Publications by authors named "Pankaj Tyagi"

The field of drug discovery has long been challenged by the existence of "undruggable" proteins - targets that have resisted traditional small molecule approaches due to their structural or functional characteristics. This review explores the revolutionary potential of small interfering RNA (siRNA) technology in addressing these elusive targets, marking a paradigm shift in therapeutic development. We discuss the historical development of siRNA technology and its unique mechanism of action, which allows for the silencing of virtually any gene, including those coding for proteins previously deemed undruggable.

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Background: This bibliometric study examines the intersection of artificial intelligence (AI) and finance, providing a comprehensive analysis of its evolution, central themes, and avenues for further exploration. The study aims to uncover the theoretical foundations, methodological approaches, and practical implications of AI in financial contexts.

Methods: The research employs bibliometric techniques, using 607 Web of Science (WoS) indexed papers.

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CDK12 is essential for cellular processes like RNA processing, transcription, and cell cycle regulation, inhibiting cancer cell growth and facilitating macrophage invasion. CDK12 is a significant oncogenic factor in various cancers, including HER2-positive breast cancer, Anaplastic thyroid carcinoma, Hepatocellular carcinoma, prostate cancer, and Ewing sarcoma. It is also regarded as a potential biomarker, emphasizing its broader significance in oncology.

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Mild Cognitive Impairment (MCI) is swiftly emerging as a prevalent clinical concern within the elderly demographic. Willoughby spearheaded the pioneering investigation into the evolution of memory decline spanning from the age of 20 to 70. Employing a computerized substitution examination, he pinpointed a zenith in memory prowess at the age of 22, signifying the shift from infancy, succeeded by a gradual decline in later years in 1929.

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This research explores the eco-friendly synthesis of silver nanoparticles (AgNPs) using Cassia occidentalis L. seed extract. Various analytical techniques, including UV-visible spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy (EDX), were employed for comprehensive characterization.

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  • This study presents the creation of biogenic copper oxide nanoparticles (CuONPs) using leaf extracts through an eco-friendly method, with detailed characterization using various spectroscopy and microscopy techniques.
  • The synthesized CuONPs showed a peak at 272 nm in UV-VIS spectroscopy, confirmed their crystalline structure with XRD, and were predominantly spherical and small in size (15-25 nm) according to TEM analysis.
  • The CuONPs demonstrated significant antibacterial properties against multiple pathogens, with the highest effectiveness noted against one particular bacterium, and showed strong antioxidant activity at higher concentrations, indicating their potential use in combating harmful microorganisms and implications for ecotoxicology.
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  • The study tackles the complex relationship between molecular structure and odor perception, highlighting challenges due to vague odor descriptors.
  • Recent advancements in machine learning (ML), particularly with the XGBoost model, have enabled more accurate predictions of odors from molecular structures.
  • The developed model achieved over 99% precision and sensitivity in predicting seven basic smells, outperforming other recent models and offering insights into the structure-odor relationship.
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Castor ( L.) is an important nonedible industrial crop that produces oil, which is used in the production of medicines, lubricants, and other products. However, the quality and quantity of castor oil are critical factors that can be degraded by various insect pest attacks.

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Multi-target therapies have been considered one of the viable options to overcome the challenges to eradicate intrinsic and acquired drug-resistant cancer cells. While to increase the efficacy of therapeutics, the use of a single drug against multiple structurally similar sites, which noncommittedly modulate several vital cellular pathways proposed as a potential alternative to a 'single drug single target'. Besides, it reduces the usage of a number of drugs and their side effects.

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Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells.

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The present study utilized Aspergillus spp. for the synthesis of silver nanoparticles (AgNPs); the developed AgNPs were categorized using analytical techniques, that is, ultraviolet-visible (UV-vis) spectrophotometer, Zeta-potential, dynamic light scattering (DLS), and transmission electron microscopy (TEM). A sharp peak of 463 nm highlighted the synthesis of AgNPs; further Zeta-potential of -16 mV indicates stability of synthesized AgNPs.

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The indispensable role of Beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) in Amyloid beta (Aβ) plaques generation and Aβ-mediated synaptic dysfunctions makes it a crucial target for therapeutic intervention in Alzheimer's disease (AD). In order to find out the potential inhibitors of BACE1, the present study focused on five phytochemicals from Pueraria tuberosa, namely, daidzin, genistin, mangiferin, puerarin, and tuberosin. A molecular docking study showed that all five phytochemicals presented the strongest BACE1 inhibition.

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Olfaction transduction mechanism is triggered by the binding of odorants to the specific olfactory receptors (OR's) present in the nasal cavity. Different odorants stimulate different OR's due to the difference in shape, physical and chemical properties. In this paper, a deep neural network architecture DeepOlf, based on molecular features and fingerprints of odorants and ORs, to predict whether a chemical compound is a potential odorant or not along with its interacting OR is proposed.

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Article Synopsis
  • SARS-CoV-2 is the virus responsible for COVID-19, which spreads rapidly and has a high mortality rate, with limited current containment options.
  • Researchers identified three natural compounds—ursolic acid, carvacrol, and oleanolic acid—that may inhibit the virus's main protease using advanced molecular modeling techniques.
  • These compounds demonstrate strong binding stability to the M protein and meet safety criteria for potential therapeutic use against COVID-19.
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With the advancement of high throughput techniques, the discovery rate of enzyme sequences has increased significantly in the recent past. All of these raw sequences are required to be precisely mapped to their respective functional attributes, which helps in deciphering their biological role. In the recent past, various prediction models have been proposed to predict the enzyme functional class; however, all of these models were able to quantify at most six functional enzyme classes ( to ) out of existing seven functional classes, making these approaches inappropriate for handling enzymes corresponding to the seventh functional class ().

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The SPX gene family, ubiquitous in all vascular plants, plays a critical role in plant development and growth as well as in response to phosphorus stress. Based on genomic census, 46 TaSPX genes were identified in the wheat genome. All of them are evenly distributed on 13 of the 21 wheat chromosomes and chromosome 7A contains the largest members.

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  • Olfaction, or the sense of smell, is essential for detecting odors and social cues, though humans have a weaker sense compared to animals, it's highly precise in identifying millions of odorants.
  • The process begins when odorants bind to olfactory receptors, which translate these chemical signals into neuronal action-potentials, sending information to the brain's olfactory bulb for processing.
  • The article discusses the genetic basis of the olfactory system, including functional olfactory receptor genes, and explores the mechanisms, theories of odor perception, and current challenges in olfactory research.
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For nearly a decade, silver nanoparticles (AgNPs) have been the most prevalent commercial nanomaterials products widely used in different biomedical applications due to their broad-spectrum antimicrobial activity. However, their poor long-term stability in different environments, namely, pH, ionic strength, and temperature, and cytotoxicity toward mammalian cells has restricted their more extensive applications. Hence, there is urgent need to develop highly biocompatible, non-toxic, and stable silver nanoparticles for wide-ranging environments and applications.

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An extensive bioinformatics based study has been performed to gain insight into the structural and functional aspects of candidate genes involved in Nitrogen and Phosphorus nutrition in wheat. Based on our study, 37 N and P nutrition candidate genes were identified (24 NUE and 13 inorganic phosphate transporters) in wheat genome. 23 gene specific novel microsatellites were discovered using genomic sequences of identified N and P nutrition genes.

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Aim: To investigated clinical, endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.

Methods: Consecutive symptomatic patients undergoing colonoscopy, and diagnosed to have ulcerations in the ileocecal (I/C) region, were enrolled. Biopsy was obtained and their clinical presentation and outcome were recorded.

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  • Malnutrition is common in patients with cirrhosis, and traditional assessment methods like BMI and skin fold thickness have limitations.
  • A study involving 352 cirrhotic patients and 189 chronic hepatitis patients found that malnutrition affects 56% of cirrhotic and 24% of chronic hepatitis patients, with handgrip strength (HG) being the most effective indicator.
  • HG strength showed the highest diagnostic accuracy (87%) for malnutrition compared to mid arm muscle circumference (MAMC) and triceps skin fold thickness (TST), making it a reliable bedside tool for assessing nutritional status in these patients.
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Common bile duct (CBD) stones can lead to serious complications and require intervention with either endoscopic retrograde cholangiopancreatography (ERCP) or laparoscopic techniques for urgent relief. On an average 10%-20% of the patients with gall bladder stones can have associated CBD stones. CBD stones during pregnancy can be associated with hazardous complications for both the mother and the fetus.

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