Highly loaded nanoparticulate formulation of progesterone for emergency traumatic brain injury treatment.

Background: Progesterone (PG), a promising therapeutic for treating traumatic brain injury, has been difficult to formulate into a high-dose/low-volume form for emergency intravenous administration due to its hydrophobicity and crystallinity.

Results: This work demonstrates the use of Flash NanoPrecipitation to produce 300-nm PG-loaded polymeric nanoparticles with approximately 24 wt% drug loading using only components that are classified by the US FDA as generally recognized as safe. Approximately 80% of the encapsulated PG is in dissolved, rather than crystalline form.

Spontaneous assembly of a polymeric helicate of sodium with LVO(2) units forming the strand: photoinduced transformation into a mixed-valence product.

The anionic cis-dioxovanadium(V) complex species LVO(2)(-) of a tridentate ONS ligand (H(2)L) can bind sodium ion in a bis-monodentate fashion like a bridging carboxylate group. The product [LVO(2)Na(H(2)O)(2)](infinity) (1) is a water soluble polymeric compound in which the complementary units are held together by the simultaneous use of hydrogen bonding and Coulombic interactions. Crystallographic characterization reveals that 1 is a single stranded helicate with LVO(2)(-) units forming the strand which surrounds the labile sodium ions that occupy the positions on the axis.

Mixed-Oxidation Divanadium(IV,V) Compound with Ligand Asymmetry: Electronic and Molecular Structure in Solution and in the Solid State.

Reaction of [V(IV)OL(1)(Im)] (H(2)L(1) = S-methyl-3-((2-hydroxyphenyl)methyl)dithiocarbazate) with [V(V)OL(OCH(3))] allows isolation of (ImH)[L(1)OV-(&mgr;-O)-VOL] complexes 2 (H(2)L = H(2)L(2) = S-methyl-3-((5-bromo-2-hydroxyphenyl)methyl)dithiocarbazate) and 3 (H(2)L = H(2)L(1)), one of which (2) has ligand asymmetry not previously known in this type of complex. In the solid state, (ImH)[L(1)OV-(&mgr;-O)-VOL(2)] (2) provides an example of a divanadium(IV,V) compound with a syn angular [V(2)O(3)](3+) core structure that exhibits crystallographically imposed mirror symmetry due to static disorder. Crystals of 2 are orthorhombic, space group Pnma, with a = 10.