Partially Reversible Episode of Blindness after Intravascular Hyaluronic Acid Filler Injection.

Blindness from hyaluronic acid filler injections is an uncommon but devastating complication. We present a case of blindness related to a "skin booster." It is often assumed that skin boosters have no risk of visual problems, and this case underlines the need to understand products' rheology and chemistry.

Incremental Efficacy for Repeat Ablation Procedures for Catheter Ablation of Atrial Fibrillation: 5-Year Follow-Up.

Background: Catheter ablation atrial fibrillation (AF) is effective, but 20% to 40% of patients will require a repeat ablation. The role of more than 1 repeat ablation is not well known.

Objectives: The purpose of this study was to evaluate the effectiveness and incremental benefits of multiple repeat catheter ablations to treat AF in patients.

miR-21 attenuated inflammation targeting MyD88 in human chondrocytes stimulated with Hyaluronan oligosaccharides.

Inflammation is the body's response to injuries, which depends on numerous regulatory factors. Among them, miRNAs have gained much attention for their role in regulating inflammatory gene expression at multiple levels. In particular, miR-21 is up-regulated during the inflammatory response and reported to be involved in the resolution of inflammation by down-regulating pro-inflammatory mediators, including MyD88.

A GIS-based land suitability model for agricultural tractors in CALABARZON Region, Philippines.

Agricultural machinery distribution programs are key components of the Philippine government to strengthen its economic productivity. However, concerns were reported that some of the distributed machines were under-utilized or unutilized in their respective farms. This study is focused on the development of a GIS-based model of determining suitable lowland rice areas for two-wheel and four-wheel tractors.

Fine Alignment of Thermographic Images for Robotic Inspection of Parts with Complex Geometries.

Increasing the efficiency of the quality control phase in industrial production lines through automation is a rapidly growing trend. In non-destructive testing, active thermography techniques are known for their suitability to allow rapid non-contact and full-field inspections. The robotic manipulation of the thermographic instrumentation enables the possibility of performing inspections of large components with complex geometries by collecting multiple thermographic images from optimal positions.

The Role of Patient-Specific Morphological Features of the Left Atrial Appendage on the Thromboembolic Risk Under Atrial Fibrillation.

Background: A large majority of thrombi causing ischemic complications under atrial fibrillation (AF) originate in the left atrial appendage (LAA), an anatomical structure departing from the left atrium, characterized by a large morphological variability between individuals. This work analyses the hemodynamics simulated for different patient-specific models of LAA by means of computational fluid-structure interaction studies, modeling the effect of the changes in contractility and shape resulting from AF.

Methods: Three operating conditions were analyzed: sinus rhythm, acute atrial fibrillation, and chronic atrial fibrillation.

Effects of semaglutide on cardiovascular risk factors and eating behaviors in type 2 diabetes.

Aims: Aim of the present study was to evaluate the impact of once-weekly semaglutide on different end-points indicative of metabolic control, cardiovascular risk, dietary behavior, and treatment satisfaction in T2DM.

Methods: This was a retrospective observational study conducted in a diabetes clinic. Changes in HbA1c, fasting blood glucose (FBG), weight, blood pressure, lipid profile, and number of antihypertensive drugs at 32 weeks (T1) after the first prescription of semaglutide (T0) were analyzed.

Left bundle branch area pacing in patients with atrioventricular conduction disease: A prospective multicenter study.

Background: The reported success rate of His-bundle pacing (HBP) in patients with infranodal atrioventricular (AV) conduction disease is only 52%-76%. The success rate of left bundle branch area pacing (LBBAP) in this cohort is not well studied.

Objective: The purpose of this study was to evaluate the feasibility, safety, and electrophysiological characteristics of LBBAP in patients with AV conduction disease.

Continuous Microfiber Wire Mandrel-Less Biofabrication for Soft Tissue Engineering Applications.

Suture materials are the most common bioimplants in surgical and clinical practice, playing a crucial role in wound healing and tendon and ligament repair. Despite the assortment available on the market, sutures are still affected by significant disadvantages, including failure in mimicking the mechanical properties of the tissue, excessive fibrosis, and inflammation. This study introduces a mandrel-less electrodeposition apparatus to fabricate continuous microfiber wires of indefinite length.

Testing the Dispersion of Nanoparticles in a Nanocomposite with an Ultra-Low Fill Content Using a Novel Non-Destructive Evaluation Technique.

A non-destructive evaluation (NDE) technique capable of testing the dispersion of nanoparticles in a nanocomposite would be of great use to the industry to check the quality of the products made and to ensure compliance with their specifications. Very few NDE techniques found in the literature can evaluate the level of dispersion of the nanoparticles in the whole nanocomposite. Here, a recently developed NDE technique based on pulsed phase thermography (PPT) in transmission mode was used to assess the particle dispersion in ultra-low, less than 0.

Analysis of the Parameters Affecting the Stiffness of Short Sisal Fiber Biocomposites Manufactured by Compression-Molding.

The use of natural fiber-based composites is on the rise in many industries. Thanks to their eco-sustainability, these innovative materials make it possible to adapt the production of components, systems and machines to the increasingly stringent regulations on environmental protection, while at the same time reducing production costs, weight and operating costs. Optimizing the mechanical properties of biocomposites is an important goal of applied research.

Fluoroless Catheter Ablation of Atrial Fibrillation: Integration of Intracardiac Echocardiography and Cartosound Module.

Objective: To evaluate the feasibility, safety, and clinical efficacy of non-fluoroscopic radiofrequency catheter ablation of atrial fibrillation (AF) in comparison to traditional fluoroscopy-guided ablation in a local Canadian community cohort.

Methods: We retrospectively studied consecutive patients with paroxysmal and persistent AF undergoing pulmonary vein isolation (PVI) guided by intracardiac echocardiography (ICE) and Carto system (CartoSound module). ICE-guided PVI without fluoroscopy (Zero-fluoro group) was performed in 116 patients, and conventional fluoroscopy-guided PVI (Traditional group) was performed in 131 patients.

Instructor facilitation mediates students' negative perceptions of active learning instruction.

Studies have demonstrated students' resistance to active learning, despite evidence illustrating that their learning is improved relative to students in lectures. Specifically, while active learning and group work are effective at engaging students in their learning process, studies report that students' perceptions of active learning approaches are not always positive. What remains underexplored is whether students' perceptions of active learning improve with effective instructor facilitation and whether there exists differential perceptions between racially minoritized students and represented students.

Safety and feasibility of left bundle branch area pacing following valvular interventions: Multicenter study.

Objectives: To evaluate the safety and feasibility of left bundle branch area pacing (LBBAP) in patients with valvular interventions.

Methods: Eighty-four patients were included in this study. All patients underwent recent surgical or percutaneous valvular interventions.

Culturally Responsive Practices: Insights from a High-Quality Math Afterschool Program Serving Underprivileged Latinx Youth.

High-quality afterschool programs (ASPs) are opportunities to diversify the ways that Latinx youth from economically underprivileged communities experience STEM learning. Utilizing qualitative methods, based on the experiences and perspectives of low-income Latinx middle school participants of a math enrichment ASP in Southern California, we identified four culturally responsive practices: (1) the promotion of an inclusive, safe, and respectful program climate, (2) engaging in personal conversations, (3) facilitating opportunities for mutual and math learning across diverse cultures and perspectives, and (4) the promotion of math and a range of social-emotional skills across contexts. These practices helped youth feel more connected to the program, their peers, and program staff (college mentors); provided a platform for youth voice and contribution to the processes of teaching and learning; facilitated opportunities for skill development and practice across the different contexts of youth's lives; interrelated with Latinx cultural values; and helped to promote youth's engagement and math learning.

New Concept in Bioderived Composites: Biochar as Toughening Agent for Improving Performances and Durability of Agave-Based Epoxy Biocomposites.

Biocomposites are increasingly used in the industry for the replacement of synthetic materials, thanks to their good mechanical properties, being lightweight, and having low cost. Unfortunately, in several potential fields of structural application their static strength and fatigue life are not high enough. For this reason, several chemical treatments on the fibers have been proposed in literature, although still without fully satisfactory results.

Initial Experience, Safety, and Feasibility of Left Bundle Branch Area Pacing: A Multicenter Prospective Study.

Objectives: This study sought to evaluate the safety and feasibility of conduction system pacing by performing left bundle branch area pacing (LBBAP).

Background: There are limited data from single centers showing that LBBAP may circumvent the technical and electrophysiological challenges encountered with His bundle pacing.

Methods: Patients referred for pacemaker implantation at 2 centers between February 1, 2019, and March 31, 2020, were considered for LBBAP.

Carbon Nanotubes Dispersion Assessment in Nanocomposites by Means of a Pulsed Thermographic Approach.

The extensive production of polymer composites reinforced by carbon nanotube is limited by the absence of non-destructive evaluation (NDE) methods capable of assessing product quality to guarantee compliance with specifications. It is well known that the level of dispersion of carbon nanotubes (CNTs) in the polymer matrix is the parameter that, much more than others, can influence their enhancement capabilities. Here an active Infrared Thermography Non Destructive Testing(IR-NDT) inspection, joined with pulsed phase thermography (PPT), were applied for the first time to epoxy-CNT composites to evaluate the level of dispersion of the nanoparticles.

Clinical importance of late gadolinium enhancement at right ventricular insertion points in otherwise normal hearts.

Late gadolinium enhancement (LGE) has an established prognostic value in otherwise normal hearts, when detected with a subepicardial or intramyocardial pattern; nevertheless, the clinical relevance of isolated right ventricular insertion point (RVIP) LGE is yet to be defined. From a retrospectively identified cohort of 2000 consecutive patients undergoing CMR, we selected 420 patients according to study's inclusion and exclusion criteria (270 males, mean age 38 ± 17 years) with apparently normal hearts: besides 36 patients with non-ischemic pattern LGE (other-LGE group), we found isolated RVIP-LGE in 44 patients and absence of LGE (no-LGE group) in 340 patients. Clinical follow-up was performed for a median of approximately 6 years.

Use of sacubitril/valsartan in Marfan syndrome-related cardiomyopathy: The first case report.

Rationale: Marfan syndrome is a rare cause of heart failure due to primary or secondary cardiomyopathy. Recently, sacubitril/valsartan-an angiotensin receptor blocker-neprilysin inhibitor-has been added in clinical practice as a standard therapy for heart failure. To our knowledge, there are no data on sacubitril/valsartan's effects on cardiovascular outcomes in patients with Marfan syndrome.

Risk factors for fragility fractures in type 1 diabetes.

Objective: To determine clinical diabetes-related risk factors for fragility fractures in type 1 diabetes (T1D).

Research Design And Methods: History of bone fragility fractures occurring after T1D diagnosis was assessed by questionnaire in this cross-sectional study in 600 T1D subjects. Glycated hemoglobin A1c (HbA1c) over the previous 5 years was used as an index of long-term glycemic control; complications were adjudicated by physician assessment.

Influenza B virus infection complicated by life-threatening pericarditis: a unique case-report and literature review.

Background: Acute pericarditis may occur frequently after viral infections. To our knowledge, influenza B virus infection complicated by pericarditis without myocardial involvement has never been reported. We report the first case of life-threatening pericarditis caused by influenza B virus infection.

Prognostic Role of Cardiac Magnetic Resonance in Arrhythmogenic Right Ventricular Cardiomyopathy.

We sought to evaluate the prognostic role of cardiac magnetic resonance (CMR) in patients with definite, borderline and possible diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) as defined by the International Task Force (TF) in 2010. CMR was performed in 175 patients: 52 with definite, 50 with borderline and 73 possible ARVC. Abnormal-CMR was defined as the presence of ≥1 CMR abnormalities (including abnormalities of right ventricular and left ventricular wall motion, fat infiltration, late gadolinium enhancement, dilation and dysfunction of either ventricles).