Temporal neural dynamics of understanding communicative intentions from speech prosody.

Understanding the correct intention of a speaker is critical for social interaction. Speech prosody is an important source for understanding speakers' intentions during verbal communication. However, the neural dynamics by which the human brain translates the prosodic cues into a mental representation of communicative intentions in real time remains unclear.

The modulating effect of musical expertise on lexical-semantic prediction in speech-in-noise comprehension: Evidence from an EEG study.

Musical expertise has been proposed to facilitate speech perception and comprehension in noisy environments. This study further examined the open question of whether musical expertise modulates high-level lexical-semantic prediction to aid online speech comprehension in noisy backgrounds. Musicians and nonmusicians listened to semantically strongly/weakly constraining sentences during EEG recording.

[Significance of BCL6, MYC, P53 genes abnormalities for the prognosis of diffuse large B-cell lymphoma].

Objective: To explore the influence of BCL6, MYC, P53 genes abnormalities can on the prognosis of diffuse large B-cell lymphoma (DLBCL), and to identify independent prognostic factors for DLBCL in order to facilitate clinical prognosis and selection of stratification treatment for the patients.

Methods: Sixty five newly diagnosed DLBCL pathological specimens were collected from 2009 to 2012. Interphase fluorescence in situ hybridization technique (I-FISH) was used to detect the status of BCL6, MYC and P53 genes.

[Comparison and analysis of SNV results: detected by transcriptome sequencing technology on initial diagnosis and remission stage of a patient with AML-M2].

This study was aimed to further clarify the pathogenesis of acute myeloid leukemia(AML), and to forecast new somatic mutations related with leukemia. The peripheral blood samples on initial diagnosis and remission stage of a patient with partial differentiated AML(AML-M2) were sequenced by high throughput transcriptome sequencing technology. The single nucleotide variation (SNV) which possibly related with pathogenesis of leukemia was screened through comparison of the expressed genes on initial diagnosis and after remission.

RNA-Seq analysis identifies aberrant RNA splicing of TRIP12 in acute myeloid leukemia patients at remission.

Aberrant splicing events play important roles in the pathogenesis of acute myeloid leukemia (AML). To investigate the aberrant splicing events in AML during treatment, we carried out RNA sequencing in peripheral mononuclear cell samples from a patient with complete remission. In addition to the sequencing samples, selected splicing events were confirmed and validated with real-time quantitative RT-PCR in another seven pairs of samples.