Publications by authors named "Panossian V"

Purpose: This study aims to identify predictors of discharge to post-acute care in geriatric emergency general surgery (EGS) patients.

Methods: This is a retrospective study of geriatric emergency general surgery (EGS) patients at a tertiary care facility between 2017 and 2018. Inclusion criteria were ≥ 65 years old and presented directly from home.

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Background: Previous studies have shown that patients with rib fractures experience long-term functional limitations. However, the specific predictors of these worse long-term functional limitations remain under-characterized.

Methods: We conducted a prospective cohort study including patients ≥18 years with an injury severity score ≥9 and isolated chest injury.

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Background: The impact of tracheostomy timing on outcomes is unclear in geriatric patients with traumatic brain injury (TBI).

Methods: Patients aged≥65 with isolated severe TBI who underwent tracheostomy were identified in the ACS-TQIP 2017-2020 database. Patients were grouped by early (<10 days) vs.

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Background: The POTTER calculator, a widely used interpretable artificial intelligence (AI) risk calculator, has been validated in population-based studies and shown to predict outcomes in emergency general surgery (EGS) patients better than surgeons. We sought to prospectively validate POTTER.

Study Design: Patients undergoing an emergency exploratory laparotomy for non-trauma indications at two Academic Medical Centers between June 2020 and March 2022 were included.

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Background: Patients with severe traumatic brain injury (TBI) are at an increased risk of respiratory failure refractory to traditional therapies. The safety of extracorporeal membrane oxygenation (ECMO) in this population remains unclear. We aimed to examine outcomes following ECMO compared with traditional management in severe TBI patients.

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Article Synopsis
  • Renal angioembolization (RAE) is effective for low-grade renal injuries and may improve outcomes in high-grade renal trauma (HGRT), compared to traditional surgery.
  • A study using data from 591 patients with HGRT found that RAE did not significantly change morbidity or length of hospital stays but was linked to lower mortality rates compared to surgery.
  • The findings suggest that RAE might help preserve kidney function and enhance non-operative treatment efficacy, but further randomized studies are necessary to confirm these results.
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Background: The aim of this study is to quantify the relative contribution of comorbidities and pre-operative functional status on outcomes in geriatric emergency general surgery (EGS) patients.

Methods: This is a retrospective study of older-adult EGS patients at an academic medical center between 2017 and 2018. Patients ≥65 years were included.

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Introduction: Racial and ethnic disparities in emergency general surgery (EGS) patients have been well described in the literature. Nonetheless, the burden of these disparities, specifically within the more vulnerable older adult population, is relatively unknown. This study aims to investigate racial and ethnic disparities in clinical outcomes among older adult patients undergoing EGS.

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Purpose: Our understanding of the growing geriatric population's risk factors for outcomes after traumatic injury remains incomplete. This study aims to compare outcomes of severe isolated blunt chest trauma between young and geriatric patients and assess predictors of mortality.

Methods: The ACS-TQIP 2017-2020 database was used to identify patients with severe isolated blunt chest trauma.

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  • * Researchers analyzed data from 580 patients, finding that 25.2% were considered frail; a comparison showed frail patients experienced greater functional limitations in daily activities than their non-frail counterparts (69.6% vs. 47.2%).
  • * The findings suggest that frail elderly patients with severe injuries would benefit from screening and ongoing support after hospital discharge to improve their long-term recovery and quality of life.
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  • Emergent surgical conditions in older patients often require major procedures, making it essential to assess risk factors for better decision-making and care planning.
  • A study analyzing data from thousands of patients aged 65 and older found that 13.6% died within 30 days post-surgery, with ASA status 5, septic shock, and dialysis being significant predictors of mortality.
  • The findings highlight that older patients with these risk factors face extremely high mortality rates after surgery, underscoring the importance of evaluating surgical futility in this vulnerable group.
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Background: While existing literature reports adverse effects of chronic steroid use on surgical wound outcomes, there remains lack of data exploring the effect of steroids on postoperative outcomes following lower extremity arterial bypass surgery. This study aims to explore the effect of chronic steroid use on surgical outcomes in patients undergoing open revascularization for lower extremity arterial occlusive disease.

Methods: Using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) files between 2005 and 2020, all patients receiving aortoiliac or infrainguinal arterial bypass for peripheral arterial disease (PAD) were identified by Current Procedural Terminology (CPT) codes.

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  • Obesity is a growing issue, particularly in emergency general surgery (EGS), where its effects on postoperative outcomes and decision-making are not fully understood.
  • Analyzed data from nearly 79,000 EGS patients revealed that higher obesity classes, especially class III, increased risks for postoperative complications, prolonged surgeries, and longer hospital stays.
  • The study indicates a clear link between obesity class and various surgical outcomes, highlighting the need for further research on how BMI influences surgical strategies and costs.
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  • Delayed fascial closure (DFC) is a technique used in emergency general surgery, but its benefits are not well established, prompting a comparison with immediate fascial closure (IFC) for patients with intra-abdominal contamination.
  • A study using data from the American College of Surgeons analyzed outcomes of 36,974 patients undergoing exploratory laparotomy, revealing that DFC leads to higher mortality rates and complications, including pneumonia and longer hospital stays.
  • The findings suggest that while DFC is common, it may lead to worse clinical outcomes and does not reduce complications, indicating a need for more research to clarify when DFC should be used in practice.*
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Background: Emergency general surgery performed among patients over 65 years of age represents a particularly high-risk population. Although interhospital transfer has been linked to higher mortality in emergency general surgery patients, its impact on outcomes in the geriatric population remains uncertain. We aimed to establish the effect of interhospital transfer on postoperative outcomes in geriatric emergency general surgery patients.

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Introduction: General surgery procedures place stress on geriatric patients, and postdischarge care options should be evaluated. We compared the association of discharge to a skilled nursing facility (SNF) versus home on patient readmission.

Methods: We retrospectively reviewed the Nationwide Readmission Database (2016-2019) and included patients ≥65 y who underwent a general surgery procedure between January and September.

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Purpose: For polytrauma patients with bilateral femoral shaft fractures (BFSF), there is currently no consensus on the optimal timing of surgery. This study assesses the impact of early (≤ 24 h) versus delayed (>24 h) definitive fixation on clinical outcomes, especially focusing on concomitant versus staged repair. We hypothesized that early definitive fixation leads to lower mortality and morbidity rates.

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  • Noncompressible truncal hemorrhage is a significant cause of preventable deaths outside of hospital settings, necessitating reliable animal models to test new treatments.
  • This study created a lethal injury model using Yorkshire swine, combining severe liver damage with controlled blood volume loss, resulting in rapid and consistent outcomes.
  • The developed model consistently led to high mortality rates within a short timeframe, making it a valuable tool for evaluating interventions for severe abdominal bleeding.
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Background: Current guidelines for sigmoid volvulus recommend endoscopy as a first line of treatment for decompression, followed by colectomy as early as possible. Timing of the latter varies greatly. This study compared early (≤2 days) versus delayed (>2 days) sigmoid colectomy.

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Background: The feasibility of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in initially node-positive patients is still controversial. We aim to evaluate the oncologic outcomes of SLNB after NACT and further compare the results between those who were initially node-negative and node-positive.

Methods: This is a retrospective cohort that included patients diagnosed with invasive breast cancer and had surgical management between January 2010 and December 2016.

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Background: Thoracic Endovascular Aortic Repair (TEVAR) is a minimally invasive surgery for repairing thoracic aneurysms and dissections. This study aims to compare postoperative outcomes of TEVAR performed under general versus locoregional anesthesia.

Methods: Utilizing the 2008-2019 American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database, patients older than the age of 18 years who received TEVAR, were identified using the following current procedural terminology codes: 33,880, 33,881, 33,883, 33,884, or 33,886.

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Background: Mid-regional proadrenomedullin (MR-proADM) is a biomarker released following endothelial damage. Studies have shown a correlation in predicting coronavirus disease 2019 (COVID-19) outcomes with MR-proADM levels. Our study aimed to investigate baseline MR-proADM as a predictor of a wider range of clinical outcomes of varying severity in patients admitted with COVID-19, and to compare to other biomarkers.

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Introduction: Procalcitonin (PCT) is a biomarker with established performance in the differentiation between bacterial and viral infections, predominantly in pulmonary infections, as well as the diagnosis and prognosis of bacterial sepsis. However, the role of PCT in extra-pulmonary infections is not well described.

Areas Covered: We reviewed the role of PCT in commonly experienced extra-pulmonary infections including meningitis, diabetic foot infection, prosthetic joint infection, osteomyelitis, and skin and soft tissue infection.

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Purpose: Coronavirus disease-2019 (COVID-19) is associated with a wide spectrum of clinical symptoms including acute respiratory failure. Biomarkers that can predict outcomes in patients with COVID-19 can assist with patient management. The aim of this study is to evaluate whether procalcitonin (PCT) can predict clinical outcome and bacterial superinfection in patients infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

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Background: Most studies on emergency resuscitative thoracotomy (ERT) suffer from either small sample size or unclear inclusion criteria. We sought to assess ERT outcomes and predictors of futility using a nationwide database.

Methods: Using a novel and comprehensive algorithm of combinations of specific International Classification of Diseases, Ninth Revision and International Classification of Diseases, Tenth Revision procedure codes denoting the multiple steps of an ERT (e.

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