Asymmetric Schottky Barrier-Generated MoS/WTe FET Biosensor Based on a Rectified Signal.

Field-effect transistor (FET) biosensors can be used to measure the charge information carried by biomolecules. However, insurmountable hysteresis in the long-term and large-range transfer characteristic curve exists and affects the measurements. Noise signal, caused by the interference coefficient of external factors, may destroy the quantitative analysis of trace targets in complex biological systems.

L-histidine functionalized ZiF-8 with aggregation-induced emission for detection of tetracycline.

In this study, we constructed zinc based metal-organic framework functionalized by L-histidine (His@ZiF-8). The His@ZiF-8 had high porosity, large surface area, abundant carboxyl and amino group, which has been found to greatly enhance the aggregation-induced emission (AIE) of tetracycline (TC). After the His@ZiF-8 enrichment with TC, the TC exhibited strong fluorescence emission peak at 565 nm based on AIE.

Silver nanoparticles combined with amino-functionalized UiO-66 for sensitive detection of glutathione.

Herein, a fluorescent nanosensor has been constructed for detection of glutathione (GSH) based on NH-UiO-66 and AgNPs. The NH-UiO-66 was synthesized where 2-amino-terephthalic acid as the organic ligand and Zr as the center metal ions. The AgNPs can enhance the fluorescence of NH-UiO-66 based on metal enhanced fluorescence (MEF) effect.

Boric-acid-modified FeO@PDA@UiO-66 for enrichment and detection of glucose by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Herein, boric-acid-modified multifunctional Zr-based metal-organic frameworks (denoted as FeO@PDA@B-UiO-66) were synthesized by hydrothermal reaction and surface modification. Compared to traditional matrix, FeO@PDA@B-UiO-66 has the advantages of high ionization efficiency, high surface area, low matrix background, porous structure, and numerous boric-acid-active sites. By combining matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), FeO@PDA@B-UiO-66 was used as an adsorbent and matrix for enrichment and detection of glucose, based on a specific reaction between boric acid and glucose.

Synthesis of magnetic core-shell FeO@PDA@Cu-MOFs composites for enrichment of microcystin-LR by MALDI-TOF MS analysis.

Microcystin-LR (MC-LR) is a toxin released from cyanobacteria in eutrophicated water. MC-LR is the most abundant and the most toxic among microcystins. In this work, core-shell structured copper-based magnetic metal-organic framework (FeO@PDA@Cu-MOFs) composites were synthesized a solvothermal reaction and a sol-gel method.