlation with the frequency and duration of a recurrence-free period of disease.

[Long-term results of the radical treatment of patients with breast cancer using sterno-axillary mastectomy].

2,023 patients with breast tumors of medial and central localization (aged up to 60 years) received radical treatment at the Institute and oncological dispensaries of the Republic in 1967-1981 (extensive mastectomy after Urban-Kholdin-680; mastectomy after Halsted-1,343). Extensive mastectomy appeared to considerably improve 5-year survival results in patients with T1-3NO, 1MO tumors.

[Degree of radiation pathomorphosis of a tumor and the results of combination treatment of breast cancer].

The long-term results of the combined therapy of 284 patients with infiltrative forms of breast cancer were correlated with the manifestations of radiation pathomorphosis in a tumor after preoperative radiation therapy at a single dose of 4 Gy, summary dose of 20 Gy. Surgical intervention was performed in 59% of the patients in the first 3 days after irradiation, in 30% of the patients in 4-9 days, in 11% in 10-20 days. The degree of radiation pathomorphosis was evaluated by the signs of disturbance of the general structure of the tumorous tissue and the structure of some cancer cells.

[Comparison of the effectiveness of preoperative radiation and thermoradiation therapy in treating breast cancer].

Based on an analysis of the 3- and 5-year results of the combined treatment of 865 patients with breast cancer using 4 variants of radiation exposure in the preoperative period the following aspects are discussed: 1) the conventional variant of gamma-beam therapy at summary doses of 40-45 Gy is not an optimum variant of preoperative irradiation; 2) better results are achieved with the preoperative irradiation of the affected breast and zones of regional metastasis at a single dose of 4 Gy and a summary dose of 20 Gy; 3) a marked tendency towards achieving still better results of treatment and a statistically significant decrease in the frequency of distant metastases detected in the first 2 years after treatment are noted with the use of two other variants of preoperative exposure: an increase in the doses in tumor growth zones up to the level which is equivalent to a carcinocidal dose and a short course of preoperative irradiation (20 Gy) under the conditions of local UHF-hyperthermia.

[Comparative analysis of the effectiveness of standard and large dose fractionation in preoperative breast cancer irradiation].

The report deals with a retrospective comparison of the effectiveness of standard and large-fractionated preoperative radiation therapy of breast cancer patients (each group included 85 females). As a result of distant irradiation with daily single doses of 4 Gy (total dose--20 Gy), preoperative admission period was reduced 5--7 times, as compared with standard single doses of 2 Gy and total dosage of 40--45 Gy. Large--fractionated radiation therapy results in a relatively low incidence of general and local reactions, does not interfere with surgery and is followed by postoperative complications in fewer cases.