[Surgical treatment of colon cancer in advanced age patients with severe comorbidities].

Objective: To analyze surgical (including minimally invasive) treatment of advanced age patients with colon cancer and severe comorbidities.

Material And Methods: Advanced age patients with colon cancer (≥60 years) were compared with younger ones. Concomitant diseases were detected in 94,4% of older patients and in 45,9% of patients in the control group (χ=51,747; <0,001).

[Early and long-term outcomes of minimally invasive interventions in urgent colon surgery].

Objective: To analyze the results of minimally invasive surgical treatment of patients with urgent colon diseases.

Material And Methods: There were 89 patients with urgent colon diseases. All patients were divided into 2 groups: the main group - 31 patients who underwent laparoscopic surgeries, the control group - 58 patients operated via open access.

[Surgical treatment of acute calculous cholecystitis followed by one-day discharge of patients].

Aim: To develop rational tactics of surgical treatment of patients with acute calculous cholecystitis with their subsequent discharge within 1 day since admission.

Material And Methods: There were 283 patients with acute cholecystitis and 58 patients with chronic cholecystitis. All patients underwent laparoscopic cholecystectomy.

[Minimally invasive surgery for colorectal cancer in advanced age patients].

Aim: To evaluate the role of laparoscopic surgery for colorectal cancer in advanced age patients.

Material And Methods: 290 patients with colorectal cancer were enrolled including 121 patients with rectal cancer and 169 patients with colon cancer. Main group consisted of 171 patients over 60 years old, control group - 119 patients younger 60 years old.

[Efficacy of video-assisted procedures in advanced age patients with colorectal cancer].

Aim: To assess advisability of video-assisted surgery in advanced age patients with colorectal cancer.

Material And Methods: The study involved 44 patients with large intestine tumors. There were 30 patients with colon cancer aged 78.

[Emergency endoscopic surgery of colon cancer].

Aim: To assess the role of endoscopic technologies in treatment of complicated forms of colorectal cancer.

Material And Methods: Our trial included patients after endoscopic intervention (n=18) and open surgery (n=11).

Results: Mean time of surgery in this group was 158.

[Endoscopic interventions in patients with colorectal cancer: the effect of comorbidities].

Aim: To evaluate endoscopic technologies in treatment of patients with colorectal cancer and severe comorbidities.

Material And Methods: Two groups of patients after endoscopic (group 1, n = 58) and open (group 2, n = 40) surgery were assessed.

Results: Comorbidities were observed in 90.

[Laparoscopic surgery for colon cancer].

Aim: To assess laparoscopic surgery in treatment of colon cancer patients.

Material And Methods: The results of laparoscopic treatment of patients with colorectal cancer are presented in the article. It was estimated the influence of various clinical parameters including age, gender, comorbidities, tumor localization and stage and complications on laparoscopic management of these patients.

[Results of surgical treatment of cholelithiasis by laparotomic and minimally invasive accesses].

The article presents the results of surgical treatment of 1038 patients with cholelithiasis, acute and chronic calculous cholecystitis and complicated forms of the disease. Operations were performed with traditional laparotomic and minimally invasive approaches. Indications for choosing access, as well as the advantages and disadvantages of various options of surgery in patients with cholelithiasis are discussed.

[Laparoscopic cholecystectomy in case of acute cholecystitis].

The article describes the results of laparoscopic cholecystectomy in patients with acute cholecystitis. 97 patients including 13 men and 84 women aged from 20 to 74 years were included in the study. There was not the conversion to laparotomy and intraoperative complications in all cases.

[Minilaparotomy cholecystectomy in patients with acute calculous cholecystitis].

It was done the analysis of surgical treatment results of 383 patients with the exacerbation of chronic calculous cholecystitis and acute obstructive calculous cholecystitis. All patients were operated from traditional and minilaparotomy approaches. Positive results were obtained in 93.

Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus.

Numerous genetic studies have shown that the CREB-binding protein (CBP) is an essential component of long-term memory formation, through its histone acetyltransferase (HAT) function. E1A-binding protein p300 and p300/CBP-associated factor (PCAF) have also recently been involved in memory formation. By contrast, only a few studies have reported on acetylation modifications during memory formation, and it remains unclear as to how the system is regulated during this dynamic phase.

HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.

A critical step of neuronal terminal differentiation is the permanent withdrawal from the cell cycle that requires the silencing of genes that drive mitosis. Here, we describe that the alpha isoform of the heterochromatin protein 1 (HP1) protein family exerts such silencing on several E2F-targeted genes. Among the different isoforms, HP1alpha levels progressively increase throughout differentiation and take over HP1gamma binding on E2F sites in mature neurons.

Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model.

Amyotrophic lateral sclerosis (ALS) is characterized by motoneuron (MN) degeneration, generalized weakness, and muscle atrophy. The premature death of MNs is thought to be a determinant in the onset of this disease. In a transgenic mouse model of ALS expressing the G86R mutant superoxide dismutase 1 (mSOD1), we demonstrated previously that CREB (cAMP response element-binding protein)-binding protein (CBP) and histone acetylation levels were specifically decreased in nuclei of degenerating MNs.

Preconcentration and fluorimetric determination of polycyclic aromatic hydrocarbons based on the acid-induced cloud-point extraction with sodium dodecylsulfate.

The acid-induced cloud-point extraction (CPE) technique based on sodium dodecylsulfate (SDS) micelles has been used for preconcentration of ten representatives of polycyclic aromatic hydrocarbons (PAHs) for the following fluorescence determination. The effect of the acidity of solution, SDS and electrolyte concentrations, centrifugation time and rate on the two-phase separation process and extraction percentages of PAHs have systematically been examined. Extraction percentages have been obtained for all PAHs after CPE ranged from 67 to 93%.

HDAC-3 participates in the repression of e2f-dependent gene transcription in primary differentiated neurons.

Activation of e2f-1 gene expression is an event that has been now established in many models of neuronal apoptosis. Accumulated E2F-1 protein has also been observed in post mortem brains obtained from patients suffering from different neurodegenerative diseases. We have previously shown in primary neuronal cultures that e2f-1 gene transcription was actively repressed in neuroprotective conditions through HDAC-dependent regulation on the E2F-responsive elements (E2F-REs) located in the e2f-1 gene promoter.

[Effect of physical load on serum protein glycation in rats with induced diabetes].

Decreased levels of early and advanced glycation products were found in exercise-training diabetic rats as compared with sedentary diabetic rats. Adaptation to systemic physical exercise in diabetic animals affects not only enzyme-regulated metabolism but also non-enzymatic processes involving protein glycation.