Clinical criteria for the switch of treatment strategies in Parkinson's disease.

Along the years the treatment of Parkinson's disease with L-dopa has revealed unfavorable effects in general after 5-10 years. This has led to the present criteria for treatment of de novo patients that mainly relay on the age, the general strategy being to delay the use of L-dopa as long as possible. However, this practical approach lacks a scientific basis.

[Cholecystopathies with mucosal metaplasia of the intestinal type].

In this work we analyse 23 clinical observations on operated cholecystopathies, with intestinal mucosa metaplasia and we present a study hypothesis that remains to be further verified. The clinical cases have been selected out of out of 1263 cholecystopathies carried out within our department between 1987-1993. Most of the patients were females aged of 30-50 years old and were not known to have gallbladder malformations or biliary lithiasis.

Bilateral trunkal vagotomy (BTV) regarded as a pathogenic process. An experimental study.

Experimentally, bilateral trunkal vagotomy (BTV) generated some early acute modifications represented during the first 14 days by blood stasis, partial thrombosis, inflammatory infiltrates and necrobiosis of the gastric mucosa. The vascular lesions are the first to occur, the tissular ones being secondary. Later on, two and three months after surgery, chronic inflammation and metaplasia of the intestinal type have been detected as well.