A highly lipophilic terpyridine ligand as an efficient fluorescent probe for the selective detection of zinc(II) ions under biological conditions.

The present work describes the synthesis of new terpyridine (tpy) molecules possessing functionalized long alkyl chains at the 4'-position associated with a planar structure with considerable delocalization. Out of the three synthesized tpy derivatives (L1, L2, and L3), L2 containing an ester group at the end of the alkyl chain emerged as an excellent probe for the selective detection of Zn. The detection of Zn ions under biological conditions was achieved by the introduction of a distinct aliphatic undecanoic ester chain at the 4'-position of the core terpyridine ring, thereby making it more lipophilic.

Promoting Apoptosis in MCF-7 Cells via ROS Generation by Quinolino-triazoles Derived from One-Pot Telescopic Synthesis.

Inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2) facilitates potent antiangiogenic and anticancer responses. In this regard, the development of effective pharmacophores, i.e.

Studies on synthesis and influence of sterically driven Ni(II)-terpyridine (NNN) complexes on BSA/DNA binding and anticancer activity.

The present work demonstrates the synthesis, structural diversity and coordination behavior of some selected new Ni(II)-Tpy complexes. The structural analysis revealed the coordination of the selected terpyridine ligands with the core metal atom in two different modes via dimeric species (1:1 fashion) through the Cl-bridging and a bis(Tpy)-Ni complex (2:1 fashion). Perhaps the most striking manifestations of these Ni(II)-Tpy complexes are BSA/DNA binding ability and anticancer activity.

A Comparative Study of Acute Invasive Fungal Sinusitis During the First and Second Waves of the COVID-19 Pandemic.

We aimed to compare the demography, clinical profile, histopathology, fungal culture, radiology, surgery performed, medical therapy and outcomes of patients with acute invasive fungal sinusitis seen during the first and second waves of the COVID-19 pandemic by retrospectively reviewing their case records. Of 238 patients, 43(18.1%) presented during the first wave and 195(81.

Comparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study.

In the aftermath of the COVID-19 pandemic, the evolution of the SARS-CoV-2 into a seasonal pathogen along with the emergence of new variants, underscores the need for dynamic and adaptable responses, emphasizing the importance of sustained vaccination strategies. This observer-blind, double-dummy, randomized immunobridging phase 2 study (NCT05175742) aimed to compare the immunogenicity induced by two doses of 40 μg PTX-COVID19-B vaccine candidate administered 28 days apart, with the response induced by two doses of 30 µg Pfizer-BioNTech COVID-19 vaccine (BNT162b2), administered 21 days apart, in Nucleocapsid-protein seronegative adults 18-64 years of age. Both vaccines were administrated via intramuscular injection in the deltoid muscle.

Estimating the potential impact of a health tax on the demand for unhealthy food and beverages and on tax revenue in India.

Foods high in fat, sugar or salt are important contributors to the rising burden of non-communicable diseases globally and in India. Health taxes (HTs) have been used by over 70 countries as an effective tool for reducing consumption of sugar sweetened beverages (SSBs). However, the potential impacts of HTs on consumption and on revenues have not been estimated in India.

Threshold and suprathreshold component analysis in olfactory dysfunction: a retrospective study.

Objective: To analyse variations in the n-butanol threshold and odour identification scores of the Connecticut Chemosensory Clinical Research Centre test in various grades of olfactory dysfunction and in different nasal conditions leading to olfactory loss.

Method: Retrospective observational study.

Results: All grades of olfactory dysfunction were predominantly noted among males.

"Wearables on vogue": a scoping review on wearables on physical activity and sedentary behavior during COVID-19 pandemic.

Background: Wearables are intriguing way to promote physical activity and reduce sedentary behavior in populations with and without chronic diseases. However, the contemporary evidence demonstrating the effectiveness of wearables on physical health during the COVID-19 pandemic has yet to be explored.

Aim: The present review aims to provide the readers with a broader knowledge of the impact of wearables on physical health during the pandemic.

Multistage Pruning of CNN Based ECG Classifiers for Edge Devices.

Using smart wearable devices to monitor patients' electrocardiogram (ECG) for real-time detection of arrhythmias can significantly improve healthcare outcomes. Convolutional neural network (CNN) based deep learning has been used successfully to detect anomalous beats in ECG. However, the computational complexity of existing CNN models prohibits them from being implemented in low-powered edge devices.

Cosmetic surgical procedures on the vulva and vagina - an overview.

Cosmetic surgery is defined as any procedure involving a change in the appearance or aesthetics of a normal anatomy where there are no congenital or acquired pathologies. The procedures that can be included under female cosmetic genital surgery are the following: reduction labiaplasty, vaginoplasty, hymenoplasty, "G-Spot amplification", and miscellaneous. Those who support these procedures could argue that women undergo such procedures as a matter of choice, whereas those opposed could argue that this choice is made because of society's fascination with physical appearance and feeling young.

Cavitary Coccidioidomycosis: Impact of azole antifungal therapy.

Unlabelled: Approximately 5 to 15% of patients with pulmonary coccidioidomycosis subsequently develop pulmonary cavities. These cavities may resolve spontaneously over a number of years; however, some cavities never close, and a small proportion causes complications such as hemorrhage, pneumothorax or empyema. The impact of azole antifungal treatment on coccidioidal cavities has not been studied.

Unusual complications of bone wax at the skull base.

Objective: This study aimed to describe the clinical presentation, microbiological profile and management of complications of bone wax usage for surgical procedures at the skull base.

Method: The case records of a series of five patients who developed post-operative surgical site complications because of bone wax usage during skull base surgery were reviewed.

Results: In all five patients, persistent site-specific clinical features were noted along with intra-operative presence of excessive bone wax.

Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.

Deregulation of protein kinase activity has been linked to many diseases ranging from cancer to AIDS and neurodegenerative diseases. Not surprisingly, drugging the human kinome - the complete set of kinases encoded by the human genome - has been one of the major drug discovery pipelines. Majority of the approved clinical kinase inhibitors target the ATP binding site of kinases.

Sterically controlled C-H/C-H homocoupling of arenes via C-H borylation.

A mild one-pot protocol for the synthesis of symmetrical biaryls by sequential Ir-catalyzed C-H borylation and Cu-catalyzed homocoupling of arenes is described. The regiochemistry of the biaryl formed is sterically controlled as dictated by the C-H borylation step. The methodology is also successfully extended to heteroarenes.

Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?

Background: Aurora A (AurA) kinase is a key mitotic protein implicated in cancer. Several small molecule inhibitors targeting the ATP binding site of this enzyme are in various stages of clinical development. However, these inhibitors can result in selectivity and drug resistance problems.

A Review of Automatic Methods Based on Image Processing Techniques for Tuberculosis Detection from Microscopic Sputum Smear Images.

Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It primarily affects the lungs, but it can also affect other parts of the body. TB remains one of the leading causes of death in developing countries, and its recent resurgences in both developed and developing countries warrant global attention.

Developing sustainable global health technologies: insight from an initiative to address neonatal hypothermia.

Relative to drugs, diagnostics, and vaccines, efforts to develop other global health technologies, such as medical devices, are limited and often focus on the short-term goal of prototype development instead of the long-term goal of a sustainable business model. To develop a medical device to address neonatal hypothermia for use in resource-limited settings, we turned to principles of design theory: (1) define the problem with consideration of appropriate integration into relevant health policies, (2) identify the users of the technology and the scenarios in which the technology would be used, and (3) use a highly iterative product design and development process that incorporates the perspective of the user of the technology at the outset and addresses scalability. In contrast to our initial idea, to create a single device, the process guided us to create two separate devices, both strikingly different from current solutions.

Investment case for improving maternal and child health: results from four countries.

Background: Without addressing the constraints specific to disadvantaged populations, national health policies such as universal health coverage risk increasing equity gaps. Health system constraints often have the greatest impact on disadvantaged populations, resulting in poor access to quality health services among vulnerable groups.

Methods: The Investment Cases in Indonesia, Nepal, Philippines, and the state of Orissa in India were implemented to support evidence-based sub-national planning and budgeting for equitable scale-up of quality MNCH services.

Fragment-based ligand design of novel potent inhibitors of tankyrases.

Tankyrases constitute potential drug targets for cancer and myelin-degrading diseases. We have applied a structure- and biophysics-driven fragment-based ligand design strategy to discover a novel family of potent inhibitors for human tankyrases. Biophysical screening based on a thermal shift assay identified highly efficient fragments binding in the nicotinamide-binding site, a local hot spot for fragment binding.

An asynchronous P300 BCI with SSVEP-based control state detection.

In this paper, an asynchronous brain-computer interface (BCI) system combining the P300 and steady-state visually evoked potentials (SSVEPs) paradigms is proposed. The information transfer is accomplished using P300 event-related potential paradigm and the control state (CS) detection is achieved using SSVEP, overlaid on the P300 base system. Offline and online experiments have been performed with ten subjects to validate the proposed system.

Prereferral rectal artesunate for treatment of severe childhood malaria: a cost-effectiveness analysis.

Background: Severely ill patients with malaria with vomiting, prostration, and altered consciousness cannot be treated orally and need injections. In rural areas, access to health facilities that provide parenteral antimalarial treatment is poor. Safe and effective treatment of most severe malaria cases is delayed or not achieved.

Adaptation in P300 brain-computer interfaces: a two-classifier cotraining approach.

A cotraining-based approach is introduced for constructing high-performance classifiers for P300-based brain-computer interfaces (BCIs), which were trained from very little data. It uses two classifiers: Fisher's linear discriminant analysis and Bayesian linear discriminant analysis progressively teaching each other to build a final classifier, which is robust and able to learn effectively from unlabeled data. Detailed analysis of the performance is carried out through extensive cross-validations, and it is shown that the proposed approach is able to build high-performance classifiers from just a few minutes of labeled data and by making efficient use of unlabeled data.