One-Pot Synthesis of Dibenzo[,]oxepines and Total Synthesis of Bauhinoxepin C.

In this work, we report a novel and simple one-pot synthesis of substituted dibenzo[,]oxepines under transition-metal-free conditions. This cascade process involves nucleophilic aromatic substitution followed by Knoevanagel condensation, as evidenced by the isolated reaction intermediates. We have also achieved the synthesis of anticancer bauhinoxepin C in 7 steps with 5.